INT159479

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.63
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (NOS3) aging (NOS3) Golgi apparatus (NOS3)
mitochondrion organization (NOS3) cytoplasm (NOS3) cytosol (NOS3)
Anatomy Link Frequency
platelets 2
NOS3 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 4 99.70 Very High Very High Very High
cINOD 1 96.28 Very High Very High Very High
b2 receptor 1 88.88 High High
bradykinin 1 82.48 Quite High
agonist 93 79.68 Quite High
Bioavailability 1 64.00 Quite High
Inflammation 1 49.20 Quite Low
Tetrahydrobiopterin 1 39.20 Quite Low
Central nervous system 5 5.00 Very Low Very Low Very Low
substance P 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 4 100.00 Very High Very High Very High
Stress 13 96.56 Very High Very High Very High
INFLAMMATION 2 96.04 Very High Very High Very High
Increased Venous Pressure Under Development 24 63.72 Quite High
Hyperlipidemia 1 53.52 Quite High
Diabetes Mellitus 1 51.76 Quite High
Obesity 1 50.96 Quite High
Hypertension 4 5.00 Very Low Very Low Very Low
Muscular Dystrophy 4 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of the present study was to determine the mechanism by which aspirin acutely increases the activity of NO synthase type 3 (NOS-3), the predominant NOS isoform expressed by platelets, and specifically whether this occurs through an increase in its acetylation.
Positive_regulation (increases) of NOS-3 Binding (activity) of in platelets associated with aspirin
1) Confidence 0.50 Published 2009 Journal Cardiovasc. Res. Section Abstract Doc Link 19377066 Disease Relevance 0.10 Pain Relevance 0.23
The functional association between vascular nNOS and eNOS with respect to the regulation of tone and how this may be altered in disease settings also requires further study.
Positive_regulation (requires) of eNOS Binding (association) of associated with disease
2) Confidence 0.34 Published 2009 Journal Trends in Cardiovascular Medicine Section Body Doc Link PMC2984617 Disease Relevance 0.53 Pain Relevance 0.06
While we have not been able to find any evidence for a direct interaction between eNOS and TP?
Spec (find) Positive_regulation (find) of eNOS Binding (interaction) of
3) Confidence 0.17 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.13

General Comments

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