INT159864

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Context Info
Confidence 0.73
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.33
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP3A5) oxidoreductase activity (CYP3A5) endoplasmic reticulum (CYP3A5)
Anatomy Link Frequency
liver 1
CYP3A5 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 1 99.58 Very High Very High Very High
opioid receptor 1 99.42 Very High Very High Very High
Oxycodone 4 98.94 Very High Very High Very High
Bile 1 86.48 High High
Bioavailability 3 59.72 Quite High
Paracetamol 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
fluoxetine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 5 78.56 Quite High
Renal Disease 1 75.92 Quite High
Short Bowel Syndrome 1 70.68 Quite High
Myeloid Leukemia 86 57.40 Quite High
Leukemia 14 50.00 Quite Low
Toxicity 13 45.92 Quite Low
Blast Crisis 19 33.80 Quite Low
Pressure And Volume Under Development 23 5.00 Very Low Very Low Very Low
Disease 18 5.00 Very Low Very Low Very Low
Heart Rate Under Development 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACKGROUND: Oxycodone is a mu-opioid receptor agonist that is metabolized mainly in the liver by cytochrome P450 3A and 2D6 enzymes.
Localization (metabolized) of cytochrome P450 in liver associated with oxycodone, agonist and opioid receptor
1) Confidence 0.73 Published 2009 Journal Anesthesiology Section Abstract Doc Link 19417618 Disease Relevance 0 Pain Relevance 0.45
Imatinib is metabolized mainly by CYP3A4 or CYP3A5 and can competitively inhibit the metabolism of drugs that are CYP3A4 or CYP3A5 substrates.
Localization (metabolized) of CYP3A5
2) Confidence 0.19 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503652 Disease Relevance 0.33 Pain Relevance 0.07

General Comments

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