INT159809

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Context Info
Confidence 0.78
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 19
Disease Relevance 3.67
Pain Relevance 2.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpv4) cilium (Trpv4) transmembrane transport (Trpv4)
Anatomy Link Frequency
F11 2
sensory neurons 1
smooth muscle 1
spines 1
endothelium 1
Trpv4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hyperalgesia 59 99.04 Very High Very High Very High
dorsal root ganglion 224 97.44 Very High Very High Very High
fibrosis 14 95.32 Very High Very High Very High
Neuropathic pain 56 94.64 High High
Kinase C 8 93.20 High High
TRP channel 19 89.52 High High
IPN 14 87.48 High High
agonist 88 84.96 Quite High
imagery 168 83.32 Quite High
pruritus 2 76.32 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 59 99.04 Very High Very High Very High
Adhesions 42 98.12 Very High Very High Very High
Ganglion Cysts 224 97.44 Very High Very High Very High
Cancer 42 96.28 Very High Very High Very High
Cystic Fibrosis 14 95.32 Very High Very High Very High
Overactive Bladder 2 94.80 High High
Neuropathic Pain 70 94.64 High High
Inflammatory Pain 14 87.48 High High
Increased Venous Pressure Under Development 28 86.92 High High
Stress 15 86.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
From several reports, the involvement of cytoskeleton can be correlated with the localization and function of TRPV4.
Localization (localization) of TRPV4
1) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.67 Pain Relevance 0.27
Co-localization of tubulin and TRPV4 was also observed in filopodial structures that were developed from growth cones, from neurite-like structures as well as from cell bodies.
Localization (localization) of TRPV4 in neurite
2) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.15 Pain Relevance 0.06
Immunohistochemistry staining showed that TRPV4 colocalized with MaxiK channels in endothelium of mesenteric resistance arteries and with CGRP in sensory neurons/nerve fibers.
Localization (colocalized) of TRPV4 in endothelium
3) Confidence 0.74 Published 2010 Journal J. Hypertens. Section Body Doc Link 19996988 Disease Relevance 0 Pain Relevance 0
Previously we have shown that the transient receptor potential vanilloid 4 (TRPV4) channel regulates urinary bladder function, and that TRPV4 is expressed in both smooth muscle and urothelial cell types within the bladder wall.(1) Urothelial cells have also been suggested to express TRPV1 channels.(2) Therefore, we enzymatically isolated guinea-pig urothelial cells in an attempt to record TRPV4 and TRPV1-mediated currents.
Localization (record) of TRPV4 in urothelial cell associated with overactive bladder
4) Confidence 0.73 Published 2009 Journal Channels (Austin) Section Abstract Doc Link 19411839 Disease Relevance 0.09 Pain Relevance 0.21
Interestingly, a recent study shows that disruption of the actin cytoskeleton increases the intracellular mobility of TRPV4-GFP and results in loss of co-localization of TRPV4 with actin [68].
Localization (localization) of TRPV4
5) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.15 Pain Relevance 0
in the MBP-TRPV4-Ct complex, both in presence and absence of Ca2+.
Localization (absence) of TRPV4
6) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.39 Pain Relevance 0.27
Interestingly, a recent study shows that disruption of the actin cytoskeleton increases the intracellular mobility of TRPV4-GFP and results in loss of co-localization of TRPV4 with actin [68].
Localization (localization) of TRPV4
7) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.15 Pain Relevance 0
The extent of microtubule stabilization by TRPV4-Ct is apparently very strong as TRPV4-Ct stabilizes microtubules are resistant against potent microtubule destabilizers such as Nocodazole and Ca2+.
Localization (stabilization) of TRPV4
8) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0 Pain Relevance 0
We observed that TRPV4 co-localized with actin-enriched structures, such as focal adhesion points, filopodial and lamellipodial structures.
Localization (localized) of TRPV4 associated with adhesions
9) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.15 Pain Relevance 0.03
These results fit well with the previously described subcellular localizations of TRPV4 in actin cytoskeleton-enriched structures like dendritic spines [65].
Localization (localizations) of TRPV4 in spines
10) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.10 Pain Relevance 0.03
We observed co-localization between TRPV4 and microtubules in fixed F11 cells all along neurite-like structures.
Localization (localization) of TRPV4 in F11
11) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.24 Pain Relevance 0.07
This kind of submembranous tubulin accumulation was not observed in non-transfected cells (Fig. 3f), implying that this effect is primarily due to the presence of TRPV4.


Localization (presence) of TRPV4
12) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.18 Pain Relevance 0.10
Next, we addressed if TRPV4 similarly co-localizes with microtubules.
Localization (localizes) of TRPV4
13) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.25 Pain Relevance 0.07
It is also important to note that the presence of GFP tag (240 amino acid) at the C-terminus of TRPV4 retains perfect co-localization of TRPV4-GFP with actin and microtubule cytoskeleton, indicating that the tubulin-binding region located with the TRPV4-Ct is most likely not present at the extreme C-terminal free end of the TRPV4.
Localization (localization) of TRPV4
14) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.08 Pain Relevance 0
TRPV4 localizes to actin- and microtubule-enriched regions in F11 cell
Localization (localizes) of TRPV4 in F11
15) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0 Pain Relevance 0.03
Using fluorescent labelled Phalloidin, we observed co-localization of TRPV4 with actin at various actin cytoskeleton enriched regions, such as the actin ribs of the cortical membranous regions, and at filopodial and lamellipodial structures (Fig.
Localization (localization) of TRPV4 in ribs
16) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.10 Pain Relevance 0.08
Our findings suggest an important role of this phosphorylation in TRPV4 sensitization and the development of hyperalgesia.
Localization (sensitization) of TRPV4 associated with hyperalgesia
17) Confidence 0.60 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20043876 Disease Relevance 0.27 Pain Relevance 0.58
Previously we have shown that the transient receptor potential vanilloid 4 (TRPV4) channel regulates urinary bladder function, and that TRPV4 is expressed in both smooth muscle and urothelial cell types within the bladder wall.(1) Urothelial cells have also been suggested to express TRPV1 channels.(2) Therefore, we enzymatically isolated guinea-pig urothelial cells in an attempt to record TRPV4 and TRPV1-mediated currents.
Localization (record) of TRPV4 in smooth muscle associated with overactive bladder
18) Confidence 0.25 Published 2009 Journal Channels (Austin) Section Abstract Doc Link 19411839 Disease Relevance 0.09 Pain Relevance 0.21
The temperature-sensitive transient receptor potential (TRP) channels, is also called thermo TRP, including TRPV1, TRPV2, TRPV3, TRPV4, TRPM8 and TRPA1, which are expressed in sensory neurons and non-neuronal cells (e.g.keratinocyte, mast cell) of the skin.
Localization (called) of TRPV4 in sensory neurons
19) Confidence 0.21 Published 2009 Journal Zhejiang Da Xue Xue Bao Yi Xue Ban Section Abstract Doc Link 19693981 Disease Relevance 0.61 Pain Relevance 0.45

General Comments

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