INT159618

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Context Info
Confidence 0.69
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 10
Disease Relevance 11.42
Pain Relevance 1.21

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transport (Trpm1) plasma membrane (Trpm1) molecular_function (Trpm1)
cellular_component (Trpm1) transmembrane transport (Trpm1)
Trpm1 (Mus musculus)
Trpm1 - R624C (1)
Pain Link Frequency Relevance Heat
member 8 24 98.32 Very High Very High Very High
Glutamate receptor 6 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nevus 64 99.60 Very High Very High Very High
Melanoma 64 99.54 Very High Very High Very High
Skin Cancer 34 98.88 Very High Very High Very High
Metastasis 8 91.12 High High
Cancer 8 88.48 High High
Night Blindness 88 5.00 Very Low Very Low Very Low
Myopia 16 5.00 Very Low Very Low Very Low
Congenital Anomalies 8 5.00 Very Low Very Low Very Low
Refractive Errors 4 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Wild-type (WT) and mutant forms of TRPM1 (R624C and F1075S) containing 3× Flag at the C-terminus were expressed from the mouse mGluR6 promoter (mGluR6-TRPM1–3×Flag).
Transcription (expressed) of TRPM1 (R624C)
1) Confidence 0.69 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838739 Disease Relevance 0 Pain Relevance 0
Wild-type (WT) and mutant forms of TRPM1 (R624C and F1075S) containing 3× Flag at the C-terminus were expressed from the mouse mGluR6 promoter (mGluR6-TRPM1–3×Flag).
Transcription (expressed) of TRPM1
2) Confidence 0.69 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838739 Disease Relevance 0 Pain Relevance 0
We analyzed a series of spindled and epithelioid cell nevi (Spitz) and primary cutaneous nodular melanomas to determine whether the expression of TRPM1 mRNA may be useful in distinguishing between Spitz nevi and nodular melanomas and to further examine the patterns of TRPM1 mRNA expression in cutaneous melanocytic proliferations.
Transcription (expression) of TRPM1 associated with melanoma and nevus
3) Confidence 0.52 Published 2009 Journal Mod. Pathol. Section Abstract Doc Link 19396153 Disease Relevance 1.19 Pain Relevance 0.17
Regional loss of the TRPM1 mRNA expression by a significant subset of dermal tumor cells or a complete absence of TRPM1 expression by the dermal tumor was identified in 27 of 33 (82%) nodular melanomas, but only 1 of 95 (1%) Spitz nevi.
Transcription (expression) of TRPM1 associated with melanoma, nevus and skin cancer
4) Confidence 0.52 Published 2009 Journal Mod. Pathol. Section Abstract Doc Link 19396153 Disease Relevance 1.74 Pain Relevance 0.13
Formalin-fixed, paraffin-embedded tissues from 95 Spitz nevi and 33 nodular melanomas were analyzed for the expression of TRPM1 mRNA by in situ hybridization using (35)S-labeled riboprobes.
Spec (analyzed) Transcription (expression) of TRPM1 associated with melanoma and nevus
5) Confidence 0.52 Published 2009 Journal Mod. Pathol. Section Abstract Doc Link 19396153 Disease Relevance 1.36 Pain Relevance 0.15
We analyzed a series of spindled and epithelioid cell nevi (Spitz) and primary cutaneous nodular melanomas to determine whether the expression of TRPM1 mRNA may be useful in distinguishing between Spitz nevi and nodular melanomas and to further examine the patterns of TRPM1 mRNA expression in cutaneous melanocytic proliferations.
Transcription (expression) of TRPM1 associated with melanoma and nevus
6) Confidence 0.52 Published 2009 Journal Mod. Pathol. Section Abstract Doc Link 19396153 Disease Relevance 1.03 Pain Relevance 0.18
These findings suggest that the pattern of TRPM1 mRNA expression may be helpful in the differentiation of Spitz nevi and nodular melanomas.
Transcription (expression) of TRPM1 associated with melanoma and nevus
7) Confidence 0.52 Published 2009 Journal Mod. Pathol. Section Abstract Doc Link 19396153 Disease Relevance 1.71 Pain Relevance 0.10
TRPM1 (Melastatin-1/MLSN1) mRNA expression in Spitz nevi and nodular melanomas.
Transcription (expression) of TRPM1 associated with melanoma and nevus
8) Confidence 0.39 Published 2009 Journal Mod. Pathol. Section Title Doc Link 19396153 Disease Relevance 1.24 Pain Relevance 0.19
Ubiquitous melanocytic expression of TRPM1 mRNA was observed in 56 of 95 (59%) Spitz nevi and 4 of 33 (12%) nodular melanomas.
Transcription (expression) of TRPM1 associated with melanoma and nevus
9) Confidence 0.39 Published 2009 Journal Mod. Pathol. Section Abstract Doc Link 19396153 Disease Relevance 1.57 Pain Relevance 0.14
Ubiquitous melanocytic expression of TRPM1 mRNA was observed in 56 of 95 (59%) Spitz nevi and 4 of 33 (12%) nodular melanomas.
Transcription (observed) of TRPM1 associated with melanoma and nevus
10) Confidence 0.39 Published 2009 Journal Mod. Pathol. Section Abstract Doc Link 19396153 Disease Relevance 1.58 Pain Relevance 0.14

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