INT159632

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Context Info
Confidence 0.21
First Reported 2005
Last Reported 2011
Negated 2
Speculated 1
Reported most in Body
Documents 24
Total Number 27
Disease Relevance 18.24
Pain Relevance 6.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DCPS) mitochondrion (DCPS) nucleolus (DCPS)
nucleus (DCPS) cytoplasm (DCPS)
Anatomy Link Frequency
DCs 6
lymphoid tissue 2
blood 1
CD86 1
regulatory T lymphocytes 1
DCPS (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 787 100.00 Very High Very High Very High
Inflammation 236 100.00 Very High Very High Very High
cytokine 228 100.00 Very High Very High Very High
chemokine 58 99.38 Very High Very High Very High
antagonist 6 99.26 Very High Very High Very High
qutenza 1 97.22 Very High Very High Very High
agonist 7 97.02 Very High Very High Very High
Multiple sclerosis 67 95.28 Very High Very High Very High
headache 7 92.92 High High
depression 8 90.72 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 787 100.00 Very High Very High Very High
INFLAMMATION 241 100.00 Very High Very High Very High
Cancer 709 99.80 Very High Very High Very High
Influenza Virus Infection 15 99.16 Very High Very High Very High
Pancreatic Cancer 38 98.76 Very High Very High Very High
Herpes Simplex Virus 4 98.64 Very High Very High Very High
Arthritis 12 97.52 Very High Very High Very High
Stress 7 96.04 Very High Very High Very High
Necrosis 33 95.76 Very High Very High Very High
Demyelinating Disease 70 95.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, the prototypic TRPV1 agonist capsaicin specifically (i.e. via TRPV1) and dose-dependently inhibited cytokine-induced DC differentiation, phagocytosis of bacteria, activation of DCs, and pro-inflammatory cytokine secretion.
Localization (secretion) of DCs in DCs associated with inflammation, qutenza, agonist and cytokine
1) Confidence 0.21 Published 2009 Journal FEBS Lett. Section Abstract Doc Link 19397909 Disease Relevance 0.10 Pain Relevance 0.34
Thus, pDCs are recruited to RA synovial tissue and comprise an APC population distinct from the previously described nuclear RelB+ synovial DCs. pDCs may contribute significantly to the local inflammatory environment.



Localization (recruited) of pDCs in DCs associated with inflammation and rheumatoid arthritis
2) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1065313 Disease Relevance 1.01 Pain Relevance 0.41
DCs are recovered, incubated with antigen, and then aliquoted for individual doses.
Localization (recovered) of DCs
3) Confidence 0.14 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727883 Disease Relevance 0.22 Pain Relevance 0.13
During maturation DCs migrate from tumor tissues to T-cell-rich areas of secondary lymphoid organs, where they activate tumor-reactive CD8+ cytotoxic T lymphocytes (CTLs) and CD4+ T cells.
Localization (migrate) of DCs in cytotoxic T lymphocytes associated with cancer
4) Confidence 0.13 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2975068 Disease Relevance 1.32 Pain Relevance 0.17
This may not give the exact same levels as if analyzed as total numbers of PBMCs per ml blood but gives accurate values of the decrease in DCs occurring in individuals with pancreatic cancer compared to age matched healthy controls.
Localization (decrease) of DCs in blood associated with pancreatic cancer
5) Confidence 0.13 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2847547 Disease Relevance 1.10 Pain Relevance 0.15
Nuclear RelB-CD123+ DCs were located in perivascular regions of RA, in a similar frequency to nuclear RelB+CD123- DCs, but not normal synovial tissue sublining.
Localization (located) of DCs in DCs associated with rheumatoid arthritis
6) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1065313 Disease Relevance 0.95 Pain Relevance 0.41
These nuclear RelB+ DCs are absent in normal synovial tissue and are rare in RA SF [21,23].
Neg (absent) Localization (nuclear) of DCs associated with rheumatoid arthritis
7) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 0.51 Pain Relevance 0.25
CD11c+ myeloid DCs and CD123+ pDCs were compared in normal and RA PB, synovial fluid (SF), and synovial tissue by flow cytometry, immunohistochemistry, and electron microscopy and were sorted for functional studies.
Localization (sorted) of DCs in DCs associated with rheumatoid arthritis
8) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1065313 Disease Relevance 0.92 Pain Relevance 0.40
CD11c+ myeloid DCs and CD123+ pDCs were compared in normal and RA PB, synovial fluid (SF), and synovial tissue by flow cytometry, immunohistochemistry, and electron microscopy and were sorted for functional studies.
Localization (sorted) of pDCs in DCs associated with rheumatoid arthritis
9) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1065313 Disease Relevance 0.92 Pain Relevance 0.40
Nuclear RelB-CD123+ DCs were located in perivascular regions of RA, in a similar frequency to nuclear RelB+CD123- DCs, but not normal synovial tissue sublining.
Localization (located) of DCs in DCs associated with rheumatoid arthritis
10) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1065313 Disease Relevance 0.97 Pain Relevance 0.41
Differentiated nuclear RelB+ DCs are found within the CD11c+ DC population in RA and other inflammatory arthritides but not in normal synovial tissue [21].


