INT159571

Context Info Confidence 0.37 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.58 Pain Relevance 0.40

cytosol (Trpv1, Alox5) nuclear envelope (Alox5) oxidoreductase activity (Alox5) nucleus (Alox5) plasma membrane (Trpv1) cytoplasm (Alox5)

Trpv1 (Rattus norvegicus) Alox5 (Rattus norvegicus)

Pain Link Frequency Relevance Heat antagonist 1 98.52 Inflammation 5 77.92 spinal dorsal horn 1 75.64 IPN 2 75.00 Spinal cord 1 65.24 Pain 3 64.20

Disease Link Frequency Relevance Heat Nociception 2 98.68 Hypersensitivity 1 96.28 Hyperalgesia 1 94.56 Inflammatory Pain 2 75.00 INFLAMMATION 2 67.20 Pain 1 64.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

LO products are endogenous TRPV1 activators and pretreatment with BCTC, a TRPV1 antagonist inhibited the thermal but not the mechanical hypersensitivity.

TRPV1 Positive_regulation (activators) of Gene_expression (products) of LO associated with antagonist and hypersensitivity

1) Confidence 0.37 Published 2009 Journal Mol. Cells Section Abstract Doc Link 19390822 Disease Relevance 0.58 Pain Relevance 0.40

General Comments

This test has worked.