INT1597

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 1979
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 1.38
Pain Relevance 6.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprl1) plasma membrane (Oprl1) signal transducer activity (Oprl1)
Anatomy Link Frequency
brain 2
dorsal root ganglion 2
cortex 2
Oprl1 (Mus musculus)
Pain Link Frequency Relevance Heat
opiate 21 100.00 Very High Very High Very High
agonist 16 100.00 Very High Very High Very High
Kappa opioid receptor 9 100.00 Very High Very High Very High
narcan 8 100.00 Very High Very High Very High
antagonist 5 100.00 Very High Very High Very High
MU agonist 2 100.00 Very High Very High Very High
Dynorphin 6 99.92 Very High Very High Very High
Potency 3 99.70 Very High Very High Very High
dopamine receptor 3 99.36 Very High Very High Very High
withdrawal 6 98.86 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 1 99.10 Very High Very High Very High
Ganglion Cysts 1 97.92 Very High Very High Very High
Neuroblastoma 2 97.46 Very High Very High Very High
Glioma 1 94.96 High High
Congenital Anomalies 1 93.44 High High
Microcephaly 1 92.16 High High
Opiate Addiction 2 91.00 High High
Death 1 83.36 Quite High
Apoptosis 7 82.80 Quite High
Neurological Disease 1 81.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ethanol acutely inhibited opiate receptor binding, but after chronic exposure the cells exhibited an apparent adaptive increase in the number of opiate binding sites; this was reversible when ethanol was withdrawn.
Negative_regulation (inhibited) of opiate receptor Binding (binding) of associated with opiate
1) Confidence 0.59 Published 1984 Journal Ciba Found. Symp. Section Abstract Doc Link 6563992 Disease Relevance 0.42 Pain Relevance 0.58
Furthermore, the potency of U50,488 to inhibit the binding of the opiate antagonist [3H]naloxone to the kappa receptor is reduced.
Negative_regulation (inhibit) of kappa receptor Binding (binding) of associated with antagonist, narcan, opiate and potency
2) Confidence 0.57 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932192 Disease Relevance 0 Pain Relevance 0.96
Each of them, however, was less potent than the comparable 3-hydroxy analogue, and their binding affinity to the opiate receptor was substantially decreased.
Negative_regulation (decreased) of opiate receptor Binding (affinity) of associated with opiate
3) Confidence 0.54 Published 1979 Journal J. Med. Chem. Section Abstract Doc Link 218012 Disease Relevance 0 Pain Relevance 0.59
These nociceptin-stimulated activities were not affected by naloxone, naltrindol nor norbinaltorphimine which completely blocked mu-, delta- or kappa-opioid agonist-stimulated GTPgammaS binding, respectively.
Negative_regulation (blocked) of kappa-opioid Binding (binding) of associated with mu agonist, orphanin and narcan
4) Confidence 0.51 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9453228 Disease Relevance 0 Pain Relevance 0.63
In mouse brain cortex membranes, the binding of the ORL1 receptor agonist [3H]nociceptin was equipotently inhibited by Mr 2266 and its enantiomer Mr 2267 (pK(i) 4.82 and 5.14, respectively), whereas the binding of the kappa-opioid receptor agonist [3H]U-69,593 was inhibited by Mr 2266 more potently (pK(i) 9.11) than by its enantiomer Mr 2267 (pK(i)7.15).
Negative_regulation (inhibited) of kappa-opioid receptor Binding (binding) of in cortex associated with orphanin, kappa opioid receptor, agonist and opioid
5) Confidence 0.43 Published 1999 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9933145 Disease Relevance 0 Pain Relevance 0.98
An immortalized mouse neuroblastoma x dorsal root ganglion hybrid cell line stably transfected to overexpress kappa-opioid receptors (F-11kappa7) showed complete loss of kappa-receptor binding to [3H]U69,593 after exposure to the kappa-agonist U69,593 for 24 h.
Negative_regulation (loss) of kappa-receptor Binding (binding) of in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, neuroblastoma, agonist and kappa opioid receptor
6) Confidence 0.34 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9166729 Disease Relevance 0.69 Pain Relevance 0.31
Predisposition to nitrous oxide withdrawal convulsions as judged by duration of susceptibility was decreased significantly after pretreatment with the cholinesterase inhibitors, physostigmine and galanthamine, or with the opiate receptor blocking agent naloxone.
Negative_regulation (decreased) of opiate receptor Binding (pretreatment) of associated with convulsion, narcan, opiate and withdrawal
7) Confidence 0.33 Published 1983 Journal Anesthesiology Section Abstract Doc Link 6683088 Disease Relevance 0.27 Pain Relevance 0.37
The probable mechanism of dynorphin in decreasing opiate receptor binding is discussed.
Negative_regulation (decreasing) of opiate receptor Binding (binding) of associated with dynorphin and opiate
8) Confidence 0.30 Published 1983 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6311575 Disease Relevance 0 Pain Relevance 0.58
Since ethanol, in vitro, does decrease striatal opiate receptor binding, the results suggest that the changes in affinity detected by ligand binding studies are not relevant for receptor-coupled adenylate cyclase activity, or that opiate receptor binding and opiate regulation of adenylate cyclase can be modulated independently.
Negative_regulation (decrease) of opiate receptor Binding (binding) of associated with opiate
9) Confidence 0.18 Published 1986 Journal J. Neurochem. Section Abstract Doc Link 3512771 Disease Relevance 0 Pain Relevance 0.77
At 16 days, postnatally (P16), a period that marks the end of the postnatal spurt in brain growth, dopamine receptor binding was still elevated and opiate receptor binding was still diminished.
Negative_regulation (diminished) of opiate receptor Binding (binding) of in brain associated with dopamine receptor and opiate
10) Confidence 0.04 Published 1984 Journal Brain Res. Section Abstract Doc Link 6098328 Disease Relevance 0 Pain Relevance 0.57
They also inhibited binding to the opiate receptor.
Negative_regulation (inhibited) of opiate receptor Binding (binding) of associated with opiate
11) Confidence 0.01 Published 1988 Journal J. Recept. Res. Section Abstract Doc Link 2838616 Disease Relevance 0 Pain Relevance 0.29

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox