INT159312

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Context Info
Confidence 0.43
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 1.79
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Reln) extracellular space (Reln) extracellular region (Reln)
cell adhesion (Reln) proteinaceous extracellular matrix (Reln) molecular_function (Reln)
Anatomy Link Frequency
cortex 2
lateral 1
Reln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
GABAergic 9 100.00 Very High Very High Very High
Opioid 6 100.00 Very High Very High Very High
fluoxetine 3 97.96 Very High Very High Very High
Central grey 108 88.92 High High
depression 3 87.28 High High
Morphine 24 76.12 Quite High
parabrachial 9 55.16 Quite High
Endogenous opioid 3 49.44 Quite Low
Anterior cingulate 9 47.12 Quite Low
amygdala 15 34.20 Quite Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 114 88.92 High High
Depression 3 87.28 High High
Manic Depressive Disorder 3 86.40 High High
Schizophrenia 3 85.68 High High
Autism 3 85.08 High High
Cognitive Disorder 3 38.40 Quite Low
Disease 3 5.00 Very Low Very Low Very Low
Body Weight 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present results suggest that the Reelin signaling and GABAergic systems are affected by commonly used psychotropic medications.
Regulation (affected) of Reelin associated with gabaergic
1) Confidence 0.43 Published 2009 Journal Schizophr. Res. Section Abstract Doc Link 19359144 Disease Relevance 0.31 Pain Relevance 0.22
The current study investigated whether chronic administration of psychotropic medications (clozapine, fluoxetine, haloperidol, lithium, olanzapine, and valproic acid) used in the treatment of psychiatric disorders alters levels of Reelin, its receptor Vldlr, downstream molecules Gsk3 beta, Dab-1, and Gad65/67 in rat prefrontal cortex as measured by qRT-PCR and SDS-PAGE and western blotting. qRT-PCR revealed that mRNAs for Reelin, Vldlr, Dab-1, Gsk3 beta, and Gad65 were each significantly altered by at least one of the drugs tested, and in the case of Reelin, Dab-1, and Gsk3 beta, by multiple drugs.
Regulation (alters) of Reelin in cortex associated with fluoxetine
2) Confidence 0.26 Published 2009 Journal Schizophr. Res. Section Abstract Doc Link 19359144 Disease Relevance 0.42 Pain Relevance 0.18
The current study investigated whether chronic administration of psychotropic medications (clozapine, fluoxetine, haloperidol, lithium, olanzapine, and valproic acid) used in the treatment of psychiatric disorders alters levels of Reelin, its receptor Vldlr, downstream molecules Gsk3 beta, Dab-1, and Gad65/67 in rat prefrontal cortex as measured by qRT-PCR and SDS-PAGE and western blotting. qRT-PCR revealed that mRNAs for Reelin, Vldlr, Dab-1, Gsk3 beta, and Gad65 were each significantly altered by at least one of the drugs tested, and in the case of Reelin, Dab-1, and Gsk3 beta, by multiple drugs.
Regulation (altered) of Reelin in cortex associated with fluoxetine
3) Confidence 0.19 Published 2009 Journal Schizophr. Res. Section Abstract Doc Link 19359144 Disease Relevance 0.39 Pain Relevance 0.23
As commented in the Introduction, the rlPAG is an opioid sensitive site, which is
Regulation (sensitive) of rlPAG associated with opioid
4) Confidence 0.02 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2657915 Disease Relevance 0.23 Pain Relevance 0.21
present study, we performed a comprehensive investigation on the rlPAG afferent
Regulation (afferent) of rlPAG
5) Confidence 0.02 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2657915 Disease Relevance 0.45 Pain Relevance 0.53
We have presently shown that the rlPAG is also targeted by the lateral
Regulation (targeted) of rlPAG in lateral
6) Confidence 0.01 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2657915 Disease Relevance 0 Pain Relevance 0.03

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