INT159443

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Context Info
Confidence 0.57
First Reported 2007
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 9
Total Number 12
Disease Relevance 6.63
Pain Relevance 5.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpm8) transmembrane transport (Trpm8)
Anatomy Link Frequency
Nerve 2
peripheral nervous system 2
Trpm8 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 25 100.00 Very High Very High Very High
Cold hyperalgesia 23 99.76 Very High Very High Very High
Neuropathic pain 54 99.70 Very High Very High Very High
induced neuropathy 24 99.38 Very High Very High Very High
Peripheral nervous system 6 99.26 Very High Very High Very High
analgesia 13 99.12 Very High Very High Very High
allodynia 90 98.84 Very High Very High Very High
Pain 158 98.12 Very High Very High Very High
peripheral neuropathy 10 96.20 Very High Very High Very High
TRP channel 58 95.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypersensitivity 166 99.90 Very High Very High Very High
Injury 151 99.82 Very High Very High Very High
Hyperalgesia 108 99.76 Very High Very High Very High
Neuropathic Pain 198 99.70 Very High Very High Very High
Pain 124 98.12 Very High Very High Very High
Peripheral Neuropathy 1 96.20 Very High Very High Very High
Nervous System Injury 68 95.84 Very High Very High Very High
Ganglion Cysts 143 93.44 High High
Cancer 12 90.08 High High
Nociception 66 84.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nerve-injury induced changes in the expression of TRPM8 and TRPA1
Regulation (changes) of Gene_expression (expression) of TRPM8 in Nerve associated with injury
1) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 1.27 Pain Relevance 0.92
Our present study shows that mice with oxaliplatin-induced cold hyperalgesia had little change in TRPM8 transcripts expression.
Neg (little) Regulation (change) of Gene_expression (expression) of TRPM8 associated with hyperalgesia and cold hyperalgesia
2) Confidence 0.52 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 0.54 Pain Relevance 0.49
Could it be that there are multiple populations of TRPM8-expressing afferents, with some mediating analgesia and some mediating cold hypersensitivity?
Regulation (populations) of Gene_expression (afferents) of TRPM8-expressing associated with hypersensitivity and analgesia
3) Confidence 0.45 Published 2007 Journal Mol Pain Section Body Doc Link PMC1988789 Disease Relevance 0.58 Pain Relevance 0.82
Imidazole, on the other hand, was ineffective at both the TRPM8 wild-type and Y745H mutant channels, at concentrations of 20 ?
Regulation (ineffective) of Gene_expression (wild-type) of TRPM8
4) Confidence 0.45 Published 2009 Journal Mol Pain Section Body Doc Link PMC2778643 Disease Relevance 0 Pain Relevance 0.25
The finding from experiments in genetically modified mice that menthol-induced cold hypersensitivity was not obviously influenced by TRPM8 expression but was dependent on TRPA1 expression was initially surprising.
Neg (not) Regulation (influenced) of Gene_expression (expression) of TRPM8 associated with hypersensitivity
5) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC2822744 Disease Relevance 0.37 Pain Relevance 0.15
In contrast, expression of TRPM8 was only minimally affected even in the pathological condition, while TRPV1 and TRPV2 showed early recovery after methimazole treatment.



Regulation (affected) of Gene_expression (expression) of TRPM8
6) Confidence 0.43 Published 2010 Journal Acta Oto-Laryngologica Section Body Doc Link PMC2981077 Disease Relevance 0 Pain Relevance 0.07
This suggests that cold hypersensitivity in neuropathic pain is not always dependent upon increased expression of TRPA1 and TRPM8 in DRG.


Neg (not) Regulation (dependent) of Gene_expression (expression) of TRPM8 associated with hypersensitivity and neuropathic pain
7) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 0.68 Pain Relevance 0.29
In this study, we used models of cisplatin and oxaliplatin-induced neuropathy to investigate whether TRPV1, TRPM8, and TRPA1 mRNA expression were altered along with changes in thermal sensitivity observed in chemotherapeutic neuropathy.
Spec (whether) Regulation (altered) of Gene_expression (expression) of TRPM8 associated with induced neuropathy and neuropathic pain
8) Confidence 0.38 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 1.15 Pain Relevance 0.70
To determine whether the neurotoxic effects on the peripheral nervous system from platinum drug exposure induces changes in the expression of TRPV1, TRPM8, and TRPA1 mRNA, we used a previously described cell culture model [50].
Spec (whether) Regulation (changes) of Gene_expression (expression) of TRPM8 in peripheral nervous system associated with peripheral nervous system
9) Confidence 0.38 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 0.92 Pain Relevance 0.56
In contrast, menthol-induced cold hypersensitivity was dependent on expression of TRPA1 and not TRPM8.



Regulation (dependent) of Gene_expression (expression) of TRPM8 associated with hypersensitivity
10) Confidence 0.27 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2822744 Disease Relevance 0.60 Pain Relevance 0.20
In contrast, expression of TRPM8 was scarcely affected, even in the pathological condition, while TRPV1 and TRPV2 showed early recovery following methimazole treatment.



Regulation (affected) of Gene_expression (expression) of TRPM8
11) Confidence 0.26 Published 2010 Journal Acta Oto-Laryngologica Section Abstract Doc Link PMC2981077 Disease Relevance 0 Pain Relevance 0.04
Involvement of increased expression of transient receptor potential melastatin 8 in oxaliplatin-induced cold allodynia in mice.
Regulation (Involvement) of Gene_expression (expression) of transient receptor potential melastatin 8 associated with qutenza and allodynia
12) Confidence 0.24 Published 2009 Journal Neurosci. Lett. Section Title Doc Link 19375484 Disease Relevance 0.49 Pain Relevance 0.64

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