INT159614

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Context Info
Confidence 0.77
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 29
Disease Relevance 9.47
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpm1) plasma membrane (Trpm1) molecular_function (Trpm1)
cellular_component (Trpm1) transmembrane transport (Trpm1)
Anatomy Link Frequency
retina 3
rod bipolar cell 2
dendrites 1
horizontal cells 1
glial cells 1
Trpm1 (Mus musculus)
Trpm1 - F1075S (2)
Pain Link Frequency Relevance Heat
member 8 84 100.00 Very High Very High Very High
ketamine 17 77.60 Quite High
Kinase C 16 69.04 Quite High
Glutamate receptor 59 66.04 Quite High
gABA 8 58.12 Quite High
Glutamate 25 5.00 Very Low Very Low Very Low
Spinal cord 8 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
dorsal root ganglion 8 5.00 Very Low Very Low Very Low
Neurotransmitter 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 33 99.68 Very High Very High Very High
Nevus 32 99.60 Very High Very High Very High
Night Blindness 748 99.48 Very High Very High Very High
Melanoma 32 98.92 Very High Very High Very High
Ganglion Cysts 112 97.72 Very High Very High Very High
Death 24 92.64 High High
Adhesions 24 90.16 High High
Apoptosis 8 88.92 High High
Myopia 136 88.88 High High
Congenital Anomalies 68 88.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our previous expression analysis of mouse TRPM1 showed that the long form (TRPM1-L), which functions as a cation channel, is predominantly expressed in the retina [11], suggesting that human patient samples for directly analyzing splicing are not readily available.
Gene_expression (expressed) of TRPM1 in retina
1) Confidence 0.77 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838739 Disease Relevance 0 Pain Relevance 0
Trpm1 is alternatively spliced, resulting in the production of a long form protein (trpm1-L) and a short N-terminal form devoid of transmembrane segments (trpm1-S).
Gene_expression (production) of trpm1-L
2) Confidence 0.77 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838739 Disease Relevance 0.54 Pain Relevance 0.22
We examined the localization of the expressed TRPM1 mutant proteins in ON BCs at P14 when the endogenous mouse TRPM1 is preferentially localized to the dendritic tips [11,19].
Gene_expression (expressed) of TRPM1
3) Confidence 0.77 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838739 Disease Relevance 0 Pain Relevance 0
Our previous expression analysis of mouse TRPM1 showed that the long form (TRPM1-L), which functions as a cation channel, is predominantly expressed in the retina [11], suggesting that human patient samples for directly analyzing splicing are not readily available.
Gene_expression (expressed) of TRPM1-L in retina
4) Confidence 0.77 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838739 Disease Relevance 0 Pain Relevance 0
Trpm1 expression was seen in a subset of bipolar cells (Fig. 2I).
Gene_expression (expression) of Trpm1
5) Confidence 0.72 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2665264 Disease Relevance 0.42 Pain Relevance 0
Additionally, Nfasc and Trpm1 are expressed in a minority of cells expressing the rod bipolar cell-enriched gene Pcp2, which could reflect gene expression heterogeneity in these cells.
Gene_expression (expressed) of Trpm1 in rod bipolar cell
6) Confidence 0.72 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2665264 Disease Relevance 0.18 Pain Relevance 0.03
Trpm1-positive cells were almost all labeled with the Chx10 probe, but only a minority of cells was positive for Pcp2 or Grm6, suggesting that Trpm1 is expressed in cone OFF bipolar cells and in a small number of cone ON bipolar cells and rod bipolar cells. 6330514A18Rik is expressed in bipolar cells and photoreceptor cells, and from the double-labeling experiments, it was found in a small minority of Pcp2-positive cells and in at least some Grm6-positive cells.
