INT159543

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 29
Total Number 29
Disease Relevance 8.62
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SOD1) peroxisome (SOD1) protein complex (SOD1)
cytoplasm (SOD1) cytosol (SOD1) extracellular space (SOD1)
Anatomy Link Frequency
follicle 3
plasma 2
smooth muscle 2
endothelial cells 1
skin 1
SOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 5 96.60 Very High Very High Very High
medulla 2 95.96 Very High Very High Very High
Inflammation 71 94.16 High High
agonist 36 90.24 High High
Hippocampus 24 86.88 High High
fibrosis 1 86.32 High High
long-term potentiation 2 84.72 Quite High
pruritus 3 82.48 Quite High
Bioavailability 18 76.16 Quite High
psoriasis 63 75.60 Quite High
Disease Link Frequency Relevance Heat
Neutropenia 6 99.96 Very High Very High Very High
Leukopenia 4 99.70 Very High Very High Very High
Targeted Disruption 27 99.56 Very High Very High Very High
Anaemia 16 99.46 Very High Very High Very High
Neurodegenerative Disease 19 98.80 Very High Very High Very High
Down Syndrome 22 98.12 Very High Very High Very High
Hypertension 36 96.40 Very High Very High Very High
Disorder Of Lipid Metabolism 48 96.08 Very High Very High Very High
INFLAMMATION 79 94.16 High High
Motor Neuron Diseases 37 93.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Kaplan–Meier curves of survival for different fALS-causing SOD1 mutations, non-SOD1-related fALS, and sALS were generated.
Localization (generated) of SOD1
1) Confidence 0.75 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2486295 Disease Relevance 0.23 Pain Relevance 0.03
Preparation of SOD1-plasmid containing human serum albumin nanoparticles
Localization (Preparation) of SOD1
2) Confidence 0.74 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768759 Disease Relevance 0 Pain Relevance 0
In humans, as in all mammals and most chordates, three forms of superoxide dismutase (SOD) are present: SOD1 is located in the cytoplasm, SOD2 in the mitochondria, and SOD3 is extracellular.
Localization (located) of SOD1
3) Confidence 0.74 Published 2009 Journal Acta Dermatovenerol Croat Section Abstract Doc Link 19386213 Disease Relevance 0.68 Pain Relevance 0.14
In order to evaluate the contribution of Cu/Zn superoxide dismutase (SOD-1) in endothelial cells in response to exercise training, aortic and mesenteric expression of SOD-1 was determined by Western blotting assays.
Localization (contribution) of Cu/Zn superoxide dismutase in endothelial cells
4) Confidence 0.73 Published 2008 Journal BMC Physiol Section Body Doc Link PMC2443377 Disease Relevance 0.06 Pain Relevance 0
However, as SOD does not bind to cellular membranes and is rapidly excreted from the kidney, it has not been practically used so far [2].
Localization (excreted) of SOD in kidney
5) Confidence 0.70 Published 2008 Journal Colorectal Disease Section Body Doc Link PMC2659364 Disease Relevance 0.31 Pain Relevance 0
Cumulative release of pSOD as a percentage of encapsulated plasmid was calculated as a function of time.


Localization (release) of pSOD
6) Confidence 0.69 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768759 Disease Relevance 0 Pain Relevance 0
As shown in Figure 2C in vitro pSOD release from HSA NP with low crosslinking and a particle size of about 160 nm, is a biphasic curve including a fast-release phase, during which 65% of the drug load was released in the first 6 h, and a slow but steady release phase, accounting for the release of the remaining plasmid load in the next 44 h.
Localization (release) of pSOD
7) Confidence 0.69 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768759 Disease Relevance 0 Pain Relevance 0
In vitro release of pSOD from HSA NP was evaluated by dispersing freshly prepared NP in 1 ml of PBS containing 0.1% sodium azide followed by shaking at 37 °C, 100 rpm.
Localization (release) of pSOD
8) Confidence 0.69 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768759 Disease Relevance 0 Pain Relevance 0
A transgenic mouse overexpressing human SOD1 was created and may serve as a model for neurodegenerative disorders [9].
Localization (created) of SOD1 associated with targeted disruption and neurodegenerative disease
9) Confidence 0.65 Published 2004 Journal Proteome Sci Section Body Doc Link PMC446209 Disease Relevance 0.81 Pain Relevance 0.17
Expression of 4632432E04Rik protein (Q9D358) showed a significant decrease in both, hemizygous and homozygous SOD1-TGs (P < 0.05; P < 0.001).
Localization (decrease) of SOD1
10) Confidence 0.65 Published 2004 Journal Proteome Sci Section Body Doc Link PMC446209 Disease Relevance 0 Pain Relevance 0.04
Nuclease and vitreous liquid stability of pSOD in human serum albumin nanoparticles
Localization (Nuclease) of pSOD
11) Confidence 0.64 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768759 Disease Relevance 0 Pain Relevance 0
Endolysosomal escape of pSOD-human serum albumin nanoparticles
Localization (escape) of pSOD
12) Confidence 0.64 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768759 Disease Relevance 0 Pain Relevance 0
At predetermined time intervals, the particle suspension was spun down at 48,000x g, 4 °C for 50 min. pSOD released in the supernatant was quantified using Hoechst assay.
Localization (released) of pSOD
13) Confidence 0.64 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768759 Disease Relevance 0 Pain Relevance 0
Encapsulation efficiency(%)=(Plasmid used-unencapsulated plasmid)x100/Plasmid used

In vitro release of pSOD-human serum albumin nanoparticles

Localization (release) of pSOD
14) Confidence 0.64 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768759 Disease Relevance 0 Pain Relevance 0
Preparation of pSOD-encapsulated human serum albumin nanoparticles
Localization (Preparation) of pSOD
15) Confidence 0.64 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768759 Disease Relevance 0.13 Pain Relevance 0
Preparation of pSOD-EYFP plasmid
Localization (Preparation) of pSOD
16) Confidence 0.64 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768759 Disease Relevance 0.16 Pain Relevance 0.04
Superoxide dismutase (SOD) enzymes, Copper-Zinc SOD (Cu-Zn SOD) and Manganese superoxide dismutase (MnSoD) have been localized in the granulose and thecal cells of the growing follicle.
Localization (localized) of SOD in follicle
17) Confidence 0.36 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.56 Pain Relevance 0
Superoxide dismutase (SOD) enzymes, Copper-Zinc SOD (Cu-Zn SOD) and Manganese superoxide dismutase (MnSoD) have been localized in the granulose and thecal cells of the growing follicle.
Localization (localized) of SOD in follicle
18) Confidence 0.34 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.55 Pain Relevance 0
This decrease may be associated with a decrease in NO levels, reinforcing that SOD is helpful in the release of NO [46, 47].
Localization (release) of SOD
19) Confidence 0.33 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2127225 Disease Relevance 0.40 Pain Relevance 0.04
Superoxide dismutase (SOD) enzymes, Copper-Zinc SOD (Cu-Zn SOD) and Manganese superoxide dismutase (MnSoD) have been localized in the granulose and thecal cells of the growing follicle.
Localization (localized) of SOD in follicle
20) Confidence 0.28 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.55 Pain Relevance 0

General Comments

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