INT159593

Context Info Confidence 0.38 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Title Documents 1 Total Number 1 Disease Relevance 0.46 Pain Relevance 0.74

cytoplasm (Nfkb1, Nos2) cytosol (Nfkb1, Nos2) signal transduction (Nfkb1, Nos2) nucleus (Nfkb1, Nos2) mitochondrion (Nfkb1) peroxisome (Nos2)

Nfkb1 (Mus musculus) Nos2 (Mus musculus)

Pain Link Frequency Relevance Heat COX2 2 98.32 cOX1 2 98.32 Inflammation 3 96.92 Analgesic 3 96.36 Rheumatism 1 92.12 Earache 1 91.24

Disease Link Frequency Relevance Heat INFLAMMATION 3 96.92 Rheumatic Diseases 1 92.12 Fever 1 91.64 Earache 1 91.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Cardiospermum halicacabum ethanol extract inhibits LPS induced COX-2, TNF-alpha and iNOS expression, which is mediated by NF-kappaB regulation, in RAW264.7 cells.

Regulation (regulation) of NF-kappaB Positive_regulation (mediated) of Gene_expression (expression) of iNOS associated with cox1

1) Confidence 0.38 Published 2009 Journal J Ethnopharmacol Section Title Doc Link 19393729 Disease Relevance 0.46 Pain Relevance 0.74

General Comments

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