INT159777

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.54
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Shbg) extracellular region (Shbg)
Anatomy Link Frequency
heart 2
central nervous system 2
urogenital system 2
Shbg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 8 100.00 Very High Very High Very High
Dismenorea 4 98.76 Very High Very High Very High
headache 5 86.28 High High
withdrawal 2 83.92 Quite High
depression 5 5.00 Very Low Very Low Very Low
sSRI 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
transdermal 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis (extended) 16 100.00 Very High Very High Very High
Reprotox - General 3 13 99.20 Very High Very High Very High
Heart Rate Under Development 3 98.96 Very High Very High Very High
Reprotox - General 1 3 98.76 Very High Very High Very High
Reprotox - General 2 3 87.12 High High
Incontinence 1 86.40 High High
Headache 6 86.28 High High
Sleep Disorders 3 85.88 High High
Substance Withdrawal Syndrome 2 84.28 Quite High
Frailty 1 83.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The decline in sex hormone levels that accompanies the menopause has substantial effects on the tissues of the urogenital system, leading to atrophic changes.
Regulation (effects) of Negative_regulation (decline) of sex hormone in urogenital system associated with endometriosis (extended)
1) Confidence 0.41 Published 2009 Journal Maturitas Section Abstract Doc Link 19410391 Disease Relevance 0.48 Pain Relevance 0.09
These effects may depend on both estrogenic and androgenic actions exerted at the genital level and in the central nervous system, and on a reduction of sex-hormone-binding globulin and an increase of free testosterone, without affecting ?
Spec (may) Regulation (depend) of Negative_regulation (reduction) of sex-hormone-binding globulin in central nervous system associated with central nervous system
2) Confidence 0.29 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Abstract Doc Link PMC2671819 Disease Relevance 0.91 Pain Relevance 0.28
Similar findings, i.e., reduction in SBP, DBP, and heart rate were observed in two other studies.[2324]
Regulation (observed) of Negative_regulation (reduction) of SBP in heart
3) Confidence 0.10 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2991702 Disease Relevance 0.15 Pain Relevance 0

General Comments

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