INT159667

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Context Info
Confidence 0.20
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.13
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Bad) cell proliferation (Bad) cytosol (Bad)
mitochondrion (Bad) cytoplasm (Bad)
Anatomy Link Frequency
cardiac myocytes 2
Pituitary 2
Bad (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 7 97.94 Very High Very High Very High
ischemia 24 84.96 Quite High
Inflammation 43 75.48 Quite High
cINOD 10 55.52 Quite High
depression 2 22.08 Low Low
cytokine 20 14.64 Low Low
cva 27 5.00 Very Low Very Low Very Low
agonist 13 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypothermia 138 99.36 Very High Very High Very High
Hemorrhagic Shock 18 97.46 Very High Very High Very High
Apoptosis 71 97.12 Very High Very High Very High
Death 35 91.84 High High
Cv Unclassified Under Development 21 84.96 Quite High
Stress 11 83.48 Quite High
Encephalitis 7 75.48 Quite High
Disease 6 71.72 Quite High
Neurological Disease 1 67.88 Quite High
Shock 2 67.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increase in pro-apoptotic Bad proteins, the decrease in anti-apoptotic Bcl-2 proteins, and caspase activation were all suppressed in the 7018-RGM-1 cells.
Negative_regulation (suppressed) of Positive_regulation (increase) of Bad
1) Confidence 0.20 Published 2009 Journal Digestion Section Body Doc Link 19401612 Disease Relevance 0.21 Pain Relevance 0
Analysis of subcellular localization of Bad shows reduced Bad translocation to mitochondria and a reciprocal accumulation of Bad in cytosolic fractions of cells treated with PPAR?
Negative_regulation (reduced) of Positive_regulation (accumulation) of Bad
2) Confidence 0.10 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 0.69 Pain Relevance 0.14
In rodent model of hemorrhagic shock, profound hypothermia preserved Akt in cardiac myocytes, activated pro-survival proteins including Bcl-2 and beta catenin and suppressed Bad and caspase-3 activation [101].
Negative_regulation (suppressed) of Positive_regulation (activation) of Bad in cardiac myocytes associated with hypothermia and hemorrhagic shock
3) Confidence 0.07 Published 2009 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC2806855 Disease Relevance 1.72 Pain Relevance 0.15
Studies of putative factors for rescue showed that the neuropeptide, Pituitary adenylate cyclase-activating polypeptide (PACAP) increased cell viability, the levels of p-Bad and reduced caspase-3 activation in the NPCs.
Negative_regulation (reduced) of Positive_regulation (activation) of Bad in Pituitary associated with neuropeptide
4) Confidence 0.06 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2885411 Disease Relevance 0.51 Pain Relevance 0.19

General Comments

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