INT159464

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Context Info
Confidence 0.37
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.07
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Accn1) plasma membrane (Accn1)
Anatomy Link Frequency
MSNs 2
Accn1 (Mus musculus)
Pain Link Frequency Relevance Heat
ASIC 26 100.00 Very High Very High Very High
agonist 4 98.36 Very High Very High Very High
PcTx1 3 93.52 High High
bradykinin 3 89.20 High High
medulla 4 87.68 High High
Calcitonin gene-related peptide 7 87.64 High High
Inflammation 20 82.96 Quite High
antagonist 1 78.36 Quite High
qutenza 3 78.24 Quite High
sodium channel 3 76.08 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 3 99.60 Very High Very High Very High
Acidosis 14 85.28 High High
Deafness 6 83.52 Quite High
INFLAMMATION 21 82.96 Quite High
Neurodegenerative Disease 1 76.16 Quite High
Targeted Disruption 6 67.00 Quite High
Cough 2 57.52 Quite High
Pain 13 54.84 Quite High
Cancer 2 45.00 Quite Low
Injury 7 44.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ASIC currents were diminished in MSNs from ASIC1, but not ASIC2, null mice.
Negative_regulation (diminished) of ASIC in MSNs associated with asic
1) Confidence 0.37 Published 2009 Journal Neuroscience Section Abstract Doc Link 19376200 Disease Relevance 0.08 Pain Relevance 0.42
The proton-induced response in spiral ganglion neurons is largely reduced in Asic2?
Negative_regulation (reduced) of Asic2 in neurons associated with ganglion cysts
2) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714966 Disease Relevance 0.27 Pain Relevance 0.21
We found that pH 7.0 significantly potentiated AGM response and the potentiation was always more than additive with pH reduction regardless the sequence of agonist application (Figure 2D, E), a characteristic that is opposite to the accelerated ASIC desensitization caused by pretreatment with acidic solution [36].
Negative_regulation (desensitization) of ASIC associated with agonist and asic
3) Confidence 0.04 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.45 Pain Relevance 0.21
Coadministration of amiloride (30 microm), the blocker of acid-sensing ion channels, was ineffective in both TRPV1 genotypes.
Negative_regulation (blocker) of acid-sensing
4) Confidence 0.03 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19473241 Disease Relevance 0.27 Pain Relevance 0.57

General Comments

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