INT159645

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Context Info
Confidence 0.31
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.84
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Uchl1) intracellular (Uchl1) ligase activity (Uchl1)
response to stress (Uchl1) cytoplasm (Uchl1) cytosol (Uchl1)
Anatomy Link Frequency
brain 2
neurons 1
palate 1
cortex 1
Uchl1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 80 99.40 Very High Very High Very High
Raphe magnus 8 99.32 Very High Very High Very High
cerebral cortex 6 99.32 Very High Very High Very High
Glutamate 41 95.28 Very High Very High Very High
antagonist 18 82.72 Quite High
spinal dorsal horn 1 80.28 Quite High
peripheral neuropathy 3 79.84 Quite High
GABA receptor 3 79.60 Quite High
induced neuropathy 2 75.40 Quite High
Pain 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 77 100.00 Very High Very High Very High
Giant Axonal Neuropathy 7 100.00 Very High Very High Very High
Epilepsy 23 99.76 Very High Very High Very High
Targeted Disruption 19 98.92 Very High Very High Very High
Motor Neuron Diseases 214 98.50 Very High Very High Very High
Cleft Palate 8 98.08 Very High Very High Very High
Convulsion 48 97.24 Very High Very High Very High
Neurodegenerative Disease 20 97.20 Very High Very High Very High
Death 40 96.64 Very High Very High Very High
Neuropathic Pain 4 96.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In line with this we also observed the down-regulation of UCHL1, a neuron-specific ubiquitin carboxy-terminal hydrolase-1, which also displays a secondary dimerization-dependent ubiquitin-ligase activity and represents up to 2% of total soluble brain protein [45].
Negative_regulation (regulation) of UCHL1 in brain
1) Confidence 0.31 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 0.62 Pain Relevance 0.04
The latter phenotype and the observation of poly-ubiquitinated aggregates in ALS create a tantalizing link between the hydrolase activity of UCHL1 and the depletion of UCHL1 mRNA in the motor cortex of SALS patients.
Negative_regulation (depletion) of UCHL1 in cortex associated with motor neuron diseases
2) Confidence 0.31 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 0.69 Pain Relevance 0
In this study, downregulation of the Gan1 gene and the gene protein product, gigaxonin, was validated via quantitative polymerase chain reaction ([qPCR] gene expression) and Western blot analyses (protein level).
Negative_regulation (downregulation) of gene protein product associated with giant axonal neuropathy
3) Confidence 0.18 Published 2009 Journal Biol Res Nurs Section Abstract Doc Link 19398414 Disease Relevance 1.18 Pain Relevance 0.48
This is not inconsistent with the mouse Gad1 knockout where complete loss of Gad1 enzymatic function (~20% reduction of total Gad activity in the cerebral cortex) resulted in a cleft palate phenotype and neonatal death [28,30].
Negative_regulation (reduction) of Gad in palate associated with targeted disruption, cleft palate, generalized anxiety disorder, cerebral cortex and death
4) Confidence 0.14 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544830 Disease Relevance 0.60 Pain Relevance 0.14
In cln3-knockout mice autoantibodies to GAD65 have been reported to be associated with brain tissue and result in inhibition of GAD activity [43].
Negative_regulation (inhibition) of GAD in brain associated with targeted disruption and generalized anxiety disorder
5) Confidence 0.14 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544830 Disease Relevance 1.32 Pain Relevance 0.36
For instance, the presence of autoantibody to GAD was demonstrated in the sera of non-fragile X patients with early onset of chronic drug-resistant epilepsy leading to loss of GAD and decreased GABA synthesis that ultimately contributed to a lower seizure threshold (McKnight et al. 2005).
Negative_regulation (loss) of GAD associated with epilepsy, gaba, convulsion and generalized anxiety disorder
6) Confidence 0.06 Published 2010 Journal Hum Genet Section Body Doc Link PMC2955238 Disease Relevance 1.65 Pain Relevance 0.29
Specifically after PS recovery, five medullary nuclei, the GiA, GiV, RMg, DPGi and LPGi contained a large number of Fos+ neurons, mostly GAD-positive.
Negative_regulation (number) of GAD-positive in neurons associated with raphe magnus and generalized anxiety disorder
7) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629845 Disease Relevance 0.25 Pain Relevance 0.42
Also, approximately one-third of POMC/CART neurones express glutamic acid decarboxylase (GAD) mRNA [47].
Negative_regulation (neurones) of GAD associated with generalized anxiety disorder
8) Confidence 0.04 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.54 Pain Relevance 0.41

General Comments

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