INT1596

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Context Info
Confidence 0.57
First Reported 1979
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 61
Total Number 62
Disease Relevance 13.50
Pain Relevance 38.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprl1) plasma membrane (Oprl1) signal transducer activity (Oprl1)
Anatomy Link Frequency
heart 4
NG108-15 3
plasma 2
macrophages 1
ileum 1
Oprl1 (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 193 100.00 Very High Very High Very High
opiate 162 100.00 Very High Very High Very High
orphanin 84 100.00 Very High Very High Very High
antagonist 41 100.00 Very High Very High Very High
Kappa opioid receptor 16 100.00 Very High Very High Very High
ketamine 13 100.00 Very High Very High Very High
Dopamine 7 99.90 Very High Very High Very High
agonist 74 99.82 Very High Very High Very High
withdrawal 8 99.60 Very High Very High Very High
Dynorphin 6 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 17 99.96 Very High Very High Very High
Neuroblastoma 16 99.84 Very High Very High Very High
Hemorrhagic Shock 8 99.68 Very High Very High Very High
Hypotension 6 99.62 Very High Very High Very High
Glioma 7 99.20 Very High Very High Very High
Eating Disorder 18 98.68 Very High Very High Very High
Cv General 4 Under Development 18 98.64 Very High Very High Very High
Nociception 17 98.48 Very High Very High Very High
Hyperalgesia 10 98.24 Very High Very High Very High
Pain 10 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results show that the loss of the nociceptin receptor results in a gain-of-function mutation in both the memory process and the long-term potentiation mechanism in CA1, perhaps as a result of altered intracellular signal transduction systems in neurons.
Negative_regulation (loss) of nociceptin receptor in neurons associated with orphanin and long-term potentiation
1) Confidence 0.57 Published 1998 Journal Nature Section Abstract Doc Link 9707118 Disease Relevance 0.21 Pain Relevance 0.65
Central opiate receptor blockade was induced by 10 micrograms/kg intracerebroventricularly (i.c.v.) injected naloxone at the 60th min of the bleeding period.
Negative_regulation (blockade) of opiate receptor associated with narcan, hemorrhage and opiate
2) Confidence 0.45 Published 1997 Journal Shock Section Abstract Doc Link 9110415 Disease Relevance 0.43 Pain Relevance 0.65
To study whether the effects of opiate receptor inhibition are mediated by means of an action on the central opiate system, we administered equimolar doses of naloxone hydrochloride and naloxone methobromide (MeBr) and normal saline to heart failure dogs.
Spec (whether) Negative_regulation (inhibition) of opiate receptor in heart associated with cv general 4 under development, narcan and opiate
3) Confidence 0.44 Published 1989 Journal Circ. Res. Section Abstract Doc Link 2544317 Disease Relevance 0.35 Pain Relevance 0.60
Duration of opiate receptor blockade determines tumorigenic response in mice with neuroblastoma: a role for endogenous opioid systems in cancer.
Negative_regulation (blockade) of opiate receptor associated with neuroblastoma, cancer, narcan, endogenous opioid and opiate
4) Confidence 0.43 Published 1984 Journal Life Sci. Section Title Doc Link 6087062 Disease Relevance 0.95 Pain Relevance 0.83
Mice lacking the ORL1 receptor showed no significant differences in nociceptive threshold compared with wild mice.
Negative_regulation (lacking) of ORL1 receptor associated with nociception
5) Confidence 0.43 Published 1999 Journal Prog. Neurobiol. Section Abstract Doc Link 10215100 Disease Relevance 0.49 Pain Relevance 1.58
Both sleep times and burst suppression activity were significantly reduced with a selective ORL1 antagonist.
Negative_regulation (reduced) of ORL1
6) Confidence 0.43 Published 2007 Journal Anesth. Analg. Section Body Doc Link 17179266 Disease Relevance 0.07 Pain Relevance 0
[Behavioral pharmacological characterization of mice lacking the nociceptin receptor].
Negative_regulation (lacking) of nociceptin receptor associated with orphanin and narcan
7) Confidence 0.42 Published 1999 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Title Doc Link 10464778 Disease Relevance 0.56 Pain Relevance 1.01
Here, we report the behavioral pharmacological characterization of mice lacking the nociceptin receptor.
Negative_regulation (lacking) of nociceptin receptor associated with orphanin
8) Confidence 0.42 Published 1999 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 10464778 Disease Relevance 0.50 Pain Relevance 0.74
Here we show that mice lacking the nociceptin receptor possess greater learning ability and have better memory than control mice.
