INT159860

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Context Info
Confidence 0.05
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.90
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CDC42EP5) cytoskeleton (CDC42EP5) cytoplasm (CDC42EP5)
Anatomy Link Frequency
T cells 1
CDC42EP5 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 3 94.84 High High
metalloproteinase 58 50.00 Quite Low
Potency 5 29.44 Quite Low
rheumatoid arthritis 15 5.00 Very Low Very Low Very Low
Osteoarthritis 15 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 10 94.64 High High
Disease 90 94.52 High High
Stress 2 92.84 High High
Hypercalcemia 16 81.64 Quite High
Apoptosis 9 74.72 Quite High
Arthritis 16 5.00 Very Low Very Low Very Low
Osteoarthritis 16 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 15 5.00 Very Low Very Low Very Low
Cancer 10 5.00 Very Low Very Low Very Low
Calcification 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunomodulatory drugs reorganize cytoskeleton by modulating Rho GTPases.
Regulation (modulating) of GTPases
1) Confidence 0.05 Published 2009 Journal Blood Section Title Doc Link 19417207 Disease Relevance 0.16 Pain Relevance 0.09
Finally, we demonstrated that pomalidomide was able to regulate the activity of Rho GTPases and the formation of F-actin in primary human T cells as it did in monocytes and showed that the activation of RhoA was essential for pomalidomide-induced interleukin-2 expression in T cells.
Regulation (regulate) of GTPases in T cells
2) Confidence 0.02 Published 2009 Journal Blood Section Abstract Doc Link 19417207 Disease Relevance 0.16 Pain Relevance 0.07
Members of the Rab family of small GTPases such as Rab7 are master regulators of vesicular trafficking, maturation and fusion.
Regulation (regulators) of GTPases
3) Confidence 0.00 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.09 Pain Relevance 0
Both alendronate and tildronate can inhibit several protein tyrosine phosphatases [23-25] and can also affect small GTPases such as Rho and Rac, explaining some of the cytoskeletal effects.
Regulation (affect) of GTPases
4) Confidence 0.00 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154424 Disease Relevance 0.48 Pain Relevance 0

General Comments

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