INT159598

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Context Info
Confidence 0.48
First Reported 2007
Last Reported 2011
Negated 0
Speculated 5
Reported most in Body
Documents 3
Total Number 12
Disease Relevance 1.84
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL18) extracellular space (IL18) extracellular region (IL18)
cell-cell signaling (IL18) cytoplasm (IL18)
Anatomy Link Frequency
macrophage 2
IL18 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 4 100.00 Very High Very High Very High
cytokine 158 98.36 Very High Very High Very High
Dismenorea 12 97.48 Very High Very High Very High
rheumatoid arthritis 87 86.08 High High
alcohol 10 43.84 Quite Low
Inflammation 91 42.52 Quite Low
chemokine 12 35.24 Quite Low
Arthritis 30 21.84 Low Low
imagery 10 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dysmenorrhea 12 97.48 Very High Very High Very High
Rheumatoid Arthritis 87 86.08 High High
Disease 20 79.16 Quite High
Cancer 21 69.20 Quite High
Necrosis 21 68.72 Quite High
Autoimmune Disease 1 54.84 Quite High
INFLAMMATION 93 42.52 Quite Low
Arthritis 23 21.84 Low Low
Apoptosis 32 13.04 Low Low
Herpes Simplex Virus 1 5.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: To investigate the eutopic endometrial interleukin-18 (IL-18) system including interleukin-18 (IL-18), IL-18 receptor (IL-18R), and IL-18 binding protein (IL-18BP), mRNA, and protein expression in patients with adenomyosis.
Spec (investigate) Positive_regulation (endometrial) of Spec (investigate) Transcription (system) of IL-18 associated with dismenorea
1) Confidence 0.48 Published 2010 Journal Fertil. Steril. Section Abstract Doc Link 19394601 Disease Relevance 0.17 Pain Relevance 0.17
OBJECTIVE: To investigate the eutopic endometrial interleukin-18 (IL-18) system including interleukin-18 (IL-18), IL-18 receptor (IL-18R), and IL-18 binding protein (IL-18BP), mRNA, and protein expression in patients with adenomyosis.
Spec (investigate) Positive_regulation (endometrial) of Spec (investigate) Transcription (system) of IL-18 associated with dismenorea
2) Confidence 0.48 Published 2010 Journal Fertil. Steril. Section Abstract Doc Link 19394601 Disease Relevance 0.17 Pain Relevance 0.17
OBJECTIVE: To investigate the eutopic endometrial interleukin-18 (IL-18) system including interleukin-18 (IL-18), IL-18 receptor (IL-18R), and IL-18 binding protein (IL-18BP), mRNA, and protein expression in patients with adenomyosis.
Spec (investigate) Positive_regulation (endometrial) of Spec (investigate) Transcription (system) of IL-18 associated with dismenorea
3) Confidence 0.48 Published 2010 Journal Fertil. Steril. Section Abstract Doc Link 19394601 Disease Relevance 0.17 Pain Relevance 0.17
OBJECTIVE: To investigate the eutopic endometrial interleukin-18 (IL-18) system including interleukin-18 (IL-18), IL-18 receptor (IL-18R), and IL-18 binding protein (IL-18BP), mRNA, and protein expression in patients with adenomyosis.
Spec (investigate) Positive_regulation (endometrial) of Spec (investigate) Transcription (system) of interleukin-18 associated with dismenorea
4) Confidence 0.48 Published 2010 Journal Fertil. Steril. Section Abstract Doc Link 19394601 Disease Relevance 0.17 Pain Relevance 0.17
OBJECTIVE: To investigate the eutopic endometrial interleukin-18 (IL-18) system including interleukin-18 (IL-18), IL-18 receptor (IL-18R), and IL-18 binding protein (IL-18BP), mRNA, and protein expression in patients with adenomyosis.
Spec (investigate) Positive_regulation (endometrial) of Spec (investigate) Transcription (system) of interleukin-18 associated with dismenorea
5) Confidence 0.48 Published 2010 Journal Fertil. Steril. Section Abstract Doc Link 19394601 Disease Relevance 0.17 Pain Relevance 0.17
Quantitative competitive PCR demonstrated that endometrial IL-18R mRNA and the ratio of IL-18BP to IL-18 were significantly increased in adenomyosis patients in comparison to the control group.
Positive_regulation (increased) of Transcription (ratio) of IL-18
6) Confidence 0.48 Published 2010 Journal Fertil. Steril. Section Body Doc Link 19394601 Disease Relevance 0.06 Pain Relevance 0
As we previously reported that high IL-18/TWEAK endometrial mRNA expression correlated with a significant increase of uNK cells recruitment, we investigated the role of these two cytokines on uNK cells cytotoxicity.
Positive_regulation (high) of Transcription (expression) of IL-18 associated with cytokine
7) Confidence 0.45 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0 Pain Relevance 0.10
As we previously reported that high IL-18/TWEAK endometrial mRNA expression correlated with a significant increase of uNK cells recruitment, we investigated the role of these two cytokines on uNK cells cytotoxicity.
Positive_regulation (endometrial) of Transcription (expression) of IL-18 associated with cytokine
8) Confidence 0.45 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0 Pain Relevance 0.10
We retrospectively selected endometrial samples with a high IL-18 mRNA expression (over 6.17) and low (below 4.1) or high TWEAK (over 6.86) mRNA expression to compare their NKp46 and TGF-?
Positive_regulation (over) of Transcription (expression) of IL-18
9) Confidence 0.45 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0 Pain Relevance 0
As we previously reported that high IL-18/TWEAK endometrial mRNA expression correlated with a significant increase of uNK cells recruitment, we investigated the role of these two cytokines on uNK cells cytotoxicity.
Positive_regulation (/) of Transcription (expression) of IL-18 associated with cytokine
10) Confidence 0.45 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0 Pain Relevance 0.10
We retrospectively selected endometrial samples with a high IL-18 mRNA expression (over 6.17) and low (below 4.1) or high TWEAK (over 6.86) mRNA expression to compare their NKp46 and TGF-?
Positive_regulation (high) of Transcription (expression) of IL-18
11) Confidence 0.45 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0 Pain Relevance 0
AP-1 = activator protein-1; CRP = C-reactive protein; GM-CSF = granulocyte macrophage colony-stimulating factor; IFN = interferon; IL = interleukin; IL-1RA = interleukin-1 receptor antagonist; LPS = lipopolysaccharide; M?
Positive_regulation (lipopolysaccharide) of Transcription (antagonist) of interleukin-1 in macrophage associated with antagonist
12) Confidence 0.08 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246244 Disease Relevance 0.92 Pain Relevance 0.18

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