INT159613

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Context Info
Confidence 0.57
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.31
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpm3)
Anatomy Link Frequency
cerebrum 1
choroid plexus 1
brain 1
kidney 1
Trpm3 (Mus musculus)
Pain Link Frequency Relevance Heat
TRP channel 181 100.00 Very High Very High Very High
Mechanosensation 1 86.84 High High
agonist 21 77.56 Quite High
member 8 2 44.64 Quite Low
qutenza 5 39.28 Quite Low
addiction 6 17.12 Low Low
Central nervous system 28 5.00 Very Low Very Low Very Low
fibrosis 24 5.00 Very Low Very Low Very Low
Serotonin 9 5.00 Very Low Very Low Very Low
adenocard 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 1 99.52 Very High Very High Very High
Skin Cancer 4 99.00 Very High Very High Very High
Metastasis 1 98.94 Very High Very High Very High
Melanoma 8 96.00 Very High Very High Very High
Nevus 8 95.12 Very High Very High Very High
Loss Of Sense Of Smell 4 87.12 High High
Sprains And Strains 51 86.00 High High
Coronary Heart Disease 6 14.52 Low Low
Targeted Disruption 18 12.84 Low Low
Cystic Fibrosis 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to humans where TRPM3 shows a high expression in kidney [17], mouse kidney did not reveal extensive expression of TRPM3.
Gene_expression (expression) of TRPM3 in kidney
1) Confidence 0.57 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0 Pain Relevance 0
The very high expression of TRPM3 and M7 in cerebrum of C57Bl/10 mice was not observed in NOD and Balb/c.
Gene_expression (expression) of TRPM3 in cerebrum
2) Confidence 0.44 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0.52 Pain Relevance 0.06
Both sets of data show high expression most TRPC members, TRPM3, 4 and 7, followed by TRPV2, 4 and 6.
Gene_expression (expression) of TRPM3
3) Confidence 0.39 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0 Pain Relevance 0.08
By contrast, in situ hybridisation methods were used to demonstrate the expression mRNA encoding TRPM3 in the lateral and third ventricle choroid plexus of mouse brain (see Figure 7) [101].
Gene_expression (expression) of TRPM3 in brain
4) Confidence 0.26 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2072944 Disease Relevance 0 Pain Relevance 0.13
These data suggest that the conductance may be carried by TRPM3 or TRPV4 channels.


4 Unconventional ion channels

Gene_expression (carried) of TRPM3
5) Confidence 0.23 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2072944 Disease Relevance 0 Pain Relevance 0.03
Recent molecular evidence indicates that choroid plexus also expresses the non-selective cation channels such as transient receptor potential channels (TRPV4 and TRPM3) and purinoceptor type 2 (P2X) receptor operated channels.
Gene_expression (expresses) of TRPM3 in choroid plexus associated with trp channel
6) Confidence 0.20 Published 2007 Journal Cerebrospinal Fluid Res Section Abstract Doc Link PMC2072944 Disease Relevance 0 Pain Relevance 0.05
In the OE, TRPC1 and 6, TRPM3, 4, 5, 6, and 7, TRPV2 and 6, and TRPA1 have been shown to be expressed by RT-PCR [4].
Gene_expression (expressed) of TRPM3
7) Confidence 0.18 Published 2010 Journal Acta Oto-Laryngologica Section Body Doc Link PMC2981077 Disease Relevance 0.09 Pain Relevance 0.16
Of the 16 patients who experienced metastasis, 15 (94%) had primary tumors that displayed reduced MLSN mRNA expression by all or a part of the dermal tumor.
Gene_expression (expression) of MLSN mRNA associated with cancer, skin cancer and metastasis
8) Confidence 0.00 Published 2009 Journal Mod. Pathol. Section Abstract Doc Link 19396153 Disease Relevance 1.71 Pain Relevance 0

General Comments

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