INT15984

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Context Info
Confidence 0.32
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 1.33
Pain Relevance 3.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Avp, Oxt) extracellular region (Avp, Oxt) response to stress (Avp, Oxt)
signal transduction (Avp) cytoplasm (Oxt) signal transducer activity (Avp)
Anatomy Link Frequency
plasma 1
mammary gland 1
pituitary 1
uterine 1
nucleus 1
Avp (Rattus norvegicus)
Oxt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dynorphin 6 100.00 Very High Very High Very High
opiate 3 99.98 Very High Very High Very High
antagonist 63 99.96 Very High Very High Very High
Morphine 25 99.52 Very High Very High Very High
tolerance 8 96.96 Very High Very High Very High
Opioid 2 96.28 Very High Very High Very High
Dismenorea 5 93.68 High High
agonist 27 84.24 Quite High
depression 3 82.64 Quite High
Hippocampus 4 71.64 Quite High
Disease Link Frequency Relevance Heat
Hyperphagia 6 96.52 Very High Very High Very High
Dysmenorrhea 4 93.68 High High
Increased Venous Pressure Under Development 2 93.68 High High
Depression 3 82.64 Quite High
Stress 12 75.32 Quite High
Reprotox - General 1 1 72.64 Quite High
Cv Unclassified Under Development 1 69.84 Quite High
Anxiety Disorder 8 63.32 Quite High
Pre-term Labor 4 48.16 Quite Low
Targeted Disruption 10 46.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Demonstration of vasopressin receptors by stimulation of inositol phosphate formation, and oxytocin receptors by binding of a specific 125I-labeled oxytocin antagonist, d(CH2)5(1)[Tyr(Me)2, Thr4,Tyr-NH2(9)]OVT.
vasopressin Binding (binding) of oxytocin associated with antagonist
1) Confidence 0.32 Published 1989 Journal Biochem. Cell Biol. Section Title Doc Link 2546575 Disease Relevance 0 Pain Relevance 0.20
Our results suggest that the stimulation of IP formation in rat mammary gland by oxytocin occurs through occupancy of AVP, and not oxytocin, receptor sites.
AVP Binding (occupancy) of oxytocin in mammary gland
2) Confidence 0.26 Published 1989 Journal Biochem. Cell Biol. Section Abstract Doc Link 2546575 Disease Relevance 0.09 Pain Relevance 0.36
These results are discussed in light of complex opiate-oxytocin/vasopressin interactions in the regulation of food intake.
vasopressin Binding (interactions) of oxytocin associated with opiate
3) Confidence 0.21 Published 1991 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1780342 Disease Relevance 0.19 Pain Relevance 0.63
These results are discussed in light of complex opiate-oxytocin/vasopressin interactions in the regulation of food intake.
vasopressin Binding (interactions) of oxytocin associated with opiate
4) Confidence 0.21 Published 1991 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1780342 Disease Relevance 0.19 Pain Relevance 0.63
Arginine vasopressin binds to both oxytocin and V1a receptors in the uterus, but the activation of V1a receptors appears not to be a mechanism involved in the uterine-stimulating action of vasopressin.
vasopressin Binding (binds) of oxytocin in uterine
5) Confidence 0.20 Published 1996 Journal Am. J. Obstet. Gynecol. Section Body Doc Link 8942510 Disease Relevance 0 Pain Relevance 0
The very potent opioid peptide, dynorphin, has recently been shown by radioimmunoassay and immunocytochemical techniques to be selectively concentrated in the pars nervosa of pituitary, suggesting a possible association of dynorphin with the neurohypophyseal hormones, vasopressin and oxytocin.
vasopressin Binding (association) of oxytocin in pituitary associated with dynorphin and opioid
6) Confidence 0.20 Published 1980 Journal Neurosci. Lett. Section Abstract Doc Link 6133255 Disease Relevance 0 Pain Relevance 0.32
The effects of acute and chronic morphine administration and the interaction with oxytocin and vasopressin on food intake response were investigated at various intervals during a 24-h schedule in rats.
vasopressin Binding (interaction) of oxytocin associated with morphine
7) Confidence 0.18 Published 1991 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1780342 Disease Relevance 0 Pain Relevance 0.34
Thus, vasopressin was 57-fold more potent than oxytocin.
vasopressin Binding (potent) of oxytocin
8) Confidence 0.12 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10440088 Disease Relevance 0.30 Pain Relevance 0.31
The effects of intra-hypothalamic microinjections of morphine (MOR) into the ventromedial (VMH) and lateral (LH) nucleus and its interactions with oxytocin (OXY) and vasopressin (AVP) were evaluated during food intake FI) in rats.
vasopressin Binding (interactions) of oxytocin in nucleus associated with morphine
9) Confidence 0.09 Published 1995 Journal Brain Res. Section Abstract Doc Link 7496813 Disease Relevance 0 Pain Relevance 0.64
When incubated with purified plasma membranes from rat or human myometrial tissue, OPC-21268 inhibited the specific receptor binding of tritiated oxytocin and vasopressin in a dose-dependent and reversible way.
vasopressin Binding (binding) of oxytocin in plasma
10) Confidence 0.05 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8566118 Disease Relevance 0.09 Pain Relevance 0.14
In 1986, Kai-Kai et al. identified immunoreactivity for vasopressin and oxytocin in neurones of the rat DRG [66].
vasopressin Binding (immunoreactivity) of oxytocin in DRG
11) Confidence 0.03 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2972642 Disease Relevance 0.47 Pain Relevance 0.08

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