INT159709

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Context Info
Confidence 0.47
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 3.42
Pain Relevance 2.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ERAP1) peptidase activity (ERAP1) extracellular region (ERAP1)
endoplasmic reticulum (ERAP1)
ERAP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 86 100.00 Very High Very High Very High
Inflammation 9 90.12 High High
spondylitis 6 72.64 Quite High
rheumatoid arthritis 4 45.92 Quite Low
Crohn's disease 15 41.68 Quite Low
psoriasis 4 29.52 Quite Low
Arthritis 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Low Back Pain 50 100.00 Very High Very High Very High
Disease Susceptibility 7 99.36 Very High Very High Very High
Ankylosing Spondylitis 42 96.52 Very High Very High Very High
Disease 36 96.16 Very High Very High Very High
Rheumatic Diseases 1 90.88 High High
INFLAMMATION 4 90.12 High High
Rheumatoid Arthritis 4 45.92 Quite Low
Diabetes Mellitus 5 43.20 Quite Low
Inflammatory Bowel Disease 25 32.48 Quite Low
Psoriasis 4 29.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Association of an ERAP1 ERAP2 haplotype with familial ankylosing spondylitis.
ERAP1 Binding (Association) of associated with spinal inflammation
1) Confidence 0.47 Published 2010 Journal Ann. Rheum. Dis. Section Title Doc Link 19433412 Disease Relevance 0.10 Pain Relevance 0.19
Association of a specific ERAP1/ARTS1 haplotype with disease susceptibility in ankylosing spondylitis.
ARTS1 Binding (Association) of associated with disease susceptibility and spinal inflammation
2) Confidence 0.47 Published 2009 Journal Arthritis Rheum. Section Title Doc Link 19404951 Disease Relevance 0.38 Pain Relevance 0.36
Association of a specific ERAP1/ARTS1 haplotype with disease susceptibility in ankylosing spondylitis.
ERAP1 Binding (Association) of associated with disease susceptibility and spinal inflammation
3) Confidence 0.43 Published 2009 Journal Arthritis Rheum. Section Title Doc Link 19404951 Disease Relevance 0.38 Pain Relevance 0.36
Significant associations were also noted for 3 ERAP1 SNP variants (rs10050860, rs30187, and rs26653), although no significant haplotype interaction between ERAP1 and TAP/LMP loci was evident.
ERAP1 Neg (no) Binding (interaction) of
4) Confidence 0.32 Published 2009 Journal Arthritis Rheum. Section Body Doc Link 19404951 Disease Relevance 0.11 Pain Relevance 0
Apart from the well known HLA-B27 association, recent genetic studies have identified ERAP1, IL23R and 2 intergenic regions at chr2p15 and chr21q22 as genes/loci associated with AS [3], [4].
ERAP1 Binding (association) of associated with spinal inflammation
5) Confidence 0.32 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2996314 Disease Relevance 0.91 Pain Relevance 0.49
Association of IL23R and ERAP1 genes with ankylosing spondylitis in a Portuguese population.
ERAP1 Binding (Association) of associated with spinal inflammation
6) Confidence 0.29 Published 2009 Journal Clin. Exp. Rheumatol. Section Title Doc Link 19917163 Disease Relevance 0.59 Pain Relevance 0.52
CONCLUSION: These results show that IL23R and ERAP1 genes are also associated with susceptibility to AS in the Portuguese population, and that they contribute a significant proportion of the population risk for this disease.


ERAP1 Binding (associated) of
7) Confidence 0.28 Published 2009 Journal Clin. Exp. Rheumatol. Section Body Doc Link 19917163 Disease Relevance 0 Pain Relevance 0
OBJECTIVE: To test the association between ARTS1 polymorphisms and Koreans with ankylosing spondylitis (AS).
ARTS1 Binding (association) of associated with spinal inflammation
8) Confidence 0.26 Published 2010 Journal Ann. Rheum. Dis. Section Abstract Doc Link 19414429 Disease Relevance 0.17 Pain Relevance 0.17
OBJECTIVE: The results of a recent genome-wide association study have shown that ERAP1 and IL23R are associated with ankylosing spondylitis (AS) in Caucasian populations from North America and the UK.
ERAP1 Binding (associated) of associated with spinal inflammation
9) Confidence 0.25 Published 2009 Journal Arthritis Rheum. Section Abstract Doc Link 19877036 Disease Relevance 0.27 Pain Relevance 0.35
Haplotype analysis revealed association of 2 ARTS1 haplotypes with AS in the Hungarian population.
ARTS1 Binding (association) of
10) Confidence 0.22 Published 2010 Journal J. Rheumatol. Section Body Doc Link 20032103 Disease Relevance 0.07 Pain Relevance 0
CONCLUSION: We confirmed reported associations of ARTS1 gene polymorphisms with AS in a Hungarian cohort study.
ARTS1 Binding (associations) of
11) Confidence 0.20 Published 2010 Journal J. Rheumatol. Section Body Doc Link 20032103 Disease Relevance 0.05 Pain Relevance 0
Association of ARTS1 gene polymorphisms with ankylosing spondylitis in the Hungarian population: the rs27044 variant is associated with HLA-B*2705 subtype in Hungarian patients with ankylosing spondylitis.
ARTS1 Binding (Association) of associated with spinal inflammation
12) Confidence 0.20 Published 2010 Journal J. Rheumatol. Section Title Doc Link 20032103 Disease Relevance 0.37 Pain Relevance 0.46

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