INT159898

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Context Info
Confidence 0.74
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.33
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpm8) transmembrane transport (Trpm8)
Anatomy Link Frequency
sensory neurons 1
autonomic 1
Trpm8 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 30 99.52 Very High Very High Very High
trigeminal ganglion 22 98.08 Very High Very High Very High
dorsal root ganglion 24 97.80 Very High Very High Very High
TRP channel 13 93.76 High High
withdrawal 45 80.48 Quite High
qutenza 9 78.40 Quite High
Neuropathic pain 23 78.00 Quite High
allodynia 35 58.96 Quite High
Hyperalgesia 16 50.00 Quite Low
Eae 16 46.20 Quite Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 48 98.08 Very High Very High Very High
Nervous System Injury 29 83.32 Quite High
Hypersensitivity 76 82.72 Quite High
Leukemia 1 81.12 Quite High
Neuropathic Pain 77 78.40 Quite High
Injury 71 75.52 Quite High
Hyperalgesia 36 50.00 Quite Low
Pain 44 5.00 Very Low Very Low Very Low
Nociception 27 5.00 Very Low Very Low Very Low
INFLAMMATION 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lysophospholipids are produced by the activity of PLA2 and so PLA2 inhibition would not be expected to affect any TRPM8-mediated behavioural effects of LPC.
Localization (effects) of TRPM8-mediated
1) Confidence 0.74 Published 2010 Journal Mol Pain Section Body Doc Link PMC2822744 Disease Relevance 0.29 Pain Relevance 0.11
Intragastric administration of TRPV1, TRPV3, TRPM8, and TRPA1 agonists modulates autonomic thermoregulation in different manners in mice.
Localization (administration) of TRPM8 in autonomic associated with agonist
2) Confidence 0.70 Published 2009 Journal Biosci. Biotechnol. Biochem. Section Title Doc Link 19420725 Disease Relevance 0 Pain Relevance 0.42
Indeed, menthol has been demonstrated to evoke Ca2+ release from intracellular stores via a TRPM8-independent pathway [42], and to activate TRPA1 at lower concentrations [43], [44].
Localization (release) of TRPM8
3) Confidence 0.70 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 0.56 Pain Relevance 0.17
To detect TRPV1, TRPM8, and TRPA1 mRNA expression in sensory neurons, TG and DRG tissues from control rats and mice were isolated for RNA extraction followed by RT-PCR and gel electrophoresis.
Localization (detect) of TRPM8 in sensory neurons associated with dorsal root ganglion and trigeminal ganglion
4) Confidence 0.63 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 0.47 Pain Relevance 0.20

General Comments

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