INT159707

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Context Info
Confidence 0.66
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.69
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ERAP1) peptidase activity (ERAP1) extracellular region (ERAP1)
endoplasmic reticulum (ERAP1)
Anatomy Link Frequency
covering 1
46-2 1
ERAP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 11 50.00 Quite Low
Inflammatory response 1 35.28 Quite Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 6 99.96 Very High Very High Very High
Low Back Pain 11 87.32 High High
Disease Susceptibility 2 75.84 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 56.88 Quite High
INFLAMMATION 4 35.28 Quite Low
Eclampsia 6 5.00 Very Low Very Low Very Low
Malaria 4 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low
Reprotox - General 1 1 5.00 Very Low Very Low Very Low
Hypertension 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Family-based association testing (FBAT -e; empirical variance option) analysis showed that ERAP1 rs30187[T] was associated with AS (additive model: p=0.02; dominant model: p=0.007).
Gene_expression (rs30187[T) of ERAP1
1) Confidence 0.66 Published 2010 Journal Ann. Rheum. Dis. Section Body Doc Link 19433412 Disease Relevance 0.08 Pain Relevance 0
This result is consistent with the reduced MHC class I cell-surface expression observed after transient knock-down of ERAP1 or ERAP2 in cultured cells [48], the reduced MHC class I cell-surface expression seen in ERAP1-knock-out mice [54]–[56], [61], and our observation that ERAP1 is not upregulated to compensate for ERAP2 deficiency in cells from BB-homozygotes (Text S1).
Gene_expression (expression) of ERAP1 associated with targeted disruption
2) Confidence 0.62 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.38 Pain Relevance 0
RESULTS: A specific ERAP1 haplotype, rs27044/10050860/30187-CCT, was strongly associated with increased risk of AS in all 3 case-control cohorts (pooled odds ratio [OR] 1.81, 95% confidence interval [95% CI] 1.46-2.24; P=7x10(-8)), while a second specific ERAP1 haplotype, rs30187/26618/26653-CTG, reduced the disease risk (pooled OR 0.77, 95% CI 0.67-0.88; P=9x10(-5)).
Gene_expression (haplotype) of ERAP1 in 46-2
3) Confidence 0.61 Published 2009 Journal Arthritis Rheum. Section Body Doc Link 19404951 Disease Relevance 0.15 Pain Relevance 0
The Sequenom iPlex platform was used to genotype cases and controls for 21 tag SNPs covering IL23R and 38 tag SNPs covering ERAP1.
Gene_expression (covering) of ERAP1 in covering
4) Confidence 0.35 Published 2009 Journal Arthritis Rheum. Section Body Doc Link 19877036 Disease Relevance 0.09 Pain Relevance 0

General Comments

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