INT159547

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.74
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pilra)
Anatomy Link Frequency
vesicles 1
DRG 1
Pilra (Mus musculus)
Pain Link Frequency Relevance Heat
Hyperalgesia 5 99.70 Very High Very High Very High
Sciatic nerve 1 92.84 High High
agonist 3 81.56 Quite High
Inflammation 3 78.12 Quite High
Intracerebroventricular 1 72.20 Quite High
IPN 1 64.88 Quite High
Central nervous system 3 64.52 Quite High
Analgesic 4 61.40 Quite High
COX2 1 25.00 Low Low
Opioid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperalgesia 6 99.70 Very High Very High Very High
INFLAMMATION 3 78.12 Quite High
Cancer 1 59.88 Quite High
Bacillus Anthracis Infection 3 5.00 Very Low Very Low Very Low
Infection 3 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Vesicular Stomatitis 1 5.00 Very Low Very Low Very Low
Inflammatory Pain 1 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate the mechanism by which PEA attenuated hyperalgesia, we evaluated inhibitory kB-alpha (IkB-alpha) degradation and p65 nuclear factor kB (NF-kappaB) activation in DRG.
Protein_catabolism (degradation) of inhibitory kB-alpha in DRG associated with hyperalgesia
1) Confidence 0.14 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19386271 Disease Relevance 0.68 Pain Relevance 0.90
We find that the small protein SNX3, which binds the signaling lipid phosphatidyl inositol-3-phosphate, is necessary for the formation of intralumenal vesicles, but is not involved in the degradation of the cell surface receptor for EGF.
Protein_catabolism (degradation) of cell surface receptor in vesicles
2) Confidence 0.01 Published 2008 Journal PLoS Biology Section Abstract Doc Link PMC2528051 Disease Relevance 0.06 Pain Relevance 0

General Comments

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