INT159542

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Context Info
Confidence 0.80
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.91
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SOD2) oxidoreductase activity (SOD2) aging (SOD2)
mitochondrion organization (SOD2) DNA binding (SOD2) cytoplasm (SOD2)
Anatomy Link Frequency
smooth muscle 1
follicle 1
SOD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 12 89.76 High High
fibrosis 1 88.16 High High
pruritus 3 84.32 Quite High
metalloproteinase 2 74.80 Quite High
Bioavailability 4 69.68 Quite High
cytokine 32 55.28 Quite High
Opioid 1 51.84 Quite High
Calcitonin gene-related peptide 1 26.40 Quite Low
cINOD 36 23.96 Low Low
alcohol 12 12.16 Low Low
Disease Link Frequency Relevance Heat
Stress 120 99.76 Very High Very High Very High
Fibrosis 1 88.16 High High
Pathologic Processes 2 85.76 High High
Breast Cancer 45 85.52 High High
Pruritus 3 84.32 Quite High
Cancer 12 81.00 Quite High
Skin Diseases 1 80.56 Quite High
Adhesions 5 78.80 Quite High
Disease 19 75.84 Quite High
Malignant Neoplastic Disease 1 74.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mitochondrial localization of MnSOD is required to protect cells from ionizing radiation and other forms of oxidative damage [12].
Localization (localization) of MnSOD
1) Confidence 0.80 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468618 Disease Relevance 0.29 Pain Relevance 0.04
Other pharmacological effects of GS involve the modulation of cellular organization processes (increase of gelsolin and decrease of actin) and redox and stress responses (decrease of mitochondrial superoxide dismutase).


Localization (decrease) of mitochondrial superoxide dismutase associated with stress
2) Confidence 0.69 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945029 Disease Relevance 0.31 Pain Relevance 0
In humans, as in all mammals and most chordates, three forms of superoxide dismutase (SOD) are present: SOD1 is located in the cytoplasm, SOD2 in the mitochondria, and SOD3 is extracellular.
Localization (located) of SOD2
3) Confidence 0.60 Published 2009 Journal Acta Dermatovenerol Croat Section Abstract Doc Link 19386213 Disease Relevance 0.70 Pain Relevance 0.20
Superoxide dismutase (SOD) enzymes, Copper-Zinc SOD (Cu-Zn SOD) and Manganese superoxide dismutase (MnSoD) have been localized in the granulose and thecal cells of the growing follicle.
Localization (localized) of MnSoD in follicle
4) Confidence 0.25 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.54 Pain Relevance 0
At least three isoforms of SOD exist in mammalian tissues, namely Cu/Zn SOD (SOD1), MnSOD (SOD2) and extracellular SOD (EcSOD or SOD3) that are located in cytosol, mitochondria and vascular smooth muscle, respectively [40,41].
Localization (located) of MnSOD in smooth muscle
5) Confidence 0.10 Published 2008 Journal BMC Physiol Section Body Doc Link PMC2443377 Disease Relevance 0.07 Pain Relevance 0.12

General Comments

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