INT159570

Context Info Confidence 0.34 First Reported 2009 Last Reported 2009 Negated 0 Speculated 1 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.27 Pain Relevance 0.31

nucleus (Alox5, Fos) nuclear envelope (Alox5) aging (Fos) DNA binding (Fos) response to stress (Fos) cytoplasm (Alox5)

Anatomy Link Frequency spinal cord 3 Alox5 (Rattus norvegicus) Fos (Rattus norvegicus)

Pain Link Frequency Relevance Heat Pain 3 99.52 Spinal cord 1 98.76 Inflammation 5 93.68 spinal dorsal horn 1 77.28 IPN 2 75.00 antagonist 1 25.00

Disease Link Frequency Relevance Heat Pain 1 99.52 INFLAMMATION 2 93.68 Inflammatory Pain 2 75.00 Hyperalgesia 1 38.96 Nociception 2 30.64 Hypersensitivity 1 25.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, it is unclear whether the inhibition of the LO activity regulates the expression of c-Fos protein, a pain marker in the spinal cord.

Spec (209) Negative_regulation (inhibition) of LO in spinal cord Spec (whether) Regulation (regulates) of Gene_expression (expression) of Fos in spinal cord associated with pain and spinal cord

1) Confidence 0.34 Published 2009 Journal Mol. Cells Section Abstract Doc Link 19390822 Disease Relevance 0.27 Pain Relevance 0.31

General Comments

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