INT159769

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Context Info
Confidence 0.64
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 2.66
Pain Relevance 2.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Hcn1)
Anatomy Link Frequency
neurons 6
Hcn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
hCN2 13 100.00 Very High Very High Very High
HCN1 11 100.00 Very High Very High Very High
Inflammation 7 98.00 Very High Very High Very High
c fibre 12 97.92 Very High Very High Very High
opioid receptor 2 94.16 High High
agonist 2 92.24 High High
Buprenorphine 2 91.52 High High
Trigeminal ganglion neurons 2 75.48 Quite High
hyperexcitability 1 68.32 Quite High
Pain 1 64.16 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 14 99.98 Very High Very High Very High
Ganglion Cysts 12 99.62 Very High Very High Very High
INFLAMMATION 5 98.00 Very High Very High Very High
Diabetic Neuropathy 2 75.36 Quite High
Pain 1 64.16 Quite High
Nervous System Injury 1 63.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compared to the sham NG neurons, diabetes induced the expression of HCN2 in the A-fiber neurons besides overexpression of HCN1 and HCN3; and enhanced the expression of HCN2 and HCN3 in C-fiber neurons.
Positive_regulation (induced) of Gene_expression (overexpression) of HCN1 in neurons associated with ganglion cysts, c fibre, diabetes mellitus, hcn1 and hcn2
1) Confidence 0.64 Published 2010 Journal Neuroscience Section Abstract Doc Link 19815055 Disease Relevance 1.03 Pain Relevance 0.75
In addition, the number of retrogradely labeled neurons from the dura expressing HCN1 and HCN2 was significantly increased to 247% (HCN1) and 171% (HCN2), three days after inflammation.
Positive_regulation (increased) of Gene_expression (expressing) of HCN1 in neurons associated with inflammation, hcn1 and hcn2
2) Confidence 0.49 Published 2009 Journal Neuroscience Section Abstract Doc Link 19409968 Disease Relevance 0.61 Pain Relevance 1.33
Compared to the sham NG neurons, diabetes induced the expression of HCN2 in the A-fiber neurons besides overexpression of HCN1 and HCN3; and enhanced the expression of HCN2 and HCN3 in C-fiber neurons.
Positive_regulation (overexpression) of Gene_expression (overexpression) of HCN1 in neurons associated with ganglion cysts, c fibre, diabetes mellitus, hcn1 and hcn2
3) Confidence 0.43 Published 2010 Journal Neuroscience Section Abstract Doc Link 19815055 Disease Relevance 1.02 Pain Relevance 0.75

General Comments

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