INT159477

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Context Info
Confidence 0.72
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 1.54
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (NOS3) aging (NOS3) Golgi apparatus (NOS3)
mitochondrion organization (NOS3) cytoplasm (NOS3) cytosol (NOS3)
Anatomy Link Frequency
platelets 3
endothelial cells 1
NOS3 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 757 99.44 Very High Very High Very High
Inflammation 29 61.84 Quite High
cytokine 14 60.80 Quite High
aspirin 12 50.00 Quite Low
bradykinin 12 12.40 Low Low
Kinase C 10 5.00 Very Low Very Low Very Low
COX2 10 5.00 Very Low Very Low Very Low
b2 receptor 9 5.00 Very Low Very Low Very Low
Angina 9 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 27 92.64 High High
Metabolic Syndrome 15 90.00 High High
Hypertension 29 89.52 High High
Diabetes Mellitus 83 88.96 High High
Bacterial Respiratory Disease 4 86.96 High High
Increased Venous Pressure Under Development 46 77.60 Quite High
Apoptosis 98 72.92 Quite High
Stress 49 66.48 Quite High
INFLAMMATION 32 61.84 Quite High
Hyperlipidemia 4 59.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serine phosphorylation of NOS-3 in platelets was decreased, and this was especially marked for serine-1177 phosphorylation, whereas acetylation of NOS-3 was increased, by aspirin incubation.
Phosphorylation (phosphorylation) of NOS-3 in platelets
1) Confidence 0.72 Published 2009 Journal Cardiovasc. Res. Section Body Doc Link 19377066 Disease Relevance 0 Pain Relevance 0
Serine phosphorylation of NOS-3 in platelets was decreased, and this was especially marked for serine-1177 phosphorylation, whereas acetylation of NOS-3 was increased, by aspirin incubation.
Phosphorylation (acetylation) of NOS-3 in platelets
2) Confidence 0.71 Published 2009 Journal Cardiovasc. Res. Section Body Doc Link 19377066 Disease Relevance 0 Pain Relevance 0
Serine phosphorylation of NOS-3 in platelets was decreased, and this was especially marked for serine-1177 phosphorylation, whereas acetylation of NOS-3 was increased, by aspirin incubation.
Phosphorylation (phosphorylation) of NOS-3 in platelets
3) Confidence 0.55 Published 2009 Journal Cardiovasc. Res. Section Body Doc Link 19377066 Disease Relevance 0 Pain Relevance 0
In fact the level of eNOS phosphorylation in response to U46619 was comparable, if not greater, than those levels detected in response to stimulation of cells with thrombin (Fig. 9C), an agent that has recently been established to lead to rapid phosphorylation of eNOS at Ser1177/1179 leading to its activation [56].
Phosphorylation (phosphorylation) of eNOS
4) Confidence 0.32 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.08
-regulated PKC activation and phosphorylation of Ser145 and Thr337 and another involving eNOS phosphorylation and activation leading the NO/cGMP-regulated PKG phosphorylation of Ser331.
Phosphorylation (phosphorylation) of eNOS
5) Confidence 0.32 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.16
Normally, stimulation of NO production by insulin is mediated by signaling pathways involving activation of Phosphoinositide-3 (PI-3) kinase leading to phosphorylation of eNOS.
Phosphorylation (phosphorylation) of eNOS
6) Confidence 0.31 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.14 Pain Relevance 0.06
cells (data not shown), led to the rapid phosphorylation of endogenous eNOS at Ser1177 to levels comparable, if not greater, than those in response to thrombin stimulation.
Phosphorylation (phosphorylation) of eNOS
7) Confidence 0.29 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.21
In fact the level of eNOS phosphorylation in response to U46619 was comparable, if not greater, than those levels detected in response to stimulation of cells with thrombin (Fig. 9C), an agent that has recently been established to lead to rapid phosphorylation of eNOS at Ser1177/1179 leading to its activation [56].
Phosphorylation (phosphorylation) of eNOS
8) Confidence 0.29 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.12
This, in turn, triggers the rapid and dynamic activation of Ca2+/calmodulin-sensitive NO synthases (NOS), such as through Ser1177 phosphorylation and activation of eNOS, promoting the synthesis of NO from l-Arg.
Phosphorylation (phosphorylation) of eNOS
9) Confidence 0.29 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.13
Furthermore, as stated, through further recent studies it has been demonstrated that thrombin can directly lead to eNOS phosphorylation at Ser1177/1179 in bovine aortic endothelial cells in a mechanism involving Gq/PLC?
Phosphorylation (phosphorylation) of eNOS in endothelial cells
10) Confidence 0.29 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0.12 Pain Relevance 0.03
Phosphorylation of eNOS at Ser1177 (Human)/1179 (Bovine) by phosphatidylinositol 3-kinase (PI3-K)-dependent AKT or, as more recently demonstrated, by Gq/PLC?
Phosphorylation (Phosphorylation) of eNOS
11) Confidence 0.29 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.20
Analysis of NOS expression and eNOS phosphorylation
Phosphorylation (phosphorylation) of eNOS
12) Confidence 0.28 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.04
Whilst our data have indeed confirmed that both thrombin and U46619 can readily lead to eNOS phosphorylation at Ser1177 in HEK 293 cells, we have not explored whether that eNOS activation occurs through PKC?
Phosphorylation (phosphorylation) of eNOS
13) Confidence 0.28 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0.05 Pain Relevance 0.04
Ceramide release stimulated the phosphorylation of twelve protein kinases: p27T198, eNOS, CREB, Fyn (all 2.3-fold), Hck, PLC?
Phosphorylation (phosphorylation) of eNOS
14) Confidence 0.11 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0.17 Pain Relevance 0

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