INT15982

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.65
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 25
Total Number 25
Disease Relevance 23.19
Pain Relevance 3.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NLRP3) signal transduction (NLRP3) cytoplasm (NLRP3)
Anatomy Link Frequency
joints 1
vertebral arteries 1
blood 1
plasma 1
arm 1
NLRP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 2 99.60 Very High Very High Very High
Morphine 1 98.10 Very High Very High Very High
cINOD 8 97.68 Very High Very High Very High
tetrodotoxin 1 97.20 Very High Very High Very High
depression 2 96.52 Very High Very High Very High
Inflammation 195 96.12 Very High Very High Very High
Neurotransmitter 3 96.12 Very High Very High Very High
antagonist 49 93.72 High High
Action potential 5 91.36 High High
Catecholamine 6 90.24 High High
Disease Link Frequency Relevance Heat
Syndrome 418 100.00 Very High Very High Very High
Fever 61 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 15 100.00 Very High Very High Very High
Tumor Necrosis Factor Receptor-associated Periodic Syndrome 14 100.00 Very High Very High Very High
Crystal Associated Disease 24 99.84 Very High Very High Very High
Familial Mediterranean Fever 62 99.46 Very High Very High Very High
Infection 101 99.26 Very High Very High Very High
Acne 6 98.08 Very High Very High Very High
Apoptosis 25 97.96 Very High Very High Very High
INFLAMMATION 214 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
upon UV-B irradiation via the activation of Nalp3-inflammasome [30] as an alternative response to immunosuppression [31].
Positive_regulation (activation) of Nalp3
1) Confidence 0.65 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0.41 Pain Relevance 0.09
10 The mutated cryopyrin protein probably increases the rate of the inflammasome assembly independently of the usual stimuli needed in wild type protein.10,11 Thus the result is a gain of function mutation.
Positive_regulation (increases) of cryopyrin
2) Confidence 0.50 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880341 Disease Relevance 1.52 Pain Relevance 0.30
These studies help to explain the deleterious actions of nonsteroidal anti-inflammatory drugs on glomerular filtration in clinical conditions associated with a decreased effective blood volume and, therefore, activation of AII and other neurohormonal constrictors.
Positive_regulation (activation) of AII in blood associated with inflammation and cinod
3) Confidence 0.46 Published 1986 Journal Am. J. Med. Section Abstract Doc Link 3092664 Disease Relevance 0.17 Pain Relevance 0.17
The genes responsible for all these autoinflammatory HPFS have been identified, and include MEFV (encoding pyrin) responsible for FMF, TNFRSF1A for TRAPS, mevalonate kinase for HIDS, CIAS1/NLRP3 for CAPS, and the PSTPIP1 gene responsible for PAPA syndrome.
Positive_regulation (include) of NLRP3 associated with syndrome, tumor necrosis factor receptor-associated periodic syndrome, acne, familial mediterranean fever and fever
4) Confidence 0.45 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2948378 Disease Relevance 3.65 Pain Relevance 0.24
At initiation of the attack, plasma ACTH, AVP, norepinephrine and prostaglandin E2 were markedly elevated, whereas dopamine was undetectable.
Positive_regulation (elevated) of AVP in plasma associated with dopamine
5) Confidence 0.45 Published 1988 Journal Acta Endocrinol. Section Abstract Doc Link 2837885 Disease Relevance 0.86 Pain Relevance 0.22
It has been suggested that this may be due to an increase in the transportation rate of apolipoprotein AI and AII (De Oliviera e Silva et al 2000) or to an ethanol-induced redistribution of cholesteryl ester transport proteins between HDL and VLDL (Hannuksela et al 1996).
Positive_regulation (increase) of AII associated with disorder of lipid metabolism
6) Confidence 0.45 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993980 Disease Relevance 0.92 Pain Relevance 0.05
In a better-studied system, cryopyrin or NLRP3, which also has the PYD domain, is activated to assemble the inflammasome [33], a multi-protein structure that ultimately results in activation of pro-caspase-1 that, in turn, processes pro-IL-1?
Positive_regulation (activated) of cryopyrin
7) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 1.41 Pain Relevance 0.34
In a better-studied system, cryopyrin or NLRP3, which also has the PYD domain, is activated to assemble the inflammasome [33], a multi-protein structure that ultimately results in activation of pro-caspase-1 that, in turn, processes pro-IL-1?