Neg (not) Localization (found) of DCs associated with inflammation, rheumatoid arthritis and arthritis
11) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 1.31 Pain Relevance 0.60
Translocation of RelB to the nucleus of myeloid DCs is associated with APC function, particularly through increased expression of MHC molecules CD86 and CD40 [26].
Localization (Translocation) of DCs in CD86
12) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 1.11 Pain Relevance 0.48
To analyse the functional capability of RA SF DCs, CD11c+ and CD123+ DCs were sorted from either normal PB or RA SF and incubated with freshly isolated normal allogeneic PB T cells.
Spec (analyse) Localization (capability) of DCs in T cells associated with rheumatoid arthritis
13) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 0.34 Pain Relevance 0.14
Immature moDCs were harvested and preincubated as above, followed by addition of the diluted zymosan mixture to achieve a ratio of 1 DC:10 particles zymosan (25 ?
Localization (followed) of moDCs
14) Confidence 0.10 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592801 Disease Relevance 0 Pain Relevance 0
Immature DCs (9.6% CCR7+, MFI 23.3) migrated to MIP-1 ?
Localization (Immature) of DCs
15) Confidence 0.09 Published 2008 Journal J Transl Med Section Body Doc Link PMC2265680 Disease Relevance 0.20 Pain Relevance 0.04
Mature DCs were pulsed for 1 h at 37°C with 10 ?
Localization (Mature) of DCs
16) Confidence 0.09 Published 2008 Journal J Transl Med Section Body Doc Link PMC2265680 Disease Relevance 0.08 Pain Relevance 0
Cephalic and extracephalic tDCS reference electrode
Localization (electrode) of tDCS
17) Confidence 0.08 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844382 Disease Relevance 0.60 Pain Relevance 0.30
Furthermore, an antagonist against TLR7/9 inhibited type I IFN secretion from pDCs activated with live influenza or herpes simplex virus as well as immune complexes (R Coffman).
Localization (secretion) of pDCs associated with herpes simplex virus, influenza virus infection and antagonist
18) Confidence 0.08 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 1.45 Pain Relevance 0.43
Production of IL-12 from autologous DCs
Localization (autologous) of DCs
19) Confidence 0.07 Published 2007 Journal J Transl Med Section Body Doc Link PMC2254376 Disease Relevance 0.44 Pain Relevance 0.09
Indeed, IL-4 plays an important role in DC maturation [9] and promotes IL-12 secretion from DCs [10-12].
Localization (secretion) of DCs
20) Confidence 0.07 Published 2007 Journal J Transl Med Section Body Doc Link PMC2254376 Disease Relevance 0.95 Pain Relevance 0.18

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