INT159409

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Context Info
Confidence 0.54
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 11
Disease Relevance 6.14
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PLAA)
Anatomy Link Frequency
skeletal muscle 3
muscle 1
optic 1
PLAA (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 7 100.00 Very High Very High Very High
peripheral neuropathy 80 95.72 Very High Very High Very High
Multiple sclerosis 100 90.80 High High
Inflammation 20 75.20 Quite High
Electroencephalography 10 41.92 Quite Low
Migraine 40 21.52 Low Low
headache 30 11.24 Low Low
Spinal cord 10 5.00 Very Low Very Low Very Low
adenocard 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 60 100.00 Very High Very High Very High
Optic Atrophy 150 99.50 Very High Very High Very High
Disease 200 98.96 Very High Very High Very High
Ataxia 110 96.04 Very High Very High Very High
Peripheral Neuropathy 80 95.72 Very High Very High Very High
Muscle Disease 90 93.36 High High
Spastic Paraparesis 40 92.88 High High
Sensorineural Hearing Loss 10 91.72 High High
Demyelinating Disease 120 90.80 High High
Chronic Progressive External Ophthalmoplegia 110 90.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further analyses on the features extracted by our technique indicated that information related to DOA is mostly distributed across frequency bands and that the presence of high frequencies (> 80 Hz), which reflect mostly muscle activity, is beneficial for DOA detection.
Gene_expression (detection) of DOA in muscle associated with anesthesia
1) Confidence 0.54 Published 2009 Journal Comput Methods Programs Biomed Section Abstract Doc Link 19371961 Disease Relevance 0 Pain Relevance 0.56
Expanding DOA+ phenotype
Gene_expression (phenotype) of DOA
2) Confidence 0.24 Published 2010 Journal Brain Section Body Doc Link PMC2842512 Disease Relevance 1.07 Pain Relevance 0.13
Excluding singleton cases and subjects younger than 25-years-old, it is also remarkable that in about a third of all pedigrees (11/32, 34.4%), family members were found to manifest both pure DOA and DOA+ phenotypes despite carrying the same OPA1 mutation, and presumably having shared common environmental influences, especially in the first two decades of life in parent-offspring cases.
Gene_expression (phenotypes) of DOA
3) Confidence 0.24 Published 2010 Journal Brain Section Body Doc Link PMC2842512 Disease Relevance 1.07 Pain Relevance 0.04
Figure 4Mean level of COX-deficiency in skeletal muscle biopsies: (A) pure DOA versus DOA+ phenotypes (P = 0.0226) and (B) pure DOA versus age-matched controls (P < 0.0001).
Gene_expression (phenotypes) of DOA in skeletal muscle
4) Confidence 0.24 Published 2010 Journal Brain Section Body Doc Link PMC2842512 Disease Relevance 0.11 Pain Relevance 0
Figure 4Mean level of COX-deficiency in skeletal muscle biopsies: (A) pure DOA versus DOA+ phenotypes (P = 0.0226) and (B) pure DOA versus age-matched controls (P < 0.0001).
Gene_expression (phenotypes) of DOA in skeletal muscle
5) Confidence 0.24 Published 2010 Journal Brain Section Body Doc Link PMC2842512 Disease Relevance 0.11 Pain Relevance 0
Figure 4Mean level of COX-deficiency in skeletal muscle biopsies: (A) pure DOA versus DOA+ phenotypes (P = 0.0226) and (B) pure DOA versus age-matched controls (P < 0.0001).
Gene_expression (phenotypes) of DOA in skeletal muscle
6) Confidence 0.24 Published 2010 Journal Brain Section Body Doc Link PMC2842512 Disease Relevance 0.11 Pain Relevance 0
Excluding singleton cases and subjects younger than 25-years-old, it is also remarkable that in about a third of all pedigrees (11/32, 34.4%), family members were found to manifest both pure DOA and DOA+ phenotypes despite carrying the same OPA1 mutation, and presumably having shared common environmental influences, especially in the first two decades of life in parent-offspring cases.
Gene_expression (phenotypes) of DOA
7) Confidence 0.24 Published 2010 Journal Brain Section Body Doc Link PMC2842512 Disease Relevance 1.07 Pain Relevance 0.04
Unlike this previously published family who only exhibited isolated optic atrophy, both DE-1 and NO-1 had DOA + features, with the two Norwegian siblings having a particularly aggressive disease course characterized by ataxia, peripheral neuropathy, corticospinal tract involvement and myopathy, in contrast to relatively mild sensorineural hearing loss for the two German siblings.
Gene_expression (features) of DOA in optic associated with ataxia, muscle disease, sensorineural hearing loss, peripheral neuropathy, disease and optic atrophy
8) Confidence 0.24 Published 2010 Journal Brain Section Body Doc Link PMC2842512 Disease Relevance 1.05 Pain Relevance 0.05
Mitochondrial mechanisms in DOA+
Gene_expression (mechanisms) of DOA
9) Confidence 0.24 Published 2010 Journal Brain Section Body Doc Link PMC2842512 Disease Relevance 0.17 Pain Relevance 0
In addition, we conducted a systematic review of the literature to identify other DOA+ families with confirmed OPA1 mutations.
Gene_expression (families) of DOA
10) Confidence 0.24 Published 2010 Journal Brain Section Body Doc Link PMC2842512 Disease Relevance 0.39 Pain Relevance 0.03
Figure 7Evolution of the major clinical features observed in DOA+ syndromes.


Gene_expression (syndromes) of DOA associated with syndrome
11) Confidence 0.24 Published 2010 Journal Brain Section Body Doc Link PMC2842512 Disease Relevance 0.97 Pain Relevance 0.04

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