Positive_regulation (activated) of NLRP3
8) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 1.40 Pain Relevance 0.34
Subcutaneous injection of Angiotensin II (AII) induces a rapid increase in water intake in the chick.
Positive_regulation (injection) of AII
9) Confidence 0.44 Published 1991 Journal Poult. Sci. Section Abstract Doc Link 1780271 Disease Relevance 0 Pain Relevance 0.36
The three autosomal-dominant syndromes that constitute CAPS are caused by single base mutations on the NLRP3 gene located on the long arm of chromosome 1 encoding the protein cryopyrin.1,3,8 Some mutations are specific to one of the syndromes and some overlap among all three syndromes (Table 1a).1,9 Often, especially in patients with NOMID, no mutations are found, thus it is clear that other factors influence the development and severity of CAPS.9
Positive_regulation (encoding) of cryopyrin in arm associated with cryopyrin-associated periodic syndromes and syndrome
10) Confidence 0.44 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880341 Disease Relevance 2.23 Pain Relevance 0.18
Mutations such as R260W, V198M, V262G can all, for example, result in MWS or FCAS (Dode et al 2002a), whilst on the other hand, Y570, F309SA and F523L are exclusively associated with severe forms of CINCA (Aksentijevich et al 2002).
Positive_regulation (result) of MWS associated with syndrome
11) Confidence 0.41 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727888 Disease Relevance 1.04 Pain Relevance 0
Mutations such as R260W, V198M, V262G can all, for example, result in MWS or FCAS (Dode et al 2002a), whilst on the other hand, Y570, F309SA and F523L are exclusively associated with severe forms of CINCA (Aksentijevich et al 2002).
Positive_regulation (result) of FCAS associated with syndrome
12) Confidence 0.41 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727888 Disease Relevance 1.04 Pain Relevance 0
The cells responded to factors known to stimulate ACTH release, including high K+, CRF, and angiotensin II (AII).
Positive_regulation (stimulate) of AII
13) Confidence 0.39 Published 1987 Journal Endocrinology Section Abstract Doc Link 3036472 Disease Relevance 0.31 Pain Relevance 0.14
Red traces show the stimulator commands used to activate FCU during an FES session for the same set of targets.
Positive_regulation (activate) of FCU
14) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691481 Disease Relevance 0.05 Pain Relevance 0.06
Gout, which is induced by the deposition of monosodium urate (MSU) in joints, is also associated with the direct activation of NALP3 by MSU [18].
Positive_regulation (activation) of NALP3 in joints associated with crystal associated disease
15) Confidence 0.30 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 1.01 Pain Relevance 0.20
NALP3 can also be activated by endogenous danger signals released from dying cells like uric acid [18].
Positive_regulation (activated) of NALP3
16) Confidence 0.30 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 0.94 Pain Relevance 0.17
Activated NLRP3 with ASC aggregates pro-caspase-1 molecules through the formation of a macromolecular inflammasome complex that facilitates subsequent pro-caspase-1 activation and pro-IL-1?
Positive_regulation (Activated) of NLRP3
17) Confidence 0.26 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0.10 Pain Relevance 0
At the bottom of the figure are shown the pulse widths of the stimuli derived from this neural discharge that were used to activate the wrist flexor FCU.
Positive_regulation (activate) of FCU in wrist
18) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691481 Disease Relevance 0 Pain Relevance 0
A constitutively active form of mutated NALP3/cryopyrin, which promotes IL-1?
Positive_regulation (mutated) of NALP3
19) Confidence 0.22 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 1.02 Pain Relevance 0.26
The genes responsible for all these autoinflammatory HPFS have been identified, and include MEFV (encoding pyrin) responsible for FMF, TNFRSF1A for TRAPS, mevalonate kinase for HIDS, CIAS1/NLRP3 for CAPS, and the PSTPIP1 gene responsible for PAPA syndrome.
Positive_regulation (include) of CIAS1 associated with syndrome, tumor necrosis factor receptor-associated periodic syndrome, acne, familial mediterranean fever and fever
20) Confidence 0.21 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2948378 Disease Relevance 3.65 Pain Relevance 0.24

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox