INT159668

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.32
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Bad) cell proliferation (Bad) cytosol (Bad)
mitochondrion (Bad) cytoplasm (Bad)
Anatomy Link Frequency
cardiac myocytes 1
striatum 1
Pituitary 1
heart 1
Bad (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 7 97.94 Very High Very High Very High
Pain 19 96.40 Very High Very High Very High
Inflammatory marker 2 89.04 High High
Anterior cingulate 7 87.52 High High
ischemia 26 84.52 Quite High
insula 3 83.36 Quite High
anesthesia 4 79.76 Quite High
Inflammation 44 75.48 Quite High
cINOD 10 55.52 Quite High
hyperexcitability 1 25.16 Quite Low
Disease Link Frequency Relevance Heat
Hypothermia 138 99.36 Very High Very High Very High
Diabetes Mellitus 10 97.36 Very High Very High Very High
Hemorrhagic Shock 18 97.24 Very High Very High Very High
Apoptosis 126 97.12 Very High Very High Very High
Glaucoma 18 96.28 Very High Very High Very High
Death 47 91.84 High High
Shock 98 90.96 High High
INFLAMMATION 48 89.04 High High
Ocular Hypertension 75 87.68 High High
Parkinson's Disease 3 86.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A significant increase in Bad protein levels and the cleavage of caspase 3 was observed in the diabetic heart.
Positive_regulation (increase) of Bad in heart associated with diabetes mellitus
1) Confidence 0.45 Published 2010 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 20555424 Disease Relevance 1.07 Pain Relevance 0.19
The increase in pro-apoptotic Bad proteins, the decrease in anti-apoptotic Bcl-2 proteins, and caspase activation were all suppressed in the 7018-RGM-1 cells.
Positive_regulation (increase) of Bad
2) Confidence 0.22 Published 2009 Journal Digestion Section Body Doc Link 19401612 Disease Relevance 0.21 Pain Relevance 0
However, taurine treatment inhibited As-induced up-regulation of Bad, Bax and down-regulation of Bcl-2, Bcl-xL.
Positive_regulation (regulation) of Bad
3) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.71 Pain Relevance 0
More important, the attenuation of ubiquitination in axons may result in accumulation of several proapoptotic proteins (e.g., caspases, Bax and Bad) known to be degraded by the proteasome [20] and thus contributes to axonal degeneration in glaucoma.
Positive_regulation (accumulation) of Bad associated with glaucoma
4) Confidence 0.16 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.95 Pain Relevance 0
In rodent model of hemorrhagic shock, profound hypothermia preserved Akt in cardiac myocytes, activated pro-survival proteins including Bcl-2 and beta catenin and suppressed Bad and caspase-3 activation [101].
Positive_regulation (activation) of Bad in cardiac myocytes associated with hypothermia and hemorrhagic shock
5) Confidence 0.12 Published 2009 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC2806855 Disease Relevance 1.72 Pain Relevance 0.15
Analysis of subcellular localization of Bad shows reduced Bad translocation to mitochondria and a reciprocal accumulation of Bad in cytosolic fractions of cells treated with PPAR?
Positive_regulation (accumulation) of Bad
6) Confidence 0.11 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 0.68 Pain Relevance 0.14
Studies of putative factors for rescue showed that the neuropeptide, Pituitary adenylate cyclase-activating polypeptide (PACAP) increased cell viability, the levels of p-Bad and reduced caspase-3 activation in the NPCs.
Positive_regulation (activation) of Bad in Pituitary associated with neuropeptide
7) Confidence 0.07 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2885411 Disease Relevance 0.51 Pain Relevance 0.19
Given that all outcomes were aversive, it is interesting that ventral striatum activity increased for relatively “less bad” outcomes.
Positive_regulation (increased) of bad in striatum
8) Confidence 0.05 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2987510 Disease Relevance 0.47 Pain Relevance 0.22

General Comments

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