INT159856

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Context Info
Confidence 0.67
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.94
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (RHO) plasma membrane (RHO) signal transducer activity (RHO)
Anatomy Link Frequency
neural 1
olfactory 1
RHO (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 1 98.16 Very High Very High Very High
cva 7 95.76 Very High Very High Very High
cINOD 1 86.48 High High
Inflammation 1 25.00 Low Low
Glutamate 24 5.00 Very Low Very Low Very Low
chemokine 11 5.00 Very Low Very Low Very Low
Glutamate receptor 6 5.00 Very Low Very Low Very Low
Neuropeptide 4 5.00 Very Low Very Low Very Low
Somatostatin 4 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acute Coronary Syndrome 1 99.56 Very High Very High Very High
Angina 1 98.16 Very High Very High Very High
Cv General 3 Under Development 7 95.76 Very High Very High Very High
INFLAMMATION 2 86.24 High High
Adhesions 52 76.08 Quite High
Stress 2 75.44 Quite High
Spasticity 1 75.00 Quite High
Disease 8 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Multiple System Atrophy 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with the activation of Rho GTPases, we found that pomalidomide enhanced F-actin formation, stabilized microtubules, and increased cell migration, all of which were blocked by selective inhibitors of ROCK1 and Rac1.
Positive_regulation (activation) of Rho
1) Confidence 0.67 Published 2009 Journal Blood Section Abstract Doc Link 19417207 Disease Relevance 0.16 Pain Relevance 0.09
Abnormal activation of Rho-family GTPases has been observed in cardiovascular disorders, but the function of genetic variability in Rho-family GTPases remains to be evaluated in cardiovascular disorders.
Positive_regulation (activation) of Rho
2) Confidence 0.67 Published 2010 Journal J. Hum. Genet. Section Abstract Doc Link 19911011 Disease Relevance 0.63 Pain Relevance 0.28
We recently showed that one member of the type I opsin family, the light-activated cation channel Channelrhodopsin-2 (ChR2), could mediate neural excitation in response to pulses of blue light (?
Positive_regulation (activated) of rhodopsin in neural
3) Confidence 0.49 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1808431 Disease Relevance 0 Pain Relevance 0
For example, a CLASS A (Rhodopsin) Amine family PSSM is generated by BLASTPGP using a set of known CLASS A Amine GPCRs as a query against a CLASS A amine database with two rounds of iteration (-j option).
Positive_regulation (generated) of Rhodopsin
4) Confidence 0.33 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2396169 Disease Relevance 0 Pain Relevance 0
This analysis shows the orthologous pairs of the chicken and human GPCRs, and we conclude that all the main groups of GPCRs, with the exception of Taste 2 and the olfactory subset of the Rhodopsin ?
Positive_regulation (subset) of Rhodopsin in olfactory
5) Confidence 0.24 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1472694 Disease Relevance 0.14 Pain Relevance 0

General Comments

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