INT159784

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Context Info
Confidence 0.61
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 6.28
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk9) mitochondrion (Mapk9) nucleus (Mapk9)
kinase activity (Mapk9) transcription factor binding (Mapk9) cytoplasm (Mapk9)
Anatomy Link Frequency
testis 1
MDBK 1
brain 1
heart 1
frontal cortex 1
Mapk9 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 9 100.00 Very High Very High Very High
Hippocampus 3 99.68 Very High Very High Very High
Spinal cord 7 98.88 Very High Very High Very High
fluoxetine 2 94.04 High High
depression 8 88.08 High High
Inflammation 107 87.72 High High
Dorsal horn 4 86.08 High High
pain pelvic 1 83.04 Quite High
endometriosis 2 82.28 Quite High
tolerance 7 79.92 Quite High
Disease Link Frequency Relevance Heat
Adhesions 1 100.00 Very High Very High Very High
Stress 21 99.70 Very High Very High Very High
Urological Neuroanatomy 3 98.52 Very High Very High Very High
Infection 25 96.12 Very High Very High Very High
Disorder Of Lipid Metabolism 51 94.52 High High
Insulin Resistance 25 92.96 High High
Hepatocellular Cancer 189 90.20 High High
Obesity 34 89.20 High High
Endometriosis 4 88.68 High High
Depression 8 88.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, a recent analysis revealed that the 46- and 54-kDa molecules represent two isoforms of JNK1 and JNK2, whereas the 46-kDa JNK1 and 54-kDa JNK2 are dominantly expressed in most cell and tissue types [42].
Gene_expression (expressed) of JNK2
1) Confidence 0.61 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.66 Pain Relevance 0.06
The JNK subgroup of MAPKs is encoded by three loci; Jnk1 and Jnk2 are ubiquitously expressed, and Jnk3 is expressed primarily in heart, testis, and brain [38–40].
Gene_expression (expressed) of Jnk2 in brain
2) Confidence 0.48 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.63 Pain Relevance 0.04
As shown in Figure 3C, no change was detected in the myocardial levels of FAK (Focal Adhesion Kinase), JNK (c-Jun N-Terminal Kinase) or Shp2 (Src homology region 2, phosphatase 2) after treatment with siMEF2C.
Gene_expression (levels) of c-Jun N-Terminal Kinase associated with adhesions
3) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.15 Pain Relevance 0
RT2 profiler PCR array analysis showed that berberine
                 upregulated the expression of glucose transporter 4 (GLUT4), mitogen-activated protein kinase 14 (MAPK14), 
                 MAPK8(c-jun N-terminal kinase, JNK), peroxisome proliferator-activated receptor ? 
Gene_expression (expression) of c-jun N-terminal kinase
4) Confidence 0.28 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Abstract Doc Link PMC2952334 Disease Relevance 0.40 Pain Relevance 0.04
Individually and in various combinations these compounds also demonstrated favorable modulation of the activity of proteins and kinases implicated in insulin signaling such as PI3K, GSK-3, AKT, PKC and c-Jun N-terminal kinase (manuscript in preparation).
Gene_expression (signaling) of c-Jun N-terminal kinase associated with kinase c
5) Confidence 0.20 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2588603 Disease Relevance 0.97 Pain Relevance 0.13
The JNK subgroup of MAPKs is encoded by three loci; Jnk1 and Jnk2 are ubiquitously expressed, and Jnk3 is expressed primarily in heart, testis, and brain [38–40].
Gene_expression (expressed) of Jnk2 in testis
6) Confidence 0.16 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.63 Pain Relevance 0.04
The JNK subgroup of MAPKs is encoded by three loci; Jnk1 and Jnk2 are ubiquitously expressed, and Jnk3 is expressed primarily in heart, testis, and brain [38–40].
Gene_expression (expressed) of Jnk2 in heart
7) Confidence 0.16 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.63 Pain Relevance 0.04
Moreover, in CNS, hypertonicity induces AQP-1 synthesis via extracellular signal-regulated kinases, p38 kinase, and c-Jun terminal kinase [44].
Gene_expression (synthesis) of c-Jun terminal kinase
8) Confidence 0.12 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 0.62 Pain Relevance 0.35
Using the NF-kappaB pathway array, we found that TNFalpha upregulated ICAM-3, IL-6, IL-8, TAK1, JNK2, RelA, and TLR4 expressions.
Gene_expression (expressions) of JNK2
9) Confidence 0.05 Published 2009 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 19410630 Disease Relevance 0.41 Pain Relevance 0.19
Interestingly, we routinely detected JNK1 and JNK2 expression and phosphorylation in Vero cells, whereas expression of only one JNK isoform and phosphorylation could be detected in MDBK cells.
Gene_expression (expression) of JNK2 in MDBK
10) Confidence 0.04 Published 2009 Journal Veterinary Research Section Body Doc Link PMC2785050 Disease Relevance 0.16 Pain Relevance 0
Western blot study revealed that rats subjected to prenatal stress had decreased levels of p-JNK1 and p-JNK2 in the hippocampus and p-p38 in the frontal cortex, but the concentrations of p-ERK1 and p-ERK2 were not changed.
Gene_expression (levels) of p-JNK2 in frontal cortex associated with stress, urological neuroanatomy and hippocampus
11) Confidence 0.01 Published 2010 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 20436222 Disease Relevance 1.02 Pain Relevance 0.47

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