INT15969

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Context Info
Confidence 0.43
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 14
Disease Relevance 2.77
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ar) enzyme binding (Ar) DNA binding (Ar)
transcription factor binding (Ar) cytoplasm (Ar)
Anatomy Link Frequency
blood 1
plasma 1
hepatocytes 1
heart 1
preoptic area 1
Ar (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 6 99.52 Very High Very High Very High
palliative 1 99.32 Very High Very High Very High
Enkephalin 9 93.60 High High
medulla 2 87.32 High High
antagonist 5 84.72 Quite High
gABA 1 84.28 Quite High
Central nervous system 1 83.52 Quite High
Endogenous opioid 1 80.04 Quite High
Dorsal horn 1 79.52 Quite High
Spinal cord 1 75.48 Quite High
Disease Link Frequency Relevance Heat
Heart Rate Under Development 90 99.64 Very High Very High Very High
Pressure And Volume Under Development 8 99.64 Very High Very High Very High
Urological Neuroanatomy 2 99.14 Very High Very High Very High
Sprains And Strains 13 98.92 Very High Very High Very High
Prostate Cancer 1 98.36 Very High Very High Very High
Benign Prostatic Hypertrophy 101 96.84 Very High Very High Very High
Hypertension 3 93.76 High High
Breast Cancer 11 91.28 High High
Reprotox - General 1 8 62.32 Quite High
Aberrant Crypt Foci 1 40.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Flutamide, an effective competitive inhibitor of the androgen receptor used orally for palliative treatment of prostatic carcinoma and regulation of prostatic hyperplasia was evaluated for its genotoxic effects in the intact rat and in primary cultures of human hepatocytes.
Negative_regulation (inhibitor) of androgen receptor in hepatocytes associated with benign prostatic hypertrophy, prostate cancer and palliative
1) Confidence 0.43 Published 2000 Journal Pharmacol. Toxicol. Section Abstract Doc Link 10752671 Disease Relevance 0.20 Pain Relevance 0.10
These data suggest, on the one hand, that sexual exhaustion and the postejaculatory interval (which is shortened by bicuculline administration) are not mediated by similar mechanisms and, on the other, that the medial preoptic area does not regulate sexual satiety. (5) The androgen receptor density in brain areas closely related to the expression of masculine sexual behavior, such as the medial preoptic nucleus, was drastically reduced in sexually exhausted animals.
Negative_regulation (reduced) of androgen receptor in preoptic area associated with urological neuroanatomy
2) Confidence 0.43 Published 2003 Journal Scand J Psychol Section Abstract Doc Link 12914589 Disease Relevance 0.19 Pain Relevance 0.22
The present findings suggest that the attenuation of baroreflex bradycardia by castration or androgen receptor blockade involves the interaction between androgens (including testosterone) and the androgen receptor.
Negative_regulation (blockade) of androgen receptor associated with heart rate under development
3) Confidence 0.43 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1403759 Disease Relevance 0.69 Pain Relevance 0.09
Androgen receptor blockade with flutamide significantly decreased BP in both strains (P < 0.0001) and normalized BP in the SHR/y colony.
Negative_regulation (blockade) of Androgen receptor associated with sprains and strains
4) Confidence 0.42 Published 2001 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 11247793 Disease Relevance 0.70 Pain Relevance 0.28
Sodium-induced rise in blood pressure is suppressed by androgen receptor blockade.
Negative_regulation (blockade) of androgen receptor in blood associated with pressure and volume under development
5) Confidence 0.41 Published 2001 Journal Am. J. Physiol. Heart Circ. Physiol. Section Title Doc Link 11247793 Disease Relevance 0.65 Pain Relevance 0.24
Yu and McGinnis [18] reported a decrease in androgen receptor density in the nucleus ambiguus (one of the nuclei implicated in the baroreceptor heart rate response) [19] at 2 weeks castration, a period that coincides with a significant attenuation of baroreflex sensitivity observed in the present study and by others [1,2].
Negative_regulation (decrease) of androgen receptor in heart
6) Confidence 0.39 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC1079884 Disease Relevance 0.20 Pain Relevance 0.04
Transverse sections through L5-6 were obtained from mature male and female rats that were gonadally intact, gonadectomized, or gonadectomized and treated with testosterone, as well as from male rats genetically deficient in androgen receptors (Tfm).
Negative_regulation (deficient) of Tfm
7) Confidence 0.37 Published 1991 Journal J. Neurobiol. Section Abstract Doc Link 1779226 Disease Relevance 0 Pain Relevance 0.55
An overall decrease in COX-2, EGFR, Akt, androgen receptor, and cyclin D1 expression was found associated with tumor growth inhibition.
Negative_regulation (decrease) of androgen receptor
8) Confidence 0.22 Published 2007 Journal Clin. Cancer Res. Section Body Doc Link 17908994 Disease Relevance 0.06 Pain Relevance 0
Effect of E2 on androgen receptor (AR) of prostate with TP (0.74 mg/kg)
Negative_regulation (Effect) of androgen receptor
9) Confidence 0.16 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2959216 Disease Relevance 0 Pain Relevance 0
Effect of E2 on androgen receptor (AR) of prostate with TP (0.15 mg/kg)
Negative_regulation (Effect) of androgen receptor
10) Confidence 0.16 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2959216 Disease Relevance 0 Pain Relevance 0
Effect of E2 on androgen receptor (AR) of prostate with TP (3.7 mg/kg)
Negative_regulation (Effect) of androgen receptor
11) Confidence 0.16 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2959216 Disease Relevance 0 Pain Relevance 0
Effect of E2 on androgen receptor (AR) of prostate with TP (18.5 mg/kg)
Negative_regulation (Effect) of androgen receptor
12) Confidence 0.16 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2959216 Disease Relevance 0 Pain Relevance 0
Further, some studies suggest that tamoxifen may directly bind the androgen receptor and can inhibit androgen receptor activity [58,59].
Negative_regulation (inhibit) of androgen receptor
13) Confidence 0.14 Published 2006 Journal BMC Womens Health Section Body Doc Link PMC1590006 Disease Relevance 0.09 Pain Relevance 0
Gonadectomy reduced plasma testosterone and dihydrotestosterone (DHT) levels compared to intact rats, while subsequent estradiol (E2) or DHT treatment increased plasma E2 and DHT levels, respectively.
Negative_regulation (reduced) of dihydrotestosterone in plasma
14) Confidence 0.08 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8361335 Disease Relevance 0 Pain Relevance 0.08

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