INT159655

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 1.25
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (BDNF) cytoplasmic membrane-bounded vesicle (BDNF)
Anatomy Link Frequency
annulus 4
BDNF (Homo sapiens)
INSRR (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 71 93.44 High High
Neurotransmitter 5 79.44 Quite High
Inflammation 28 76.64 Quite High
Facet joint 4 75.00 Quite High
backache 5 74.12 Quite High
Pain 17 69.12 Quite High
nociceptor 6 66.72 Quite High
cytokine 20 65.80 Quite High
Lasting pain 11 62.48 Quite High
neurotrophin 3 5 52.08 Quite High
Disease Link Frequency Relevance Heat
Nociception 26 78.88 Quite High
INFLAMMATION 28 76.64 Quite High
Low Back Pain 5 74.12 Quite High
Intervertebral Disk Degeneration 10 71.20 Quite High
Pain 38 69.12 Quite High
Disease 6 67.08 Quite High
Hyperalgesia 1 65.44 Quite High
Hypersensitivity 10 47.08 Quite Low
Inflammatory Pain 10 46.40 Quite Low
Cancer 10 39.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The analysis of these specimens revealed the presence of the neurotrophin (NGF) and its own receptor (TrkA) in all cases: the immunohistochemical reaction between the specimens and the specific antibodies marked with FITC was seen under fluoromicroscopy, but in none of the control cases treated with FITC only.
neurotrophin Binding (presence) of own receptor
1) Confidence 0.00 Published 2009 Journal Eur Spine J Section Abstract Doc Link 19399531 Disease Relevance 0.34 Pain Relevance 0.26
These findings provide data on the presence of BDNF and its receptor in the human IVD at the translational level, and on the expression of BDNF and its receptor by cultured human annulus cells.
BDNF Binding (presence) of receptor in annulus
2) Confidence 0.00 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2575628 Disease Relevance 0 Pain Relevance 0
The p75 receptor is of special interest because it also has the ability to bind to BDNF [20].
BDNF Binding (bind) of receptor
3) Confidence 0.00 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575628 Disease Relevance 0.54 Pain Relevance 0.53
The data presented here document the presence of BDNF and its receptor in the human IVD at the translational level, and also show the expression of BDNF and its receptor by cultured human annulus cells.
BDNF Binding (presence) of receptor in annulus
4) Confidence 0.00 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575628 Disease Relevance 0.18 Pain Relevance 0.23
These findings provide data on the presence of BDNF and its receptor in the human IVD at the translational level, and on the expression of BDNF and its receptor by cultured human annulus cells.
BDNF Binding (presence) of receptor in annulus
5) Confidence 0.00 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2575628 Disease Relevance 0 Pain Relevance 0
The data presented here document the presence of BDNF and its receptor in the human IVD at the translational level, and also show the expression of BDNF and its receptor by cultured human annulus cells.
BDNF Binding (presence) of receptor in annulus
6) Confidence 0.00 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575628 Disease Relevance 0.18 Pain Relevance 0.23

General Comments

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