INT159750

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Context Info
Confidence 0.40
First Reported 2006
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 15
Total Number 17
Disease Relevance 10.88
Pain Relevance 7.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mapk14) cell morphogenesis (Mapk14) response to stress (Mapk14)
cytoplasm (Mapk14) cytosol (Mapk14) nucleus (Mapk14)
Anatomy Link Frequency
trigeminal ganglia 4
neuronal 2
spinal 2
sciatic nerve 2
spinal cord 2
Mapk14 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 144 100.00 Very High Very High Very High
antagonist 60 99.84 Very High Very High Very High
Cancer pain 5 99.80 Very High Very High Very High
Morphine 38 99.70 Very High Very High Very High
narcan 7 99.42 Very High Very High Very High
Sciatic nerve 13 99.40 Very High Very High Very High
Spontaneous pain 5 99.32 Very High Very High Very High
intrathecal 73 99.30 Very High Very High Very High
ischemia 193 99.16 Very High Very High Very High
Brush evoked pain 5 98.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypersensitivity 67 100.00 Very High Very High Very High
Cancer Pain 5 99.80 Very High Very High Very High
Pain 123 99.32 Very High Very High Very High
Nervous System Injury 103 99.24 Very High Very High Very High
Pulmonary Disease 107 99.20 Very High Very High Very High
Cv Unclassified Under Development 139 99.16 Very High Very High Very High
Neuropathic Pain 109 98.90 Very High Very High Very High
Nociception 86 96.68 Very High Very High Very High
Retina Disease 58 96.00 Very High Very High Very High
Hyperalgesia 60 95.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evaluation of articular gene expression by quantitative real-time PCR showed that spinal p38 inhibition markedly decreased synovial interleukin-1 and ?
Negative_regulation (decreased) of Neg (inhibition) Gene_expression (inhibition) of p38 in spinal
1) Confidence 0.40 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1560929 Disease Relevance 1.17 Pain Relevance 0.92
On the other hand, a 3-day administration [4 microg/rat/day, intrathecally (i.t.)] of 4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole (SB203580), an inhibitor of p38MAPK, could suppress tactile allodynia and spontaneous pain of the bone cancer pain rats and decrease the phosphorylation of p38 as well as the expression of IL-1beta and TNF-alpha.
Negative_regulation (decrease) of Gene_expression (expression) of p38 associated with pain, brush evoked pain, cancer pain and spontaneous pain
2) Confidence 0.35 Published 2010 Journal Brain Res. Section Abstract Doc Link 20478276 Disease Relevance 1.29 Pain Relevance 1.08
P38 kinase (Upstate Biotechnology, Charlottesville, VA) was assayed in triplicate in a kinase buffer containing 25 mM HEPES, 25 mM ?
Negative_regulation (assayed) of Gene_expression (kinase) of P38
3) Confidence 0.34 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2612656 Disease Relevance 0.58 Pain Relevance 0.26
Lidocaine, by inhibiting the increase of intracellular calcium, also inhibited p38 MAPK activation and attenuated the production of proinflammatory cytokines (including TNF-alpha, IL-1beta, and IL-6), which were triggered by extracellular ATP in cultured rat microglia.


