INT159360

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Context Info
Confidence 0.67
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 2.01
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SMG1) nucleus (SMG1) response to stress (SMG1)
cytoplasm (SMG1)
Anatomy Link Frequency
lip 2
neural 2
parietal cortex 1
anterior 1
SMG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Trigeminal neuralgia 9 99.76 Very High Very High Very High
anesthesia 4 82.48 Quite High
Pain 10 81.64 Quite High
imagery 14 73.56 Quite High
adenocard 8 58.00 Quite High
Somatosensory cortex 1 56.36 Quite High
fifth nerve 1 55.32 Quite High
Neuropathic pain 4 49.04 Quite Low
Multiple sclerosis 4 48.12 Quite Low
rheumatoid arthritis 4 45.96 Quite Low
Disease Link Frequency Relevance Heat
Headache 9 99.76 Very High Very High Very High
Adhesions 6 99.40 Very High Very High Very High
Cleft Palate 42 94.80 High High
Pain 9 81.64 Quite High
Thinness 3 74.68 Quite High
Anaemia 1 74.16 Quite High
Body Weight 2 66.84 Quite High
Cancer 16 50.44 Quite High
Neuropathic Pain 4 49.04 Quite Low
Demyelinating Disease 4 48.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For lip stimulation SI and SII activations were reduced in patients with TN on the contra- but not on the ipsilateral side to the stimulus.
Positive_regulation (activations) of lip in lip associated with trigeminal neuralgia
1) Confidence 0.67 Published 2009 Journal Hum Brain Mapp Section Abstract Doc Link 19365802 Disease Relevance 0.98 Pain Relevance 1.15
In the absence of exogenous LPC, WT-ATX produced its maximal response at the concentration of ATX used (0.23 ?
Positive_regulation (concentration) of ATX
2) Confidence 0.30 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2649126 Disease Relevance 0 Pain Relevance 0
The catalytic domain, as well as the C-terminal and N-terminal domains, are necessary for ATX's unique LPLD activity; and a point mutation within the catalytic domain of murine ATX (L211H equivalent to L214 in human ATX) enhanced the nucleotide PDE activity while decreasing the LPLD activity [18].
Positive_regulation (necessary) of ATX
3) Confidence 0.30 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2649126 Disease Relevance 0.05 Pain Relevance 0.06
Because of the low activity of H226Q-ATX toward the substrates FS-3 and pNpTMP, we increased the concentration of this mutant ATX to 12 times that of WT-ATX.
Positive_regulation (increased) of ATX
4) Confidence 0.30 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2649126 Disease Relevance 0 Pain Relevance 0
This conclusion is consistent with the microstimulation data of Hanks and colleagues [27], which suggests that artificial activation of LIP during the motion discrimination task influences the initial offset of the neural accumulators.
Positive_regulation (activation) of LIP in neural
5) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824817 Disease Relevance 0 Pain Relevance 0
Our simulations of the results from monkey A, however, nicely reproduce both the behavioral data (Fig. 11A) and the absolute reward effect (Fig. 11C), demonstrating that the two data sets are compatible with the notion of bounded accumulation in LIP.
Positive_regulation (accumulation) of LIP
6) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824817 Disease Relevance 0 Pain Relevance 0
In parietal cortex Sereno et al. [9] reported activation of LIP and to some degree in LOP which in all likelihood corresponds to CIP [22].
Positive_regulation (activation) of LIP in parietal cortex
7) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789404 Disease Relevance 0 Pain Relevance 0
This analysis yielded a more restricted activation pattern compared to Figure 2, but nearly all activation sites left were located in the parietal cortex, including a bilateral activation of CIP, AIP and anterior LIP (Figure 7, yellow voxels).
Positive_regulation (activation) of LIP in anterior
8) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789404 Disease Relevance 0 Pain Relevance 0
More generally, however, we agree with Dorris and Glimcher and with Sugrue et al. that relative value is easily calculated from neural activity in LIP; it simply requires a comparison of activity at the two locations in LIP representing the choice targets (see below).
Positive_regulation (requires) of LIP in neural
9) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824817 Disease Relevance 0 Pain Relevance 0
Most of the Indian surgeons probably the that lip adhesion does not improve the overall result of lip repair.
Positive_regulation (result) of lip in lip associated with adhesions
10) Confidence 0.17 Published 2010 Journal Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India Section Body Doc Link PMC2938628 Disease Relevance 0.97 Pain Relevance 0.08
In the absence of exogenous LPC, WT-ATX produced its maximal response at the concentration of ATX used (0.23 ?
Positive_regulation (absence) of WT-ATX
11) Confidence 0.13 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2649126 Disease Relevance 0 Pain Relevance 0

General Comments

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