INT159472

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Context Info
Confidence 0.79
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 32
Total Number 32
Disease Relevance 33.67
Pain Relevance 3.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (NPPB) extracellular region (NPPB) nucleus (NPPB)
cytoplasm (NPPB)
Anatomy Link Frequency
ventricle 6
heart 6
cardiomyocytes 3
brain 2
terminal portion 2
NPPB (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 259 99.44 Very High Very High Very High
thoracic epidural anesthesia 1 99.40 Very High Very High Very High
cva 58 99.26 Very High Very High Very High
imagery 38 96.20 Very High Very High Very High
Catecholamine 27 96.20 Very High Very High Very High
Inflammation 263 91.92 High High
cytokine 63 91.04 High High
Potency 3 89.32 High High
depression 8 82.20 Quite High
Angina 383 79.44 Quite High
Disease Link Frequency Relevance Heat
Natriuresis 282 100.00 Very High Very High Very High
Exanthema 8 99.96 Very High Very High Very High
Heart Rate Under Development 153 99.92 Very High Very High Very High
Injury 424 99.84 Very High Very High Very High
Diarrhoea 8 99.84 Very High Very High Very High
Lymphopenia 4 99.80 Very High Very High Very High
Cv Unclassified Under Development 190 99.44 Very High Very High Very High
Diuresis 25 99.40 Very High Very High Very High
Diabetes Mellitus 174 99.36 Very High Very High Very High
Disease 127 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVES: The purpose of this study was to evaluate the effects of thoracic epidural anesthesia on postoperative N-terminal pro B-natriuretic peptide (NT-proBNP) release in elderly patients undergoing elective coronary artery bypass graft (CABG) surgery.
Localization (release) of N-terminal pro B-natriuretic peptide in thoracic associated with natriuresis and thoracic epidural anesthesia
1) Confidence 0.79 Published 2009 Journal J. Cardiothorac. Vasc. Anesth. Section Abstract Doc Link 19376734 Disease Relevance 0.10 Pain Relevance 0.21
Regarding the origin of BNP, Yasue and colleagues [22] determined that BNP is secreted mainly from the left ventricle in healthy adults as well as in patients with left ventricular dysfunction.
Localization (secreted) of BNP in ventricle associated with left ventricular dysfunction
2) Confidence 0.70 Published 2008 Journal Crit Care Section Body Doc Link PMC2592747 Disease Relevance 1.20 Pain Relevance 0.16
Conversely, it is also possible that overweight and obesity are associated with less robust synthesis and/or release of BNP from the myocardium.5) In the present study, NT-proBNP concentrations were lower in obese non DM patients despite higher E/Ea which has been shown to correlate with invasive measures of LV filling pressure24) and this occurs with presence of myocardial ischemia confirmed by coronary angiography.
Localization (release) of BNP in myocardium associated with coronary artery disease, diabetes mellitus, ischemia, obesity and overweight
3) Confidence 0.69 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2801462 Disease Relevance 2.00 Pain Relevance 0.08
In general, BNP is a peptide hormone secreted by the ventricular myocardial in response to wall stress [3].
Localization (secreted) of BNP associated with stress
4) Confidence 0.68 Published 2010 Journal Crit Care Section Body Doc Link PMC2887156 Disease Relevance 1.11 Pain Relevance 0.17
It is secreted equimolarly with BNP by the ventricle wall mainly in response to wall stretch and its secretion may be enhanced by catecholamine’s, angiotensin II, endothelin and hypoxia (Hall 2005).
Localization (secreted) of BNP in ventricle associated with hypoxia and catecholamine
5) Confidence 0.65 Published 2008 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2515587 Disease Relevance 0.32 Pain Relevance 0.05
In the present study, patients with intracranial hemorrhage were excluded in order to eliminate alteration of BNP caused by total body irradiation (TBI).
Localization (alteration) of BNP in body associated with cva
6) Confidence 0.65 Published 2008 Journal Crit Care Section Body Doc Link PMC2592747 Disease Relevance 0.76 Pain Relevance 0.09
Regarding the issue of BNP alteration in trauma patients, Kia and colleagues [15] reported BNP levels below normal as an indicator for intravascular volume loss and therefore as an initial marker of bleeding.
Localization (alteration) of BNP associated with injury and hemorrhage
7) Confidence 0.65 Published 2008 Journal Crit Care Section Body Doc Link PMC2592747 Disease Relevance 0.72 Pain Relevance 0.04
Regarding the origin of BNP, Yasue and colleagues [22] determined that BNP is secreted mainly from the left ventricle in healthy adults as well as in patients with left ventricular dysfunction.
