INT159835

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Context Info
Confidence 0.09
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.81
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Trim2) ligase activity (Trim2) cytoplasm (Trim2)
Trim2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antinociception 1 100.00 Very High Very High Very High
opioid receptor 2 99.68 Very High Very High Very High
antagonist 1 99.04 Very High Very High Very High
narcan 1 98.60 Very High Very High Very High
Antinociceptive 1 94.52 High High
Inflammation 4 91.32 High High
allodynia 1 90.80 High High
withdrawal 1 84.24 Quite High
Pain 7 82.16 Quite High
spastic colon 4 80.84 Quite High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

10 98.20 Very High Very High Very High
Nociception 3 97.08 Very High Very High Very High
Colitis 5 92.32 High High
INFLAMMATION 2 91.32 High High
Neuropathic Pain 1 90.80 High High
Pain 3 82.16 Quite High
Dyspepsia 1 67.40 Quite High
Functional Bowel Disorder 1 63.16 Quite High
Enteropathy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NO2-Arg-Trim-induced antinociception was reversed by the opioid receptor antagonist naloxone and by the NO synthase-cGMP pathway inhibitor methylene blue, while L-NAME had no effect.The antinociceptive effect of NO2-Arg-Trim was maintained in a rodent model of post-inflammatory allodynia.
Negative_regulation (reversed) of NO2-Arg-Trim-induced associated with antinociception, allodynia, inflammation, antagonist, narcan, opioid receptor and antinociceptive
1) Confidence 0.09 Published 2009 Journal Pharmacol. Res. Section Abstract Doc Link 19416632 Disease Relevance 1.09 Pain Relevance 1.14

General Comments

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