INT159489

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 6.02
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Csf2) extracellular region (Csf2)
Anatomy Link Frequency
macrophage 4
blood 2
CSF 2
Csf2 (Mus musculus)
Pain Link Frequency Relevance Heat
intrathecal 2 99.20 Very High Very High Very High
qutenza 3 97.36 Very High Very High Very High
Neuritis 1 97.32 Very High Very High Very High
Spinal cord 2 95.60 Very High Very High Very High
Glutamate 4 94.64 High High
methotrexate 4 93.92 High High
Inflammation 132 89.40 High High
substance P 1 88.00 High High
Antinociceptive 5 84.32 Quite High
Angina 5 82.80 Quite High
Disease Link Frequency Relevance Heat
Pulmonary Alveolar Proteinosis 34 100.00 Very High Very High Very High
Asthma 315 99.52 Very High Very High Very High
Stress 68 99.24 Very High Very High Very High
Convulsion 1 99.12 Very High Very High Very High
Neuritis 1 97.32 Very High Very High Very High
Infection 24 97.24 Very High Very High Very High
Injury 18 96.28 Very High Very High Very High
Nociception 1 95.52 Very High Very High Very High
Disease 54 94.08 High High
Syndrome 22 93.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Remarkably, exceeding matrix deterioration was associated with massively increased levels of granulocyte macrophage colony stimulating factor (GM-CSF).


Positive_regulation (levels) of Positive_regulation (increased) of granulocyte macrophage colony stimulating factor in macrophage
1) Confidence 0.42 Published 2010 Journal J Cardiothorac Surg Section Abstract Doc Link PMC2933604 Disease Relevance 0.70 Pain Relevance 0.12
Remarkably, exceeding matrix deterioration was associated with massively increased levels of granulocyte macrophage colony stimulating factor (GM-CSF).


Positive_regulation (increased) of Positive_regulation (levels) of GM-CSF in macrophage
2) Confidence 0.42 Published 2010 Journal J Cardiothorac Surg Section Abstract Doc Link PMC2933604 Disease Relevance 0.70 Pain Relevance 0.12
Intrathecal administration of guanosine (200 nmol) induced an approximately 120-fold increase on CSF guanosine levels.
Positive_regulation (induced) of Positive_regulation (increase) of CSF in CSF associated with intrathecal
3) Confidence 0.40 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19379722 Disease Relevance 0.21 Pain Relevance 1.00
This might also be caused by GM-CSF induction through emotional stress and this leads to the overproduction of ROS to damage tissues.
Positive_regulation (caused) of Positive_regulation (induction) of GM-CSF associated with stress
4) Confidence 0.12 Published 2007 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1876613 Disease Relevance 0.95 Pain Relevance 0.03
These are the first results to demonstrate familial primary PAP in humans and that GM-CSF-R?
Positive_regulation (familial) of Positive_regulation (primary) of GM-CSF associated with pulmonary alveolar proteinosis
5) Confidence 0.11 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585845 Disease Relevance 0.55 Pain Relevance 0
Recent evidence indicates that high levels of S100 B in CSF increase the risk of repeated seizures in children with severe P. falciparum infection due to axonal injury [60].
Positive_regulation (increase) of Positive_regulation (levels) of CSF associated with convulsion, injury and infection
6) Confidence 0.10 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2442079 Disease Relevance 2.14 Pain Relevance 0.10
Cyclosporin A inhibits the allergen-induced late asthmatic reaction, the allergen-induced increase in IL-5 and GM-CSF in mRNA+ cells in BAL, and in the number of eosinophils in blood and bronchial mucosa, but not the early asthmatic reaction [8].
Positive_regulation (induced) of Positive_regulation (increase) of GM-CSF in blood associated with asthma
7) Confidence 0.04 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.77 Pain Relevance 0.24

General Comments

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