INT15980

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Context Info
Confidence 0.50
First Reported 1991
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 2.99
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Agt) aging (Agt) extracellular region (Agt)
extracellular matrix organization (Agt)
Anatomy Link Frequency
plasma 4
Sympathetic 2
nucleus 2
Agt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 5 100.00 Very High Very High Very High
Inflammation 10 99.40 Very High Very High Very High
nMDA receptor 1 98.04 Very High Very High Very High
anesthesia 6 98.00 Very High Very High Very High
antagonist 3 97.92 Very High Very High Very High
Opioid 4 89.12 High High
opiate 2 85.40 High High
ketamine 2 83.08 Quite High
narcan 7 81.52 Quite High
Clonidine 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Insulin Resistance 9 99.96 Very High Very High Very High
Acid Base Imbalance 6 99.56 Very High Very High Very High
INFLAMMATION 13 99.40 Very High Very High Very High
Chronic Renal Failure 31 98.60 Very High Very High Very High
Hypertension 14 98.24 Very High Very High Very High
Ureteral Obstruction 3 96.92 Very High Very High Very High
Frailty 19 87.60 High High
Uremia 5 86.44 High High
Appetite Loss 3 85.88 High High
Cardiovascular Disease 1 81.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results are consistent with the interpretation that the drinking response to angiotensin II is dependent upon the integrity of neurons with postsynaptic N-methyl-D-aspartate receptors within the median preoptic nucleus.
Positive_regulation (dependent) of Positive_regulation (response) of angiotensin II in nucleus associated with nmda receptor
1) Confidence 0.50 Published 1991 Journal Brain Res. Section Abstract Doc Link 1933297 Disease Relevance 0 Pain Relevance 0.44
In situ hybridization and Western blot analysis demonstrated angiotensinogen mRNA and angiotensin converting enzyme (ACE) protein localized to PTs and upregulated in obstructed kidneys, respectively, confirming an increased expression of renal RAS in vivo.
Positive_regulation (demonstrated) of Positive_regulation (upregulated) of angiotensinogen mRNA
2) Confidence 0.45 Published 2000 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 10807582 Disease Relevance 0.27 Pain Relevance 0.10
Exposure to the low-salt diet increased plasma renin activity and elevated plasma levels of angiotensin I and angiotensin II in SHR by 81% and 68%, respectively, above values determined in SHR fed a normal salt diet.
Positive_regulation (increased) of Positive_regulation (elevated) of angiotensin II in plasma
3) Confidence 0.32 Published 2000 Journal Hypertension Section Abstract Doc Link 10988275 Disease Relevance 0.29 Pain Relevance 0.14
In children and adults with CKD, these complications include metabolic acidosis, insulin resistance, increased glucocorticoid production, high levels of angiotensin II (Ang II), and inflammation [5–8].
Positive_regulation (levels) of Positive_regulation (increased) of angiotensin II associated with chronic renal failure, inflammation, insulin resistance and acid base imbalance
4) Confidence 0.11 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC2259254 Disease Relevance 1.04 Pain Relevance 0.05
Sympathetic outflow may be enhanced by elevated Angiotensin II levels.
Spec (may) Positive_regulation (enhanced) of Positive_regulation (elevated) of Angiotensin II in Sympathetic
5) Confidence 0.10 Published 1999 Journal Neth J Med Section Abstract Doc Link 10431550 Disease Relevance 0.96 Pain Relevance 0.03
Subcutaneous injection of Angiotensin II (AII) induces a rapid increase in water intake in the chick.
Positive_regulation (induces) of Positive_regulation (injection) of Angiotensin II
6) Confidence 0.06 Published 1991 Journal Poult. Sci. Section Abstract Doc Link 1780271 Disease Relevance 0 Pain Relevance 0.36
The results showed that the patient group had lower levels of beta-endorphin and leucine enkephalin (P < 0.001), higher levels of arginine vasopressin, plasma renin activity and angiotensin II (P < 0.01, P < 0.05 and P < 0.05, respectively), and normal level of neurotensin, as compared with those in normal group.
Positive_regulation (had) of Positive_regulation (levels) of angiotensin II in plasma associated with enkephalin
7) Confidence 0.04 Published 1995 Journal Int. J. Cardiol. Section Abstract Doc Link 8586472 Disease Relevance 0.42 Pain Relevance 0.65

General Comments

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