INT159349

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Context Info
Confidence 0.03
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.61
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos1) enzyme binding (Nos1) cytoplasm (Nos1)
cytosol (Nos1) oxidoreductase activity (Nos1) plasma membrane (Nos1)
Anatomy Link Frequency
neuronal 2
Zfp956 (Mus musculus)
Nos1 (Mus musculus)
Pain Link Frequency Relevance Heat
Tetrahydrobiopterin 2 98.52 Very High Very High Very High
Potency 2 93.80 High High
Pain 4 78.88 Quite High
Eae 2 77.28 Quite High
Disease Link Frequency Relevance Heat
Endotoxemia 2 80.72 Quite High
Pain 2 78.88 Quite High
Nociception 2 75.84 Quite High
Disease 2 69.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mechanistic analysis suggests that KLYP956 binds the oxygenase domain in the vicinity of the active site heme and inhibits iNOS and neuronal NOS (nNOS) by preventing the formation of enzymatically active dimers.
KLYP956 Negative_regulation (inhibits) of nNOS in neuronal
1) Confidence 0.03 Published 2009 Journal Mol. Pharmacol. Section Abstract Doc Link 19364813 Disease Relevance 0.31 Pain Relevance 0.21
Mechanistic analysis suggests that KLYP956 binds the oxygenase domain in the vicinity of the active site heme and inhibits iNOS and neuronal NOS (nNOS) by preventing the formation of enzymatically active dimers.
KLYP956 Negative_regulation (inhibits) of neuronal NOS in neuronal
2) Confidence 0.01 Published 2009 Journal Mol. Pharmacol. Section Abstract Doc Link 19364813 Disease Relevance 0.30 Pain Relevance 0.21

General Comments

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