INT159772

Context Info Confidence 0.26 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.53 Pain Relevance 0.71

aging (Hcn2) plasma membrane (Hcn2) transmembrane transport (Hcn2)

Anatomy Link Frequency neurons 1 Hcn2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat hCN2 7 100.00 HCN1 7 99.90 Inflammation 7 99.08 Trigeminal ganglion neurons 2 97.72 Pain 1 93.20 Neuronal excitability 1 89.36 Buprenorphine 2 75.00 opioid receptor 2 34.24 agonist 2 32.32 hyperexcitability 1 25.00

Disease Link Frequency Relevance Heat INFLAMMATION 5 99.08 Ganglion Cysts 2 97.28 Pain 1 93.20 Nervous System Injury 1 92.68

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

HCN1 and HCN2 channel immunoreactivity was observed on the membranes of medium- to large-sized trigeminal ganglion neurons with 76% and 85% of HCN1 and HCN2 expressing neurons also containing the 200 kDa neurofilament protein (associated with myelinated fibers).

Regulation (immunoreactivity) of HCN2 in neurons associated with ganglion cysts, hcn1, trigeminal ganglion neurons and hcn2

1) Confidence 0.26 Published 2009 Journal Neuroscience Section Abstract Doc Link 19409968 Disease Relevance 0.53 Pain Relevance 0.71

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