INT159899

Context Info Confidence 0.75 First Reported 2005 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 9 Total Number 9 Disease Relevance 1.90 Pain Relevance 3.40

transport (Trpa1) transmembrane transport (Trpa1)

Anatomy Link Frequency sensory neurons 1 neuronal 1 nerve 1 hair cells 1 autonomic 1 Trpa1 (Mus musculus)

Pain Link Frequency Relevance Heat agonist 19 99.96 c fibre 34 99.92 trigeminal ganglion 22 98.72 dorsal root ganglion 32 98.44 nociceptor 147 98.16 Inflammatory mediators 2 96.56 TRP channel 33 94.20 Morphine 83 94.04 Mechanotransduction 9 93.52 Action potential 63 93.44

Disease Link Frequency Relevance Heat Ganglion Cysts 56 98.72 INFLAMMATION 50 96.56 Hyperalgesia 73 87.84 Leukemia 1 82.40 Nociception 32 78.56 Cancer 5 76.76 Injury 12 69.04 Pain 77 68.36 Radiodermatitis 2 63.36 Neuropathic Pain 78 59.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Recordings in skin nerve preparations from TRPA1 deficient mice and their wild type littermates revealed that in the absence of TRPA1, C fiber and A?

Neg (absence) Localization (absence) of TRPA1 in nerve associated with c fibre

1) Confidence 0.75 Published 2009 Journal Mol Pain Section Body Doc Link PMC2681449 Disease Relevance 0.18 Pain Relevance 0.54

For example, it is possible that normally, TRPA1 activation near the epidermal surface of the skin leads to the release of signaling molecules from non-neuronal skin cells that potentiate the A-mechanoreceptors.

Localization (release) of TRPA1 in neuronal

2) Confidence 0.75 Published 2009 Journal Mol Pain Section Body Doc Link PMC2681449 Disease Relevance 0.38 Pain Relevance 0.66

Intragastric administration of TRPV1, TRPV3, TRPM8, and TRPA1 agonists modulates autonomic thermoregulation in different manners in mice.

Localization (administration) of TRPA1 in autonomic associated with agonist

3) Confidence 0.73 Published 2009 Journal Biosci. Biotechnol. Biochem. Section Title Doc Link 19420725 Disease Relevance 0 Pain Relevance 0.42

Methods: The localization of TRPV1–4, TRPM5 and 8, and TRPA1 in the OE of normal and methimazole-treated CBA/J mice was investigated by immunohistochemistry.

Localization (localization) of TRPA1

4) Confidence 0.68 Published 2010 Journal Acta Oto-Laryngologica Section Abstract Doc Link PMC2981077 Disease Relevance 0 Pain Relevance 0.04

The following primer pairs were used: TRPA1 (Forward: 5'-GGAGACCCTGCTTCACAGAG-3', Reverse: 5'-AGTGGAGAGCGTCCTTCAGA-3'), HPRT (Hypoxanthine phosphoribosyl transferase) (Forward: 5'-GGCCAGACTTTGTTGGATTTG-3', Reverse: 5'-TGCGCTCATCTTAGGCTTTGT-3') In Situ Hybridization and Immunostaining

Localization (used) of TRPA1

5) Confidence 0.55 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.08 Pain Relevance 0

Furthermore, concentrations below the threshold of activation sensitized the CGRP release evoked by noxious heat and acrolein, activators of TRPV1 and TRPA1 receptors, respectively.

Localization (release) of TRPA1

6) Confidence 0.39 Published 2009 Journal Mol Pain Section Body Doc Link PMC2672059 Disease Relevance 0.30 Pain Relevance 0.93

Alternatively, mechanical damage could indirectly activate TRPA1 through release of reactive compounds or intracellular calcium (both of which can directly activate mammalian TRPA1) [11,12,31].

Localization (release) of TRPA1

7) Confidence 0.32 Published 2007 Journal Mol Pain Section Body Doc Link PMC2222610 Disease Relevance 0.50 Pain Relevance 0.62

To detect TRPV1, TRPM8, and TRPA1 mRNA expression in sensory neurons, TG and DRG tissues from control rats and mice were isolated for RNA extraction followed by RT-PCR and gel electrophoresis.

Localization (detect) of TRPA1 mRNA in sensory neurons associated with dorsal root ganglion and trigeminal ganglion

8) Confidence 0.31 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 0.47 Pain Relevance 0.20

These findings were based upon localization of mTRPA1 transcripts and protein in hair cells, deficits in hair cell function after inhibition of TRPA1 protein expression, and similar biophysical and pharmacological properties of heterologously expressed TRPA1 and the hair cell transduction channel.

Localization (localization) of mTRPA1 in hair cells

9) Confidence 0.02 Published 2005 Journal Mol Pain Section Body Doc Link PMC1087877 Disease Relevance 0 Pain Relevance 0

General Comments

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