INT159771

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Context Info
Confidence 0.49
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 2.66
Pain Relevance 2.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Cnga1) cytoplasm (Cnga1)
Anatomy Link Frequency
afferent neurons 4
Cnga1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 7 99.82 Very High Very High Very High
Buprenorphine 2 98.52 Very High Very High Very High
agonist 2 98.22 Very High Very High Very High
c fibre 12 98.12 Very High Very High Very High
opioid receptor 2 97.90 Very High Very High Very High
hCN2 13 93.48 High High
HCN1 11 92.84 High High
hyperexcitability 1 86.48 High High
Trigeminal ganglion neurons 2 75.00 Quite High
Pain 1 54.36 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 14 99.98 Very High Very High Very High
INFLAMMATION 5 99.82 Very High Very High Very High
Ganglion Cysts 12 81.48 Quite High
Diabetic Neuropathy 2 57.60 Quite High
Pain 1 54.36 Quite High
Nervous System Injury 1 53.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When the opioid receptor partial agonist, buprenorphine, was given systemically, immediately after CFA, the inflammation-induced increase in HCN protein expression in both Western blot and immunohistochemical experiments was not observed.
Positive_regulation (increase) of Gene_expression (expression) of HCN protein associated with inflammation, agonist, opioid receptor and buprenorphine
1) Confidence 0.49 Published 2009 Journal Neuroscience Section Abstract Doc Link 19409968 Disease Relevance 0.58 Pain Relevance 1.32
These results indicate that diabetes induces the overexpression of HCN channels and the electrophysiological changes of HCN currents in the A- and C-fiber nodose neurons, which might contribute to the diabetes-induced alteration of cell excitability in the vagal afferent neurons.
Positive_regulation (induces) of Gene_expression (overexpression) of HCN in afferent neurons associated with c fibre and diabetes mellitus
2) Confidence 0.27 Published 2010 Journal Neuroscience Section Abstract Doc Link 19815055 Disease Relevance 1.04 Pain Relevance 0.73
These results indicate that diabetes induces the overexpression of HCN channels and the electrophysiological changes of HCN currents in the A- and C-fiber nodose neurons, which might contribute to the diabetes-induced alteration of cell excitability in the vagal afferent neurons.
Positive_regulation (overexpression) of Gene_expression (overexpression) of HCN in afferent neurons associated with c fibre and diabetes mellitus
3) Confidence 0.18 Published 2010 Journal Neuroscience Section Abstract Doc Link 19815055 Disease Relevance 1.04 Pain Relevance 0.73

General Comments

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