Gene_expression (expressed) of Trpm1 in rod bipolar cells
7) Confidence 0.72 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2665264 Disease Relevance 0.17 Pain Relevance 0
We then prepared expression vectors of R624C- and F1075S-TRPM1 cDNAs fused with the mouse mGluR6 9.5 kb promoter that drives ON BC-specific expression (Figure 3A).
Gene_expression (expression) of TRPM1 (F1075S)
8) Confidence 0.67 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838739 Disease Relevance 0 Pain Relevance 0
Clinical characteristics of the complete CSNB patients associated with TRPM1 mutations
Gene_expression (mutations) of TRPM1 associated with night blindness
9) Confidence 0.67 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838739 Disease Relevance 0.69 Pain Relevance 0
ERG recordings in the trpm1 null mutant (trpm1–/–) mice
Gene_expression (null) of trpm1
10) Confidence 0.67 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838739 Disease Relevance 0 Pain Relevance 0.04
ERG analysis of the trpm1 null mutant (trpm1–/–) mice
Gene_expression (null) of trpm1
11) Confidence 0.67 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838739 Disease Relevance 0.34 Pain Relevance 0
-actin gene (CAG) promoter region in CAG-TRPM1 was replaced with the 9.5 kb fragment of mGluR6 5?
Gene_expression (replaced) of TRPM1
12) Confidence 0.67 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838739 Disease Relevance 0 Pain Relevance 0
These results in human and mice strongly indicated that TRPM1 is essential for the function of ON BCs in the visual pathway.
Gene_expression (essential) of TRPM1
13) Confidence 0.67 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838739 Disease Relevance 0.54 Pain Relevance 0
Analysis of protein expression from TRPM1 mutant minigenes
Gene_expression (expression) of TRPM1
14) Confidence 0.67 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838739 Disease Relevance 0 Pain Relevance 0
Clinical evaluations in patients associated with TRPM1 mutations
Gene_expression (mutations) of TRPM1
15) Confidence 0.67 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838739 Disease Relevance 0 Pain Relevance 0
To determine the functional relevance of R624C and F1075S TRPM1 residues, we mutagenized the TRPM1 cDNA to introduce R624C and F1075S mutations.
Gene_expression (residues) of TRPM1 (F1075S)
16) Confidence 0.67 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838739 Disease Relevance 0 Pain Relevance 0
Cells positive for Calb expression were negative for Og9x (0/11), Scgn (0/15), Cntn4 (0/15), Car8 (0/15), 2300002D11Rik (0/14), and Trpm1 (0/16) expression (Fig. 3, Supplementary Fig. 1).
Gene_expression (expression) of Trpm1
17) Confidence 0.63 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2665264 Disease Relevance 0.09 Pain Relevance 0
Only a small minority of Glul-positive cells was positive with probes for Og9x, Scgn, Cntn4, Car8, 2300002D11Rik, Nfasc, or Trpm1, suggesting that these genes are not found in Müller glial cells at high frequency (Fig. 3, Supplementary Fig. 1, Supplementary Table 1).
Gene_expression (probes) of Trpm1 in glial cells
18) Confidence 0.62 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2665264 Disease Relevance 0.13 Pain Relevance 0
Only a small minority of Pax6-positive cells was positive with probes for Og9x, Scgn, Car8, 2300002D11Rik, or Trpm1, suggesting that these genes are not found in amacrine, ganglion, or horizontal cells at high frequency (Fig. 3, Supplementary Fig. 1, Supplementary Table 2).
Gene_expression (probes) of Trpm1 in horizontal cells associated with ganglion cysts
19) Confidence 0.62 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2665264 Disease Relevance 0.23 Pain Relevance 0
However, it should be noted that there is also a possibility that the transfected TRPM1 proteins are misfolded due to the addition of the 3xFlag tag, leading to the undetectability of Flag-tagged mutant proteins specifically in the dendrites.
Gene_expression (transfected) of TRPM1 in dendrites
20) Confidence 0.60 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838739 Disease Relevance 0.27 Pain Relevance 0

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