Negative_regulation (lacking) of nociceptin receptor associated with orphanin
9) Confidence 0.42 Published 1998 Journal Nature Section Abstract Doc Link 9707118 Disease Relevance 0.27 Pain Relevance 0.69
Molecular mechanisms of agonist-induced desensitization of the cloned mouse kappa opioid receptor.
Negative_regulation (desensitization) of kappa opioid receptor associated with analgesic, kappa opioid receptor and agonist
10) Confidence 0.42 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 7932192 Disease Relevance 0 Pain Relevance 0.97
The reduction in affinity of the kappa receptor for agonists is dependent on the time of agonist exposure and is reversible.
Negative_regulation (reduction) of kappa receptor associated with agonist
11) Confidence 0.41 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932192 Disease Relevance 0 Pain Relevance 0.97
The desensitization of the kappa receptor is dependent on the time and concentration of agonist treatment, is blocked by the kappa-selective antagonist nor-binaltorphimine and is reversible.
Negative_regulation (desensitization) of kappa receptor associated with antagonist and agonist
12) Confidence 0.41 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932192 Disease Relevance 0 Pain Relevance 0.77
Implications: This study shows that opiate receptor block paradoxically inhibits sensitivity to heat-pain in inflamed skin during body cooling.
Negative_regulation (block) of opiate receptor in body associated with pain and opiate
13) Confidence 0.41 Published 2000 Journal Anesth. Analg. Section Abstract Doc Link 10735800 Disease Relevance 0.59 Pain Relevance 1.49
In deep hemorrhagic hypotension, however, general opiate receptor blockade resulted not only in a further reduction of the already impaired CO(2)-sensitivity, but even in a reversal of the effect of CO(2) from flow increase to flow decrease.
Negative_regulation (blockade) of opiate receptor associated with hypotension and opiate
14) Confidence 0.41 Published 2003 Journal Brain Res. Bull. Section Abstract Doc Link 12576139 Disease Relevance 0.68 Pain Relevance 0.83
Fluorination produces only a twofold opiate receptor affinity loss when measured either by bioassay or receptor binding (selectivity mu congruent to delta greater than kappa).
Negative_regulation (loss) of opiate receptor associated with opiate
15) Confidence 0.41 Published 1983 Journal J. Med. Chem. Section Abstract Doc Link 6313921 Disease Relevance 0 Pain Relevance 0.39
The ability of MEAP to interrupt the vagal control of heart rate and contractile activity involves opiate receptors since the effect was eliminated in both cases by prior opiate receptor blockade with the high affinity antagonist, diprenorphine.
Negative_regulation (blockade) of opiate receptor in heart associated with antagonist and opiate
16) Confidence 0.40 Published 1999 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 10412830 Disease Relevance 0.05 Pain Relevance 0.60
Each of them, however, was less potent than the comparable 3-hydroxy analogue, and their binding affinity to the opiate receptor was substantially decreased.
Negative_regulation (decreased) of opiate receptor associated with opiate
17) Confidence 0.40 Published 1979 Journal J. Med. Chem. Section Abstract Doc Link 218012 Disease Relevance 0 Pain Relevance 0.58
This study demonstrates a region-specific loss of mu-opiate receptor labelling following long-term deprivation of gonadal steroids, and supports the hypothesis that estrogen directly or indirectly influences the density of mu-opioid receptors in the rostral forebrain of female mice.
Negative_regulation (loss) of mu-opiate receptor in gonadal associated with mu opioid receptor and opiate
18) Confidence 0.40 Published 1993 Journal Brain Res. Bull. Section Abstract Doc Link 8384520 Disease Relevance 0 Pain Relevance 0.21
Despite the low proportion of macrophages among total splenocytes (about 10%), our results also indicate a tendency to a reduction in opiate receptor density also in the macrophage population.
Negative_regulation (reduction) of opiate receptor in macrophages associated with opiate
19) Confidence 0.38 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8858990 Disease Relevance 0 Pain Relevance 1.49
In vitro inhibition of esterases by paraoxon reduced the affinity of heroin for the opiate receptor, while that of morphine was unaffected.
Negative_regulation (reduced) of opiate receptor associated with opiate and morphine
20) Confidence 0.38 Published 1986 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 3003965 Disease Relevance 0 Pain Relevance 0.30

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