Localization (secreted) of BNP in ventricle associated with left ventricular dysfunction
8) Confidence 0.61 Published 2008 Journal Crit Care Section Body Doc Link PMC2592747 Disease Relevance 1.22 Pain Relevance 0.16
They also showed that increased wall tension of the left ventricle results in an increase in the rate of BNP secretion.
Localization (secretion) of BNP in ventricle
9) Confidence 0.61 Published 2008 Journal Crit Care Section Body Doc Link PMC2592747 Disease Relevance 1.32 Pain Relevance 0.20
BNP is a 32-amino acid protein released from cardiac ventricles in response to myocyte stretch.
Localization (released) of BNP in myocyte
10) Confidence 0.61 Published 2008 Journal Crit Care Section Body Doc Link PMC2592747 Disease Relevance 1.03 Pain Relevance 0.14
NT-proBNP is cleaved from proBNP when it is converted into active BNP upon secretion.
Localization (secretion) of BNP
11) Confidence 0.61 Published 2008 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2515587 Disease Relevance 0.30 Pain Relevance 0.04
Moreover, DM patients may be more likely to excrete NT-proBNP (and BNP) in response to a similar degree of ischemic insult,27) and then the higher NT-proBNP concentrations that we observed in patients with DM in the absence of overt HF, a finding considered to represent a "summation effect" of risk factors for structural heart disease, may still indicate an increased risk for cardiovascular morbidity and mortality.
Localization (excrete) of NT-proBNP in heart associated with heart disease and diabetes mellitus
12) Confidence 0.61 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2801462 Disease Relevance 1.42 Pain Relevance 0.20
Moreover, DM patients may be more likely to excrete NT-proBNP (and BNP) in response to a similar degree of ischemic insult,27) and then the higher NT-proBNP concentrations that we observed in patients with DM in the absence of overt HF, a finding considered to represent a "summation effect" of risk factors for structural heart disease, may still indicate an increased risk for cardiovascular morbidity and mortality.
Localization (excrete) of BNP in heart associated with heart disease and diabetes mellitus
13) Confidence 0.61 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2801462 Disease Relevance 1.42 Pain Relevance 0.20
B-type natriuretic peptide (BNP) is a 32-amino-acid peptide secreted mainly by the cardiac ventricles in response to pressure or volume overloading (ventricular stretch) [6].
Localization (secreted) of BNP in cardiac ventricles associated with natriuresis
14) Confidence 0.44 Published 2008 Journal Crit Care Section Body Doc Link PMC2481437 Disease Relevance 1.41 Pain Relevance 0.12
This biomarker has a short half-life but is released with the N-terminal portion of the pro-BNP peptide (NTproBNP), a peptide much more stable in serum and can be measured easily [31].
Localization (released) of NTproBNP in terminal portion
15) Confidence 0.30 Published 2010 Journal BMC Med Section Body Doc Link PMC2898678 Disease Relevance 0.96 Pain Relevance 0
This biomarker has a short half-life but is released with the N-terminal portion of the pro-BNP peptide (NTproBNP), a peptide much more stable in serum and can be measured easily [31].
Localization (released) of pro-BNP peptide in terminal portion
16) Confidence 0.30 Published 2010 Journal BMC Med Section Body Doc Link PMC2898678 Disease Relevance 0.91 Pain Relevance 0
BNP expression and release from cardiomyocites can also be stimulated by a variety of endocrine, paracrine and autocrine factors that are activated in heart failure, including norepinephrine, angiotensin II, ET-1, glucocorticoids and proinflammatory cytokines.
Localization (release) of BNP in heart associated with myocardial infarction and cytokine
17) Confidence 0.26 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 1.05 Pain Relevance 0.05
B-type natriuretic peptide (BNP) is preferentially produced and secreted in the left ventricle, although the right side of the human heart also synthesises and secretes BNP in response to disease (Kay JD et al. 2003).
Localization (secreted) of BNP in heart associated with natriuresis and disease
18) Confidence 0.26 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 0.60 Pain Relevance 0.03
Secreted by the ventricles in response to cardiomyocytes under tension [27], BNP binds and activates receptors causing reduction in systemic vascular resistance, central venous pressure and natriuresis.
Localization (Secreted) of BNP in cardiomyocytes associated with natriuresis
19) Confidence 0.24 Published 2010 Journal BMC Med Section Body Doc Link PMC2898678 Disease Relevance 0.99 Pain Relevance 0.05
Like BNP it is released in proportion to the severity of heart failure [73,74], and is inversely related to the left ventricular ejection fraction (LVEF)[75,76].
Localization (released) of BNP in heart associated with myocardial infarction
20) Confidence 0.24 Published 2010 Journal BMC Med Section Body Doc Link PMC2898678 Disease Relevance 1.03 Pain Relevance 0

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