INT159518

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Context Info
Confidence 0.35
First Reported 2008
Last Reported 2009
Negated 0
Speculated 2
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 2.34
Pain Relevance 6.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Clock) chromosome (Clock) nucleus (Clock)
DNA binding (Clock) cytoplasm (Clock) signal transducer activity (Clock)
Anatomy Link Frequency
nucleus accumbens 1
blood 1
brain 1
amygdala 1
hippocampus 1
Clock (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 50 99.84 Very High Very High Very High
Nucleus accumbens 15 98.68 Very High Very High Very High
amygdala 15 97.92 Very High Very High Very High
withdrawal 25 97.28 Very High Very High Very High
Hippocampus 7 96.14 Very High Very High Very High
Cluster headache 15 94.56 High High
Ventral tegmentum 5 85.92 High High
Central nervous system 5 82.80 Quite High
Migraine 101 55.36 Quite High
headache 39 54.24 Quite High
Disease Link Frequency Relevance Heat
Iron Overload 1 97.12 Very High Very High Very High
Cluster Headache 39 94.56 High High
Ocular Toxicity (including Many Sub-types) 5 92.16 High High
Weight Loss 5 91.20 High High
Disease 16 82.28 Quite High
Recurrence 4 75.04 Quite High
Paresis 1 60.24 Quite High
Migraine With Aura 46 55.36 Quite High
Headache 84 54.24 Quite High
Channelopathies 5 54.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A blunting of circadian oscillations of rPER1 expression occurred in the central amygdala, hippocampus, nucleus accumbens core, and PBMCs and rPER2 expression occurred in the central amygdala, prefrontal cortex, nucleus accumbens core, and PBMCs in morphine-treated rats compared with controls. rCLOCK expression in morphine-treated rats showed no rhythmic change, identical to control rats.
Gene_expression (expression) of rCLOCK in nucleus accumbens associated with nucleus accumbens, hippocampus, amygdala and morphine
1) Confidence 0.35 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19383088 Disease Relevance 0.15 Pain Relevance 1.33
Other genes, such as the NO synthases NOS1, NOS2A and NOS3 [154], the elusive amine gene cluster [155], the CLOCK gene involved in the regulation of circadian rhythms [156,157] and the hemochromatosis gene [158], have been found not associated with CH.
Gene_expression (synthases) of CLOCK associated with cluster headache and iron overload
2) Confidence 0.31 Published 2008 Journal J Headache Pain Section Body Doc Link PMC2276243 Disease Relevance 1.53 Pain Relevance 0.89
Then, brain and blood samples were collected at each of eight time points (every 3 h: ZT 9; ZT 12; ZT 15; ZT 18; ZT 21; ZT 0; ZT 3; ZT 6) to examine expression of rPER1 and rPER2 and rCLOCK.
Spec (examine) Gene_expression (expression) of rCLOCK in brain
3) Confidence 0.27 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19383088 Disease Relevance 0.18 Pain Relevance 1.01
A blunting of circadian oscillations of rPER1 expression occurred in the central amygdala, hippocampus, nucleus accumbens core, and PBMCs and rPER2 expression occurred in the central amygdala, prefrontal cortex, nucleus accumbens core, and PBMCs in morphine-treated rats compared with controls. rCLOCK expression in morphine-treated rats showed no rhythmic change, identical to control rats.
Gene_expression (expression) of rCLOCK in amygdala associated with nucleus accumbens, hippocampus, amygdala and morphine
4) Confidence 0.12 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19383088 Disease Relevance 0.15 Pain Relevance 1.33
A blunting of circadian oscillations of rPER1 expression occurred in the central amygdala, hippocampus, nucleus accumbens core, and PBMCs and rPER2 expression occurred in the central amygdala, prefrontal cortex, nucleus accumbens core, and PBMCs in morphine-treated rats compared with controls. rCLOCK expression in morphine-treated rats showed no rhythmic change, identical to control rats.
Gene_expression (expression) of rCLOCK in hippocampus associated with nucleus accumbens, hippocampus, amygdala and morphine
5) Confidence 0.12 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19383088 Disease Relevance 0.15 Pain Relevance 1.33
Then, brain and blood samples were collected at each of eight time points (every 3 h: ZT 9; ZT 12; ZT 15; ZT 18; ZT 21; ZT 0; ZT 3; ZT 6) to examine expression of rPER1 and rPER2 and rCLOCK.
Spec (examine) Gene_expression (expression) of rCLOCK in blood
6) Confidence 0.09 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19383088 Disease Relevance 0.18 Pain Relevance 1.01

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