INT159500

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Context Info
Confidence 0.57
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 1.02
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SGCG) cytoskeleton (SGCG) cytoskeleton organization (SGCG)
cytoplasm (SGCG)
Anatomy Link Frequency
chondrocytes 4
osteoblasts 2
SGCG (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 9 78.16 Quite High
Snapping jaw 12 72.16 Quite High
Osteoarthritis 9 64.64 Quite High
Disease Link Frequency Relevance Heat
Temporomandibular Joint Syndrome 12 72.16 Quite High
Disease 3 67.20 Quite High
Osteoarthritis 9 64.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We confirmed a significant decrease in type II collagen and aggrecan mRNA expressions in chondrocytes by co-culture with osteoblasts after impact-loading, and significant increase in mRNA and protein expressions of IL-1beta in subchondral osteoblasts from impact-loaded subchondral bone.
Negative_regulation (decrease) of Transcription (expressions) of type in osteoblasts
1) Confidence 0.57 Published 2009 Journal Ann Biomed Eng Section Abstract Doc Link 19381811 Disease Relevance 0.33 Pain Relevance 0.26
The mRNA expressions of type II collagen, aggrecan, and type X collagen in chondrocytes were decreased significantly by the co-culture with osteoblasts pre-treated by IL-1beta, -6, and TNF-alpha.
Negative_regulation (decreased) of Transcription (expressions) of type in chondrocytes
2) Confidence 0.41 Published 2009 Journal Ann Biomed Eng Section Abstract Doc Link 19381811 Disease Relevance 0.35 Pain Relevance 0.39
The mRNA expressions of type II collagen, aggrecan, and type X collagen in chondrocytes were decreased significantly by the co-culture with osteoblasts pre-treated by IL-1beta, -6, and TNF-alpha.
Negative_regulation (decreased) of Transcription (expressions) of type in chondrocytes
3) Confidence 0.41 Published 2009 Journal Ann Biomed Eng Section Abstract Doc Link 19381811 Disease Relevance 0.35 Pain Relevance 0.39

General Comments

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