INT159425

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Context Info
Confidence 0.67
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 9.35
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Cd320) molecular_function (Cd320) biological_process (Cd320)
Anatomy Link Frequency
plasma 1
liver 1
fat 1
Cd320 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 57 95.00 High High
anesthesia 12 67.40 Quite High
agonist 26 44.88 Quite Low
tolerance 19 43.44 Quite Low
alcohol 29 31.20 Quite Low
Bile 6 30.88 Quite Low
adenocard 2 22.60 Low Low
fibrosis 4 17.68 Low Low
metalloproteinase 14 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 441 100.00 Very High Very High Very High
Pressure And Volume Under Development 19 99.92 Very High Very High Very High
Hyperlipidemia 54 99.86 Very High Very High Very High
Hyperglycemia 31 99.52 Very High Very High Very High
Stress 77 99.44 Very High Very High Very High
Hypercholesterolemia 2 99.24 Very High Very High Very High
Metabolic Syndrome 154 98.52 Very High Very High Very High
Coronary Artery Disease 13 98.08 Very High Very High Very High
Diabetes Mellitus 494 98.06 Very High Very High Very High
Renal Disease 8 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Elevated VLDL and LDL with depressed HDL (unpublished data) and renal dysfunction with microalbuminuria along with cataracts and other complications associated with progressive diabetes were also observed (data not shown).


Positive_regulation (Elevated) of VLDL associated with diabetes mellitus, renal disease, cataract and disorder of lipid metabolism
1) Confidence 0.67 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2868017 Disease Relevance 0.99 Pain Relevance 0
The increased VLDL, triglycerides, atherogenic small dense LDL cholesterol and the diminished amount of the anti-atherogenic, antioxidant anti-inflammatory high density lipoprotein cholesterol would reduce the natural antioxidant reserve.
Positive_regulation (increased) of VLDL associated with inflammation
2) Confidence 0.67 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 1.14 Pain Relevance 0.05
This drug eliminated the radializing effect of reelin, suggesting that activation of ApoER2 and VLDL receptors is necessary (Figure 4E,J).
Positive_regulation (activation) of VLDL
3) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0
Niacin also increases apo-B100 catabolism causing reduced VLDL and triglyceride secretion by the liver.
Positive_regulation (causing) of VLDL in liver
4) Confidence 0.49 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.05 Pain Relevance 0
While in control rats Chol/TG ratio increased in IDL with respect to VLDL (VLDL: 0.11 ± 0.021 vs.
Positive_regulation (increased) of VLDL associated with disorder of lipid metabolism
5) Confidence 0.49 Published 2010 Journal Diabetol Metab Syndr Section Body Doc Link PMC2847988 Disease Relevance 1.40 Pain Relevance 0
An increased level of total cholesterol, LDL-C, VLDL-C, triglycerides, phospholipids and free fatty acids, and decreased level of HDL-C were observed in ethanol-intoxicated rats.
Positive_regulation (increased) of VLDL associated with disorder of lipid metabolism
6) Confidence 0.45 Published 2010 Journal Pharmacognosy Magazine Section Body Doc Link PMC2881655 Disease Relevance 0.37 Pain Relevance 0
In the lipid profiles, the levels of total cholesterol (TC), triglycerides (TG), low density lipoproteins (LDL), very low density lipoproteins (VLDL), free fatty acids (FFA), and phospholipids were significantly elevated in the ethanol-induced group, whereas, the high density lipoproteins (HDL) were found to be reduced in the plasma, and the phospholipid levels were significantly decreased in the tissues.
Positive_regulation (elevated) of VLDL in plasma associated with disorder of lipid metabolism
7) Confidence 0.45 Published 2010 Journal Pharmacognosy Magazine Section Abstract Doc Link PMC2881655 Disease Relevance 0.48 Pain Relevance 0
Also, serum TC, TG, LDL and VLDL-cholesterol level elevated significantly (P < 0.05), whereas HDL-cholesterol reduced significantly (P < 0.05) in group II (alloxan-treated diabetic control).
Positive_regulation (elevated) of VLDL associated with diabetes mellitus and disorder of lipid metabolism
8) Confidence 0.45 Published 2009 Journal Indian J. Biochem. Biophys. Section Abstract Doc Link 19374261 Disease Relevance 0.64 Pain Relevance 0.07
Slower progressing diabetes in older Nile rats also was associated with a much greater hyperglycemia and hyperlipemia, with elevated VLDL-TG (up to10-fold), total cholesterol (5-fold) and HDL depressed to 1/5 normal (unpublished data).
Positive_regulation (elevated) of VLDL associated with hyperglycemia, diabetes mellitus, hyperlipidemia and disorder of lipid metabolism
9) Confidence 0.45 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2868017 Disease Relevance 1.38 Pain Relevance 0
For example, the plasma VLDL and LDL levels do not increase and the HDL levels are elevated upon high-fat diet feeding, which findings are in contrast to those often noted in humans [5].
Neg (not) Positive_regulation (increase) of VLDL in fat associated with disorder of lipid metabolism
10) Confidence 0.45 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266061 Disease Relevance 1.71 Pain Relevance 0
HMG-CoA reductase inhibitors (statin group of drugs) like atorvastatin, simvastain, and rosuvastatin reduces raised triglyceride levels caused by elevated VLDL levels.
Positive_regulation (elevated) of VLDL
11) Confidence 0.45 Published 2010 Journal Journal of Pharmacy and Bioallied Sciences Section Body Doc Link PMC2996074 Disease Relevance 0.12 Pain Relevance 0

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