INT159531

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 9.30
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (SLC17A5) plasma membrane (SLC17A5) transmembrane transport (SLC17A5)
Anatomy Link Frequency
kidney 5
liver 3
arm 2
SLC17A5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 69 99.32 Very High Very High Very High
cva 5 80.24 Quite High
alcohol 2 79.12 Quite High
Bile 8 76.24 Quite High
cINOD 2 75.00 Quite High
cytokine 125 72.64 Quite High
Paracetamol 2 72.12 Quite High
imagery 7 69.48 Quite High
abdominal pain 9 64.44 Quite High
Pain 9 60.24 Quite High
Disease Link Frequency Relevance Heat
Cancer 21 99.52 Very High Very High Very High
INFLAMMATION 89 99.32 Very High Very High Very High
Dengue 154 99.16 Very High Very High Very High
Dengue Hemorrhagic Fever 98 98.92 Very High Very High Very High
Liver Failure 3 98.68 Very High Very High Very High
Diarrhoea 2 98.12 Very High Very High Very High
Vomiting 8 97.60 Very High Very High Very High
Hemorrhage 43 94.36 High High
Hypertension 4 94.24 High High
Obesity 60 93.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasma aspartate aminotransferase (AST)/alanine aminotransferase (ALT) and BUN were evaluated to reflect liver and kidney function, respectively; none of these parameters were affected by OA-NO2 treatment (AST: 156.8 ± 18.4 versus 159 ± 7.7?
Positive_regulation (respectively) of Gene_expression (reflect) of AST in kidney
1) Confidence 0.49 Published 2010 Journal PPAR Research Section Body Doc Link PMC2910468 Disease Relevance 0.86 Pain Relevance 0
AST-induced NAG-1 activation was intensified when PI3K inhibitor LY294002 or Akt inhibitor was co-treated and reversed by NAG-1 siRNA transfection.
Positive_regulation (transfection) of Gene_expression (transfection) of AST
2) Confidence 0.18 Published 2009 Journal Int. J. Cancer Section Abstract Doc Link 19384947 Disease Relevance 0.37 Pain Relevance 0.14
Plasma aspartate aminotransferase (AST)/alanine aminotransferase (ALT) and BUN were evaluated to reflect liver and kidney function, respectively; none of these parameters were affected by OA-NO2 treatment (AST: 156.8 ± 18.4 versus 159 ± 7.7?
Positive_regulation (respectively) of in liver Gene_expression (reflect) of AST in kidney
3) Confidence 0.17 Published 2010 Journal PPAR Research Section Body Doc Link PMC2910468 Disease Relevance 0.86 Pain Relevance 0
The serum levels of AST and ALT were elevated slightly, but tumor markers were within normal ranges.
Positive_regulation (elevated) of Gene_expression (levels) of AST associated with cancer
4) Confidence 0.12 Published 2008 Journal World J Surg Oncol Section Abstract Doc Link PMC2614429 Disease Relevance 1.64 Pain Relevance 0.07
When we considered all dengue patients, only 22 (3%) of 644 had normal aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels (?
Positive_regulation (aspartate aminotransferase) of Gene_expression (aspartate aminotransferase) of AST associated with dengue
5) Confidence 0.07 Published 2010 Journal The American Journal of Tropical Medicine and Hygiene Section Body Doc Link PMC2946741 Disease Relevance 0.68 Pain Relevance 0.11
2.0 mg/dL, aspartate aminotransferase (AST)/alanine aminotransferase (ALT) < 3 × upper limit of normal), and kidney (serum creatinine (Crt) ?
Positive_regulation (/) of Gene_expression (/) of AST in kidney
6) Confidence 0.06 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3014873 Disease Relevance 0.41 Pain Relevance 0
One subject in the GTP arm had elevated AST and ALT levels, possibly due to concomitant medications for cold symptoms (Ibuprofen 400 mg daily for 9 days), lowering cholesterol (Lipitor 20 mg daily) and hypertension (Metoprolol 25 mg daily).
Spec (possibly) Positive_regulation (elevated) of Gene_expression (levels) of AST in arm associated with hypertension
7) Confidence 0.06 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3014873 Disease Relevance 0.49 Pain Relevance 0
Elevated levels of AST and ALT were seen in both DHF and DF patients.
Positive_regulation (Elevated) of Gene_expression (levels) of AST associated with dengue and dengue hemorrhagic fever
8) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806829 Disease Relevance 3.40 Pain Relevance 0.33
Therefore, the increase in AST and ALT levels may be due to a direct action of the venom on the liver and the heart.
Positive_regulation (increase) of Gene_expression (levels) of AST in liver
9) Confidence 0.03 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2838227 Disease Relevance 0.59 Pain Relevance 0.11

General Comments

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