Negative_regulation (inhibited) of Gene_expression (activation) of p38 in microglia
4) Confidence 0.33 Published 2010 Journal Anesth. Analg. Section Body Doc Link 20686009 Disease Relevance 0 Pain Relevance 0
Anti-IL-10 antibody and SB203580 significantly inhibited the amitriptyline-induced p38 mitogen-activated protein kinase and heme oxygenase-1 expression and the associated antiinflammatory effect of amitriptyline.
Negative_regulation (inhibited) of Gene_expression (expression) of p38
5) Confidence 0.33 Published 2009 Journal Anesthesiology Section Body Doc Link 19417613 Disease Relevance 0 Pain Relevance 0
Ultra-low dose naloxone plus morphine significantly inhibited the effect of PTX on P-p38 MAPK expression in the spinal cord, while the p38 MAPK inhibitor SB203580 attenuated the PTX-induced mechanical allodynia, thermal hyperalgesia, increase in spinal cerebrospinal fluid excitatory amino acids, and downregulation of GTs.
Negative_regulation (inhibited) of Gene_expression (expression) of p38 in spinal cord associated with allodynia, thermal hyperalgesia, narcan, excitatory amino acid, spinal cord and morphine
6) Confidence 0.30 Published 2009 Journal Neuroscience Section Abstract Doc Link 19409222 Disease Relevance 0.46 Pain Relevance 1.25
Third, SNI-induced microglial proliferation and p38 activation in the spinal cord was reduced by a complete sciatic nerve blockade with bupivacaine microspheres but not by a selective blockade of nociceptive fibers with RTX.
Neg (not) Negative_regulation (reduced) of Gene_expression (activation) of p38 in sciatic nerve associated with nociception, nervous system injury, sciatic nerve and spinal cord
7) Confidence 0.29 Published 2009 Journal Mol Pain Section Body Doc Link PMC2759920 Disease Relevance 1.48 Pain Relevance 0.63
These data showed that BV injection significantly induced p38 activation from 1 hr to 3 d, at which point p38 activation began to decrease.
Negative_regulation (decrease) of Gene_expression (activation) of p38
8) Confidence 0.28 Published 2008 Journal Mol Pain Section Body Doc Link PMC2391153 Disease Relevance 0.05 Pain Relevance 0.24
There was an early increase in ERK1/2 and c-jun levels in the neuroretina, while JNK was slightly decreased. p38 expression was not affected by ischemia.
Negative_regulation (decreased) of Gene_expression (expression) of p38 in neuroretina associated with ischemia
9) Confidence 0.24 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838742 Disease Relevance 1.07 Pain Relevance 0.34
Lee et al. [42] reported constitutive expression of activated p38?
Negative_regulation (reported) of Gene_expression (expression) of p38
10) Confidence 0.24 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838742 Disease Relevance 0.90 Pain Relevance 0.33
We provide evidence for the functional significance of these astrocytic changes by demonstrating that intrathecal administration of propentofylline (50 µg, i.t.) attenuated both persistent behavioral hypersensitivity and over-expression of GFAP and phospho-p38 in antagonist-treated animals.


Negative_regulation (attenuated) of Gene_expression (expression) of p38 associated with antagonist, hypersensitivity and intrathecal
11) Confidence 0.18 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2878341 Disease Relevance 0.69 Pain Relevance 0.82
We also provide evidence for the functional significance of these astrocytic changes by demonstrating that intrathecal administration of propentofylline attenuated both persistent hypersensitivity and over-expression of GFAP and phospho-p38 in animals treated with AM281 + AM630.
Negative_regulation (attenuated) of Gene_expression (expression) of p38 associated with hypersensitivity and intrathecal
12) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2878341 Disease Relevance 0.74 Pain Relevance 0.55
Importantly, a marked decrease in neuronal P-p38 expression to basal levels was seen in animals pretreated with GSE prior to injection of CFA.
Negative_regulation (decrease) of Gene_expression (expression) of p38 in neuronal
13) Confidence 0.09 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0 Pain Relevance 0
We propose that the basal increase in MKP-1 mediated by dietary GSE is responsible, at least in part, for the repressed expression of P-p38 in trigeminal ganglia and TNC neurons and glia in response to CFA since MKP-1 is a primary regulator of p38 activity [33].
Negative_regulation (repressed) of Gene_expression (expression) of p38 in trigeminal ganglia
14) Confidence 0.07 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0.64 Pain Relevance 0.50
Importantly, we found that the stimulatory effects of CFA on P-p38 expression in trigeminal ganglia and TNC were significantly repressed in animals receiving GSE.
Negative_regulation (repressed) of Gene_expression (expression) of p38 in trigeminal ganglia
15) Confidence 0.07 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0.58 Pain Relevance 0.53
Another p38 inhibitor, SD-282, reduced LPS-induced production of TNF-?
Negative_regulation (inhibitor) of Gene_expression (production) of p38
16) Confidence 0.04 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 0.58 Pain Relevance 0.16
B and activator protein 1 and the reduction of the expression of p38 mitogen-activated protein kinase by pentobarbital [125].
Negative_regulation (reduction) of Gene_expression (expression) of p38
17) Confidence 0.02 Published 2010 Journal Crit Care Section Body Doc Link PMC2887136 Disease Relevance 0.64 Pain Relevance 0.20

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